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Normal fasting plasma glucose and risk of prediabetes and type 2 diabetes: the Isfahan Diabetes Prevention Study.
Rev Diabet Stud 2011; 8(4):490-8RD

Abstract

AIM

To determine the association of fasting plasma glucose (FPG) level within normal range and the risk of prediabetes and type 2 diabetes in an Iranian population.

METHODS

A total of 806 first-degree relatives (FDRs) of patients with type 2 diabetes who had FPG levels less than 5.6 mmol/l (100 mg/dl) in 2003 to 2005, and who did not have diabetes or impaired fasting glucose (IFG), were followed through 2010 for the occurrence of prediabetes or type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-hour oral glucose tolerance test (OGTT).

RESULTS

The incidence of type 2 diabetes, impaired glucose tolerance (IGT), and IFG was 9.6 (95% confidence interval (CI): 6.8-12.4), 28.7 (23.8-33.6), and 33.0 (27.7-38.2) per 1,000 person-years based on 4,489 person-years of follow-up, respectively. FPG was associated with the incidence of diabetes, IGT, and IFG. The multivariate-adjusted hazard ratios (95% CI) for diabetes, IGT, and IFG were 1.36 (1.01-1.84), 1.45 (1.10-1.91) and 1.31 (1.00-1.71), for the highest quintile of FPG compared with the lowest quintile, respectively.

CONCLUSIONS

An increase in FPG in the normal range is associated with an increase in the incidence of IGT, IFG, and type 2 diabetes. These results prove FPG in the normal range to be useful in identifying apparently healthy FDRs of patients with type 2 diabetes at risk of developing prediabetes and diabetes.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran. janghorbani@hlth.mui.ac.irNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22580730

Citation

Janghorbani, Mohsen, and Masoud Amini. "Normal Fasting Plasma Glucose and Risk of Prediabetes and Type 2 Diabetes: the Isfahan Diabetes Prevention Study." The Review of Diabetic Studies : RDS, vol. 8, no. 4, 2011, pp. 490-8.
Janghorbani M, Amini M. Normal fasting plasma glucose and risk of prediabetes and type 2 diabetes: the Isfahan Diabetes Prevention Study. Rev Diabet Stud. 2011;8(4):490-8.
Janghorbani, M., & Amini, M. (2011). Normal fasting plasma glucose and risk of prediabetes and type 2 diabetes: the Isfahan Diabetes Prevention Study. The Review of Diabetic Studies : RDS, 8(4), pp. 490-8. doi:10.1900/RDS.2011.8.490.
Janghorbani M, Amini M. Normal Fasting Plasma Glucose and Risk of Prediabetes and Type 2 Diabetes: the Isfahan Diabetes Prevention Study. Rev Diabet Stud. 2011;8(4):490-8. PubMed PMID: 22580730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal fasting plasma glucose and risk of prediabetes and type 2 diabetes: the Isfahan Diabetes Prevention Study. AU - Janghorbani,Mohsen, AU - Amini,Masoud, Y1 - 2012/02/10/ PY - 2012/5/15/entrez PY - 2011/1/1/pubmed PY - 2012/9/20/medline SP - 490 EP - 8 JF - The review of diabetic studies : RDS JO - Rev Diabet Stud VL - 8 IS - 4 N2 - AIM: To determine the association of fasting plasma glucose (FPG) level within normal range and the risk of prediabetes and type 2 diabetes in an Iranian population. METHODS: A total of 806 first-degree relatives (FDRs) of patients with type 2 diabetes who had FPG levels less than 5.6 mmol/l (100 mg/dl) in 2003 to 2005, and who did not have diabetes or impaired fasting glucose (IFG), were followed through 2010 for the occurrence of prediabetes or type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-hour oral glucose tolerance test (OGTT). RESULTS: The incidence of type 2 diabetes, impaired glucose tolerance (IGT), and IFG was 9.6 (95% confidence interval (CI): 6.8-12.4), 28.7 (23.8-33.6), and 33.0 (27.7-38.2) per 1,000 person-years based on 4,489 person-years of follow-up, respectively. FPG was associated with the incidence of diabetes, IGT, and IFG. The multivariate-adjusted hazard ratios (95% CI) for diabetes, IGT, and IFG were 1.36 (1.01-1.84), 1.45 (1.10-1.91) and 1.31 (1.00-1.71), for the highest quintile of FPG compared with the lowest quintile, respectively. CONCLUSIONS: An increase in FPG in the normal range is associated with an increase in the incidence of IGT, IFG, and type 2 diabetes. These results prove FPG in the normal range to be useful in identifying apparently healthy FDRs of patients with type 2 diabetes at risk of developing prediabetes and diabetes. SN - 1614-0575 UR - https://www.unboundmedicine.com/medline/citation/22580730/Normal_fasting_plasma_glucose_and_risk_of_prediabetes_and_type_2_diabetes:_the_Isfahan_Diabetes_Prevention_Study_ L2 - http://www.soc-bdr.org/content/e4/articlelookup?showfulltext=1&volume=8&firstpage=490 DB - PRIME DP - Unbound Medicine ER -