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Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients.
Asian Pac J Trop Med. 2012 Jun; 5(6):469-71.AP

Abstract

OBJECTIVE

To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin (HbA(1c)).

METHODS

Samples were collected from 128 type 2 diabetic patients (aged 19-90 years; male 72, female 56). The sera were analyzed for HbA(1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to the HbA(1c) level, the patients were divided into three groups, group A (HbA(1c) <7%, n=31), group B (7%≤HbA(1c)≤10%, n=48), and group C (HbA(1c) >10%, n=49). The correlation of HbA(1c) with lipid ratios & individual lipid indexes were analyzed.

RESULTS

With the increased level of HbA(1c), LDL-C had a significantly increasing trend (P<0.05); whereas TC went up with the increased HbA(1c), without any significant differences between three groups. There was no significant correlation between HbA(1c) and TG or HDL-C. With the increased level of HbA(1c), TC/HDL-C, LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid.

CONCLUSIONS

LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.

Links

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Authors+Show Affiliations

Yan Z
Department of Endocrine and Metabolism, Sichuan University Westchina Hospital, Chengdu, Sichuan, China.
Liu Y
No affiliation info available
Huang H
No affiliation info available

MeSH

AdultAgedAged, 80 and overAnalysis of VarianceCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 2FemaleGlucose IntoleranceGlycated Hemoglobin AHumansMaleMiddle AgedTriglycerides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22575980

Citation

Yan, Zhe, et al. "Association of Glycosylated Hemoglobin Level With Lipid Ratio and Individual Lipids in Type 2 Diabetic Patients." Asian Pacific Journal of Tropical Medicine, vol. 5, no. 6, 2012, pp. 469-71.
Yan Z, Liu Y, Huang H. Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients. Asian Pac J Trop Med. 2012;5(6):469-71.
Yan, Z., Liu, Y., & Huang, H. (2012). Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients. Asian Pacific Journal of Tropical Medicine, 5(6), 469-71. https://doi.org/10.1016/S1995-7645(12)60080-7
Yan Z, Liu Y, Huang H. Association of Glycosylated Hemoglobin Level With Lipid Ratio and Individual Lipids in Type 2 Diabetic Patients. Asian Pac J Trop Med. 2012;5(6):469-71. PubMed PMID: 22575980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients. AU - Yan,Zhe, AU - Liu,Yang, AU - Huang,Hui, PY - 2012/02/15/received PY - 2012/03/15/revised PY - 2012/04/15/accepted PY - 2012/5/12/entrez PY - 2012/5/12/pubmed PY - 2012/7/17/medline SP - 469 EP - 71 JF - Asian Pacific journal of tropical medicine JO - Asian Pac J Trop Med VL - 5 IS - 6 N2 - OBJECTIVE: To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin (HbA(1c)). METHODS: Samples were collected from 128 type 2 diabetic patients (aged 19-90 years; male 72, female 56). The sera were analyzed for HbA(1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to the HbA(1c) level, the patients were divided into three groups, group A (HbA(1c) <7%, n=31), group B (7%≤HbA(1c)≤10%, n=48), and group C (HbA(1c) >10%, n=49). The correlation of HbA(1c) with lipid ratios & individual lipid indexes were analyzed. RESULTS: With the increased level of HbA(1c), LDL-C had a significantly increasing trend (P<0.05); whereas TC went up with the increased HbA(1c), without any significant differences between three groups. There was no significant correlation between HbA(1c) and TG or HDL-C. With the increased level of HbA(1c), TC/HDL-C, LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. CONCLUSIONS: LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients. SN - 2352-4146 UR - https://www.unboundmedicine.com/medline/citation/22575980/Association_of_glycosylated_hemoglobin_level_with_lipid_ratio_and_individual_lipids_in_type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1995-7645(12)60080-7 DB - PRIME DP - Unbound Medicine ER -