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A clinical trial comparing a new NSAID (droxicam) and piroxicam in spinal osteoarthritis.
Int J Clin Pharmacol Ther Toxicol. 1990 Oct; 28(10):416-9.IJ

Abstract

This double-blind, parallel, controlled and randomized trial compares the clinical efficacy and tolerance of a new NSAID (pro-drug of piroxicam), droxicam, at the dose of 20 mg/day against that of piroxicam at the same dose. The comparison is drawn after the administration to 30 patients with spinal osteoarthritis during 8 weeks after a single-blind placebo-period run-in of 7 days. Results show that both drugs improve, with statistical significance, all parameters evaluated (pain intensity, morning stiffness, nocturnal pain, pain after getting up and after 30 min standing, difficulty in daily living, frequency of pain exacerbations and the ability to do several daily activities). No statistically significant differences were found between groups. Only one case in the droxicam group and two in the piroxicam group reported subjective complaints of mild intensity that did not require additional treatment or interruption of the study.

Authors+Show Affiliations

Laboratorios Dr. Esteve, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2258250

Citation

Bohl, D, et al. "A Clinical Trial Comparing a New NSAID (droxicam) and Piroxicam in Spinal Osteoarthritis." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 28, no. 10, 1990, pp. 416-9.
Bohl D, Gausmann H, Vorberg G, et al. A clinical trial comparing a new NSAID (droxicam) and piroxicam in spinal osteoarthritis. Int J Clin Pharmacol Ther Toxicol. 1990;28(10):416-9.
Bohl, D., Gausmann, H., Vorberg, G., Sánchez, J., García-Barbal, R., Sarti, J. F., & Harrison, F. J. (1990). A clinical trial comparing a new NSAID (droxicam) and piroxicam in spinal osteoarthritis. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 28(10), 416-9.
Bohl D, et al. A Clinical Trial Comparing a New NSAID (droxicam) and Piroxicam in Spinal Osteoarthritis. Int J Clin Pharmacol Ther Toxicol. 1990;28(10):416-9. PubMed PMID: 2258250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A clinical trial comparing a new NSAID (droxicam) and piroxicam in spinal osteoarthritis. AU - Bohl,D, AU - Gausmann,H, AU - Vorberg,G, AU - Sánchez,J, AU - García-Barbal,R, AU - Sarti,J F, AU - Harrison,F J, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 416 EP - 9 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 28 IS - 10 N2 - This double-blind, parallel, controlled and randomized trial compares the clinical efficacy and tolerance of a new NSAID (pro-drug of piroxicam), droxicam, at the dose of 20 mg/day against that of piroxicam at the same dose. The comparison is drawn after the administration to 30 patients with spinal osteoarthritis during 8 weeks after a single-blind placebo-period run-in of 7 days. Results show that both drugs improve, with statistical significance, all parameters evaluated (pain intensity, morning stiffness, nocturnal pain, pain after getting up and after 30 min standing, difficulty in daily living, frequency of pain exacerbations and the ability to do several daily activities). No statistically significant differences were found between groups. Only one case in the droxicam group and two in the piroxicam group reported subjective complaints of mild intensity that did not require additional treatment or interruption of the study. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/2258250/A_clinical_trial_comparing_a_new_NSAID__droxicam__and_piroxicam_in_spinal_osteoarthritis_ L2 - https://medlineplus.gov/osteoarthritis.html DB - PRIME DP - Unbound Medicine ER -