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Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men.
Nutr Res. 2012 Apr; 32(4):241-50.NR

Abstract

Nutrients such as omega-3 oils and phosphatidylserine have been considered to exert stress-buffering effects. In this randomized, double-blind, placebo-controlled trial, we investigated effects of omega-3 phosphatidylserine (PS) on perceived chronic stress, assessed by the Trier Inventory for Chronic Stress (Schulz P, Schlotz W, Becker P. TICS: Trierer Inventar zum chronischen Stress. Göttingen, Germany: Hogrefe, 2004.), and on psychobiological stress responses to an acute laboratory stress protocol, the Trier Social Stress Test (Neuropsychobiology.1993;28:76-81), at baseline and after the treatment period. We hypothesized that omega-3 PS supplementation lowers chronic and acute stress. Sixty healthy nonsmoking men aged 30 to 60 years either received omega-3 PS or a matching placebo for 12 weeks. Results revealed no significant main effect of omega-3 PS supplementation on stress measures. However, by accounting for chronic stress level of study participants, stress-reducing effects of omega-3 PS were found exclusively for high chronically stressed subjects. As expected, these individuals also showed a blunted cortisol response to the Trier Social Stress Test. Treatment with omega-3 PS seemed to restore the cortisol response in this particular subgroup of low responders. These results are in line with previous findings. We conclude that subgroups characterized by high chronic stress and/or a dysfunctional response of the hypothalamus-pituitary-adrenal axis may profit from omega-3 PS supplementation.

Authors+Show Affiliations

Diagnostic Assessment and Clinical Research Organization-Daacro, Science Park Trier, Max-Planck-Str. 22, D-54296 Trier, Germany. hellhammer@daacro.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22575036

Citation

Hellhammer, Juliane, et al. "Omega-3 Fatty Acids Administered in Phosphatidylserine Improved Certain Aspects of High Chronic Stress in Men." Nutrition Research (New York, N.Y.), vol. 32, no. 4, 2012, pp. 241-50.
Hellhammer J, Hero T, Franz N, et al. Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men. Nutr Res. 2012;32(4):241-50.
Hellhammer, J., Hero, T., Franz, N., Contreras, C., & Schubert, M. (2012). Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men. Nutrition Research (New York, N.Y.), 32(4), 241-50. https://doi.org/10.1016/j.nutres.2012.03.003
Hellhammer J, et al. Omega-3 Fatty Acids Administered in Phosphatidylserine Improved Certain Aspects of High Chronic Stress in Men. Nutr Res. 2012;32(4):241-50. PubMed PMID: 22575036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men. AU - Hellhammer,Juliane, AU - Hero,Torsten, AU - Franz,Nadin, AU - Contreras,Carina, AU - Schubert,Melanie, Y1 - 2012/04/30/ PY - 2011/09/09/received PY - 2012/03/04/revised PY - 2012/03/08/accepted PY - 2012/5/12/entrez PY - 2012/5/12/pubmed PY - 2012/10/12/medline SP - 241 EP - 50 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 32 IS - 4 N2 - Nutrients such as omega-3 oils and phosphatidylserine have been considered to exert stress-buffering effects. In this randomized, double-blind, placebo-controlled trial, we investigated effects of omega-3 phosphatidylserine (PS) on perceived chronic stress, assessed by the Trier Inventory for Chronic Stress (Schulz P, Schlotz W, Becker P. TICS: Trierer Inventar zum chronischen Stress. Göttingen, Germany: Hogrefe, 2004.), and on psychobiological stress responses to an acute laboratory stress protocol, the Trier Social Stress Test (Neuropsychobiology.1993;28:76-81), at baseline and after the treatment period. We hypothesized that omega-3 PS supplementation lowers chronic and acute stress. Sixty healthy nonsmoking men aged 30 to 60 years either received omega-3 PS or a matching placebo for 12 weeks. Results revealed no significant main effect of omega-3 PS supplementation on stress measures. However, by accounting for chronic stress level of study participants, stress-reducing effects of omega-3 PS were found exclusively for high chronically stressed subjects. As expected, these individuals also showed a blunted cortisol response to the Trier Social Stress Test. Treatment with omega-3 PS seemed to restore the cortisol response in this particular subgroup of low responders. These results are in line with previous findings. We conclude that subgroups characterized by high chronic stress and/or a dysfunctional response of the hypothalamus-pituitary-adrenal axis may profit from omega-3 PS supplementation. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/22575036/Omega_3_fatty_acids_administered_in_phosphatidylserine_improved_certain_aspects_of_high_chronic_stress_in_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(12)00046-2 DB - PRIME DP - Unbound Medicine ER -