Tags

Type your tag names separated by a space and hit enter

Inflammation-based prognostic system predicts postoperative survival of colorectal cancer patients with a normal preoperative serum level of carcinoembryonic antigen.
Ann Surg Oncol. 2012 Oct; 19(11):3422-31.AS

Abstract

BACKGROUND

Although carcinoembryonic antigen (CEA) is a valuable indicator for estimating the progression of colorectal cancer (CRC), some patients with advanced CRC show no elevation of the CEA level. On the other hand, inflammation-based prognosis, assessed by the Glasgow Prognostic Score (GPS), has been established as one of the important prognostic factors of survival after surgery for several types of cancer. We estimated the postoperative survival of CRC patients with a normal preoperative serum level of CEA on the basis of the GPS.

METHODS

Among 491 patients who had undergone elective CRC surgery, 271 with a normal preoperative serum CEA level (≤5.0 ng/ml) were enrolled. Uni- and multivariate analyses were performed to evaluate the relationship to overall survival. Kaplan-Meier analysis and log rank test were used to compare the survival curves between patients with GPS 0 (group A), and 1 or 2 (group B).

RESULTS

Univariate analyses using clinical characteristics revealed that lymphatic invasion, lymph node metastasis, platelet count, the serum levels of CEA and C-reactive protein, tumor, node, metastasis staging system (stage 0, I, II/III, IV), and the GPS (0/1, 2) were associated with overall survival. Among these characteristics, multivariate analysis demonstrated that the GPS and platelet count were associated with overall survival. Kaplan-Meier analysis and log rank test demonstrated a significant difference in overall survival between groups A and B (P < 0.001).

CONCLUSIONS

Even if CRC patients have a normal preoperative serum level of CEA before surgery, the GPS is able to predict their postoperative survival.

Authors+Show Affiliations

Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan. mm-ishizuka@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22576063

Citation

Ishizuka, Mitsuru, et al. "Inflammation-based Prognostic System Predicts Postoperative Survival of Colorectal Cancer Patients With a Normal Preoperative Serum Level of Carcinoembryonic Antigen." Annals of Surgical Oncology, vol. 19, no. 11, 2012, pp. 3422-31.
Ishizuka M, Nagata H, Takagi K, et al. Inflammation-based prognostic system predicts postoperative survival of colorectal cancer patients with a normal preoperative serum level of carcinoembryonic antigen. Ann Surg Oncol. 2012;19(11):3422-31.
Ishizuka, M., Nagata, H., Takagi, K., Iwasaki, Y., & Kubota, K. (2012). Inflammation-based prognostic system predicts postoperative survival of colorectal cancer patients with a normal preoperative serum level of carcinoembryonic antigen. Annals of Surgical Oncology, 19(11), 3422-31. https://doi.org/10.1245/s10434-012-2384-5
Ishizuka M, et al. Inflammation-based Prognostic System Predicts Postoperative Survival of Colorectal Cancer Patients With a Normal Preoperative Serum Level of Carcinoembryonic Antigen. Ann Surg Oncol. 2012;19(11):3422-31. PubMed PMID: 22576063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammation-based prognostic system predicts postoperative survival of colorectal cancer patients with a normal preoperative serum level of carcinoembryonic antigen. AU - Ishizuka,Mitsuru, AU - Nagata,Hitoshi, AU - Takagi,Kazutoshi, AU - Iwasaki,Yoshimi, AU - Kubota,Keiichi, Y1 - 2012/05/11/ PY - 2011/12/01/received PY - 2012/5/12/entrez PY - 2012/5/12/pubmed PY - 2013/4/4/medline SP - 3422 EP - 31 JF - Annals of surgical oncology JO - Ann. Surg. Oncol. VL - 19 IS - 11 N2 - BACKGROUND: Although carcinoembryonic antigen (CEA) is a valuable indicator for estimating the progression of colorectal cancer (CRC), some patients with advanced CRC show no elevation of the CEA level. On the other hand, inflammation-based prognosis, assessed by the Glasgow Prognostic Score (GPS), has been established as one of the important prognostic factors of survival after surgery for several types of cancer. We estimated the postoperative survival of CRC patients with a normal preoperative serum level of CEA on the basis of the GPS. METHODS: Among 491 patients who had undergone elective CRC surgery, 271 with a normal preoperative serum CEA level (≤5.0 ng/ml) were enrolled. Uni- and multivariate analyses were performed to evaluate the relationship to overall survival. Kaplan-Meier analysis and log rank test were used to compare the survival curves between patients with GPS 0 (group A), and 1 or 2 (group B). RESULTS: Univariate analyses using clinical characteristics revealed that lymphatic invasion, lymph node metastasis, platelet count, the serum levels of CEA and C-reactive protein, tumor, node, metastasis staging system (stage 0, I, II/III, IV), and the GPS (0/1, 2) were associated with overall survival. Among these characteristics, multivariate analysis demonstrated that the GPS and platelet count were associated with overall survival. Kaplan-Meier analysis and log rank test demonstrated a significant difference in overall survival between groups A and B (P < 0.001). CONCLUSIONS: Even if CRC patients have a normal preoperative serum level of CEA before surgery, the GPS is able to predict their postoperative survival. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/22576063/Inflammation_based_prognostic_system_predicts_postoperative_survival_of_colorectal_cancer_patients_with_a_normal_preoperative_serum_level_of_carcinoembryonic_antigen_ L2 - https://dx.doi.org/10.1245/s10434-012-2384-5 DB - PRIME DP - Unbound Medicine ER -