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Increased urinary type II collagen C-telopeptide levels in Tunisian patients with knee osteoarthritis.
Clin Lab 2012; 58(3-4):209-15CL

Abstract

Osteoarthritis is characterized by a progressive degeneration of articular cartilage and loss of joint function. Clinical assessment of osteoarthritis is hampered by the lack of accurate measures of disease and disease progression, especially during the early stage.

BACKGROUND

To investigate urinary C-telopeptide fragments of type II collagen (CTX-II) levels in knee osteoarthritis in the Tunisian population compared with controls and to assess the association between this biomarker and radiological signs.

METHODS

One hundred and twenty five female patients with knee osteoarthritis, aged 53.6 +/- 7.6 years with disease duration of 3.6 +/- 3.8 years and 57 female age-matched controls underwent Lyon Schuss X-ray exams. Two experienced readers independently measured the joint space width (JSW) and classified each knee for severity using the Kellgren/Lawrence scale. The urinary concentration of CTX-II was measured by a competitive ELISA.

RESULTS

The levels of urinary CTX-II were significantly higher in knee osteoarthritis patients compared with controls (323.98 vs 218.04 microg/mol creatinine). A weak and non significant association between the CTX-II level and JSW was found. The significant correlations were observed between age and CTX-II in both groups and between BMI and CTX-II only in controls.

CONCLUSIONS

Analysis of CTX-II in urine samples of Tunisian patients with knee osteoarthritis provided a sensitive method to detect increased degradation of collagen type II in patients with osteoarthritis.

Authors+Show Affiliations

Department of Biochemistry, Charles Nicolle Hospital, Tunis, Tunisia. kalaie79@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22582493

Citation

Kalai, E, et al. "Increased Urinary Type II Collagen C-telopeptide Levels in Tunisian Patients With Knee Osteoarthritis." Clinical Laboratory, vol. 58, no. 3-4, 2012, pp. 209-15.
Kalai E, Bahlous A, Charni N, et al. Increased urinary type II collagen C-telopeptide levels in Tunisian patients with knee osteoarthritis. Clin Lab. 2012;58(3-4):209-15.
Kalai, E., Bahlous, A., Charni, N., Bouzid, K., Sahli, H., Chelly, M., ... Sellami, S. (2012). Increased urinary type II collagen C-telopeptide levels in Tunisian patients with knee osteoarthritis. Clinical Laboratory, 58(3-4), pp. 209-15.
Kalai E, et al. Increased Urinary Type II Collagen C-telopeptide Levels in Tunisian Patients With Knee Osteoarthritis. Clin Lab. 2012;58(3-4):209-15. PubMed PMID: 22582493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased urinary type II collagen C-telopeptide levels in Tunisian patients with knee osteoarthritis. AU - Kalai,E, AU - Bahlous,A, AU - Charni,N, AU - Bouzid,K, AU - Sahli,H, AU - Chelly,M, AU - Meddeb,M, AU - Zouari,B, AU - Abdelmoula,J, AU - Sellami,S, PY - 2012/5/16/entrez PY - 2012/5/16/pubmed PY - 2012/6/19/medline SP - 209 EP - 15 JF - Clinical laboratory JO - Clin. Lab. VL - 58 IS - 3-4 N2 - UNLABELLED: Osteoarthritis is characterized by a progressive degeneration of articular cartilage and loss of joint function. Clinical assessment of osteoarthritis is hampered by the lack of accurate measures of disease and disease progression, especially during the early stage. BACKGROUND: To investigate urinary C-telopeptide fragments of type II collagen (CTX-II) levels in knee osteoarthritis in the Tunisian population compared with controls and to assess the association between this biomarker and radiological signs. METHODS: One hundred and twenty five female patients with knee osteoarthritis, aged 53.6 +/- 7.6 years with disease duration of 3.6 +/- 3.8 years and 57 female age-matched controls underwent Lyon Schuss X-ray exams. Two experienced readers independently measured the joint space width (JSW) and classified each knee for severity using the Kellgren/Lawrence scale. The urinary concentration of CTX-II was measured by a competitive ELISA. RESULTS: The levels of urinary CTX-II were significantly higher in knee osteoarthritis patients compared with controls (323.98 vs 218.04 microg/mol creatinine). A weak and non significant association between the CTX-II level and JSW was found. The significant correlations were observed between age and CTX-II in both groups and between BMI and CTX-II only in controls. CONCLUSIONS: Analysis of CTX-II in urine samples of Tunisian patients with knee osteoarthritis provided a sensitive method to detect increased degradation of collagen type II in patients with osteoarthritis. SN - 1433-6510 UR - https://www.unboundmedicine.com/medline/citation/22582493/Increased_urinary_type_II_collagen_C_telopeptide_levels_in_Tunisian_patients_with_knee_osteoarthritis_ DB - PRIME DP - Unbound Medicine ER -