Tags

Type your tag names separated by a space and hit enter

Phosphate in early chronic kidney disease: associations with clinical outcomes and a target to reduce cardiovascular risk.
Nephrology (Carlton). 2012 Jul; 17(5):433-44.N

Abstract

There is an intimate association between mineral and bone disorders in chronic kidney disease (CKD) and the extensive burden of cardiovascular disease (CVD) in this population. High phosphate levels in CKD have been associated with increased all-cause mortality and cardiovascular morbidity and mortality. Observational studies have also shown a consistent relationship between serum phosphate in the normal range and all-cause and cardiovascular mortality, left ventricular hypertrophy (LVH) and decline in renal function. Furthermore, fibroblast growth factor-23 (FGF-23), a phosphaturic hormone, increases very early in the course of CKD and is strongly associated with death and CVD, including LVH and vascular calcification. Few studies have addressed outcomes using interventions to reduce serum phosphate in a randomized controlled fashion; however, strategies to address cardiovascular risk in early CKD are imperative and phosphate is a potential therapeutic target. This review outlines the epidemiological and experimental evidence highlighting the relationship between excess phosphate and adverse outcomes, and discusses clinical studies required to address this problem.

Authors+Show Affiliations

The Royal Melbourne Hospital, Grattan Street, Parkville, Vic. 3052, Australia. nigel.toussaint@mh.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22574672

Citation

Toussaint, Nigel D., et al. "Phosphate in Early Chronic Kidney Disease: Associations With Clinical Outcomes and a Target to Reduce Cardiovascular Risk." Nephrology (Carlton, Vic.), vol. 17, no. 5, 2012, pp. 433-44.
Toussaint ND, Pedagogos E, Tan SJ, et al. Phosphate in early chronic kidney disease: associations with clinical outcomes and a target to reduce cardiovascular risk. Nephrology (Carlton). 2012;17(5):433-44.
Toussaint, N. D., Pedagogos, E., Tan, S. J., Badve, S. V., Hawley, C. M., Perkovic, V., & Elder, G. J. (2012). Phosphate in early chronic kidney disease: associations with clinical outcomes and a target to reduce cardiovascular risk. Nephrology (Carlton, Vic.), 17(5), 433-44. https://doi.org/10.1111/j.1440-1797.2012.01618.x
Toussaint ND, et al. Phosphate in Early Chronic Kidney Disease: Associations With Clinical Outcomes and a Target to Reduce Cardiovascular Risk. Nephrology (Carlton). 2012;17(5):433-44. PubMed PMID: 22574672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphate in early chronic kidney disease: associations with clinical outcomes and a target to reduce cardiovascular risk. AU - Toussaint,Nigel D, AU - Pedagogos,Eugenie, AU - Tan,Sven-Jean, AU - Badve,Sunil V, AU - Hawley,Carmel M, AU - Perkovic,Vlado, AU - Elder,Grahame J, PY - 2012/5/12/entrez PY - 2012/5/12/pubmed PY - 2012/10/30/medline SP - 433 EP - 44 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 17 IS - 5 N2 - There is an intimate association between mineral and bone disorders in chronic kidney disease (CKD) and the extensive burden of cardiovascular disease (CVD) in this population. High phosphate levels in CKD have been associated with increased all-cause mortality and cardiovascular morbidity and mortality. Observational studies have also shown a consistent relationship between serum phosphate in the normal range and all-cause and cardiovascular mortality, left ventricular hypertrophy (LVH) and decline in renal function. Furthermore, fibroblast growth factor-23 (FGF-23), a phosphaturic hormone, increases very early in the course of CKD and is strongly associated with death and CVD, including LVH and vascular calcification. Few studies have addressed outcomes using interventions to reduce serum phosphate in a randomized controlled fashion; however, strategies to address cardiovascular risk in early CKD are imperative and phosphate is a potential therapeutic target. This review outlines the epidemiological and experimental evidence highlighting the relationship between excess phosphate and adverse outcomes, and discusses clinical studies required to address this problem. SN - 1440-1797 UR - https://www.unboundmedicine.com/medline/citation/22574672/Phosphate_in_early_chronic_kidney_disease:_associations_with_clinical_outcomes_and_a_target_to_reduce_cardiovascular_risk_ L2 - https://doi.org/10.1111/j.1440-1797.2012.01618.x DB - PRIME DP - Unbound Medicine ER -