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A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis.
ScientificWorldJournal. 2012; 2012:902676.S

Abstract

BACKGROUND

Glucosamine may be effective in treating and possibly slowing the progression of Osteoarthritis (OA). It is believed Glucosamine supplements may help to stop cartilage breakdown, build cartilage and decrease swelling.

OBJECTIVE

The objective of this study was glucosamine sulfate versus combination of glucosamine sulfate and Non-Steroidal anti-inflammatory drugs (NSAID) in mild to moderate knee osteoarthritis.

METHODS

Subjects were randomly recruited from Rheumatology outpatient department after a diagnosis of mild or moderate Osteoarthritis. Study tools like patient data collection form, Western Ontario McMaster Universities Arthritis index (WOMAC) of Osteoarthritis questionnaires and Visual Analog Scale (VAS) were used.

RESULTS

After 12 weeks, WOMAC total score the result showed that the significant mean difference between the group A and Group B treatment (P < 0.01), with a combination of GS and NSAIDs reducing VAS pain scores. Thus, it is found that Group B treatments over 4 and 12 weeks produced improved WOMAC and VAS grades.

CONCLUSIONS

Study results may suggest that the Glucosamine Sulfate has a carryover effect like Disease modifying agents. Long-term treatment of Glucosamine Sulfate may reduce the dependence of NSAIDs usage and delay the disease progression. Thereby we can reduce the NSAIDs side effects and improve the patient's quality of life.

Authors+Show Affiliations

Department of Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sicences, Guntur-522034, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22577354

Citation

Selvan, Tamil, et al. "A Clinical Study On Glucosamine Sulfate Versus Combination of Glucosamine Sulfate and NSAIDs in Mild to Moderate Knee Osteoarthritis." TheScientificWorldJournal, vol. 2012, 2012, p. 902676.
Selvan T, Rajiah K, Nainar MS, et al. A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis. ScientificWorldJournal. 2012;2012:902676.
Selvan, T., Rajiah, K., Nainar, M. S., & Mathew, E. M. (2012). A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis. TheScientificWorldJournal, 2012, 902676. https://doi.org/10.1100/2012/902676
Selvan T, et al. A Clinical Study On Glucosamine Sulfate Versus Combination of Glucosamine Sulfate and NSAIDs in Mild to Moderate Knee Osteoarthritis. ScientificWorldJournal. 2012;2012:902676. PubMed PMID: 22577354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis. AU - Selvan,Tamil, AU - Rajiah,Kingston, AU - Nainar,M Sundara-Moorthi, AU - Mathew,Elizabeth M, Y1 - 2012/04/01/ PY - 2011/10/14/received PY - 2011/12/04/accepted PY - 2012/5/12/entrez PY - 2012/5/12/pubmed PY - 2012/9/7/medline SP - 902676 EP - 902676 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 2012 N2 - BACKGROUND: Glucosamine may be effective in treating and possibly slowing the progression of Osteoarthritis (OA). It is believed Glucosamine supplements may help to stop cartilage breakdown, build cartilage and decrease swelling. OBJECTIVE: The objective of this study was glucosamine sulfate versus combination of glucosamine sulfate and Non-Steroidal anti-inflammatory drugs (NSAID) in mild to moderate knee osteoarthritis. METHODS: Subjects were randomly recruited from Rheumatology outpatient department after a diagnosis of mild or moderate Osteoarthritis. Study tools like patient data collection form, Western Ontario McMaster Universities Arthritis index (WOMAC) of Osteoarthritis questionnaires and Visual Analog Scale (VAS) were used. RESULTS: After 12 weeks, WOMAC total score the result showed that the significant mean difference between the group A and Group B treatment (P < 0.01), with a combination of GS and NSAIDs reducing VAS pain scores. Thus, it is found that Group B treatments over 4 and 12 weeks produced improved WOMAC and VAS grades. CONCLUSIONS: Study results may suggest that the Glucosamine Sulfate has a carryover effect like Disease modifying agents. Long-term treatment of Glucosamine Sulfate may reduce the dependence of NSAIDs usage and delay the disease progression. Thereby we can reduce the NSAIDs side effects and improve the patient's quality of life. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/22577354/A_clinical_study_on_glucosamine_sulfate_versus_combination_of_glucosamine_sulfate_and_NSAIDs_in_mild_to_moderate_knee_osteoarthritis_ L2 - https://doi.org/10.1100/2012/902676 DB - PRIME DP - Unbound Medicine ER -