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The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study.
Ophthalmology. 2012 Aug; 119(8):1628-33.O

Abstract

OBJECTIVE

To examine the associations of cataract and cataract surgery with early and late age-related macular degeneration (AMD) over a 20-year interval.

DESIGN

Longitudinal population-based study of age-related eye diseases.

PARTICIPANTS

Beaver Dam Eye Study participants.

METHODS

Persons aged 43 to 86 years participated in the baseline examination in 1988-1990. Participants were followed up at 5-year intervals after the baseline examination. Examinations consisted of ocular examination with lens and fundus photography, medical history, measurements of blood pressure, height, and weight. Values of risk variables were updated, and incidences of early and late AMD were calculated for each 5-year interval. Odds ratios were computed using discrete linear logistic regression modeling with generalized estimating equation methods to account for correlation between the eyes and multiple intervals.

MAIN OUTCOME MEASURES

Age-related macular degeneration.

RESULTS

After adjusting for age and sex, neither cataract nor cataract surgery was associated with increased odds for developing early AMD. Further adjusting for high-risk gene alleles (CFH and ARMS2) and other possible risk factors did not materially affect the odds ratio (OR). However, cataract surgery was associated with incidence of late AMD (OR 1.93; 95% confidence interval [CI], 1.28-2.90). This OR was not materially altered by further adjusting for high-risk alleles (CFH Y402H, ARMS2) or other risk factors. The OR for late AMD was higher for cataract surgery performed 5 or more years prior compared with less than 5 years prior.

CONCLUSIONS

These data strongly support the past findings of an association of cataract surgery with late AMD independent of other risk factors, including high-risk genetic status, and suggest the importance of considering these findings when counseling patients regarding cataract surgery. These findings should provide further impetus for the search for measures to prevent or delay the development of age-related cataract.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. kleinb@epi.ophth.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22578823

Citation

Klein, Barbara E K., et al. "The Relationship of Cataract and Cataract Extraction to Age-related Macular Degeneration: the Beaver Dam Eye Study." Ophthalmology, vol. 119, no. 8, 2012, pp. 1628-33.
Klein BE, Howard KP, Lee KE, et al. The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology. 2012;119(8):1628-33.
Klein, B. E., Howard, K. P., Lee, K. E., Iyengar, S. K., Sivakumaran, T. A., & Klein, R. (2012). The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology, 119(8), 1628-33. https://doi.org/10.1016/j.ophtha.2012.01.050
Klein BE, et al. The Relationship of Cataract and Cataract Extraction to Age-related Macular Degeneration: the Beaver Dam Eye Study. Ophthalmology. 2012;119(8):1628-33. PubMed PMID: 22578823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study. AU - Klein,Barbara E K, AU - Howard,Kerri P, AU - Lee,Kristine E, AU - Iyengar,Sudha K, AU - Sivakumaran,Theru A, AU - Klein,Ronald, Y1 - 2012/05/11/ PY - 2011/09/15/received PY - 2012/01/13/revised PY - 2012/01/26/accepted PY - 2012/5/15/entrez PY - 2012/5/15/pubmed PY - 2012/10/26/medline SP - 1628 EP - 33 JF - Ophthalmology JO - Ophthalmology VL - 119 IS - 8 N2 - OBJECTIVE: To examine the associations of cataract and cataract surgery with early and late age-related macular degeneration (AMD) over a 20-year interval. DESIGN: Longitudinal population-based study of age-related eye diseases. PARTICIPANTS: Beaver Dam Eye Study participants. METHODS: Persons aged 43 to 86 years participated in the baseline examination in 1988-1990. Participants were followed up at 5-year intervals after the baseline examination. Examinations consisted of ocular examination with lens and fundus photography, medical history, measurements of blood pressure, height, and weight. Values of risk variables were updated, and incidences of early and late AMD were calculated for each 5-year interval. Odds ratios were computed using discrete linear logistic regression modeling with generalized estimating equation methods to account for correlation between the eyes and multiple intervals. MAIN OUTCOME MEASURES: Age-related macular degeneration. RESULTS: After adjusting for age and sex, neither cataract nor cataract surgery was associated with increased odds for developing early AMD. Further adjusting for high-risk gene alleles (CFH and ARMS2) and other possible risk factors did not materially affect the odds ratio (OR). However, cataract surgery was associated with incidence of late AMD (OR 1.93; 95% confidence interval [CI], 1.28-2.90). This OR was not materially altered by further adjusting for high-risk alleles (CFH Y402H, ARMS2) or other risk factors. The OR for late AMD was higher for cataract surgery performed 5 or more years prior compared with less than 5 years prior. CONCLUSIONS: These data strongly support the past findings of an association of cataract surgery with late AMD independent of other risk factors, including high-risk genetic status, and suggest the importance of considering these findings when counseling patients regarding cataract surgery. These findings should provide further impetus for the search for measures to prevent or delay the development of age-related cataract. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/22578823/The_relationship_of_cataract_and_cataract_extraction_to_age_related_macular_degeneration:_the_Beaver_Dam_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(12)00111-X DB - PRIME DP - Unbound Medicine ER -