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Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities.
Nat Prod Res. 2013; 27(11):997-1001.NP

Abstract

The essential oils from the leaves of Annona pickelii and Annona salzmannii (Annonaceae) were obtained by hydrodistillation using a Clevenger apparatus, and analysed by GC-MS and GC-FID. A total of 21 compounds were identified in the essential oil of A. pickelii and 23 in that of A. salzmannii; sesquiterpenes predominated in both essential oils. Bicyclogermacrene (38.0%), (E)-caryophyllene (27.8%), α-copaene (6.9%) and α-humulene (4.0%) were the main components of A. pickelii, while δ-cadinene (22.6%), (E)-caryophyllene (21.4%), α-copaene (13.3%), bicyclogermacrene (11.3%) and germacrene D (6.9%) were the main components of A. salzmannii. The biological activities of the essential oils against Trypanosoma cruzi epimastigote forms and cytotoxicity against tumour cell lines (antitumour) were investigated. The essential oils showed potent trypanocidal and antitumour activities with values of IC50 lower than 100 µg mL(-1).

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Authors+Show Affiliations

Costa EV
Departamento de Química, Universidade Federal de Sergipe, 49100-000 São Cristóvão, SE, Brazil. emmanoelvc@gmail.com
Dutra LM
No affiliation info available
Salvador MJ
No affiliation info available
Ribeiro LH
No affiliation info available
Gadelha FR
No affiliation info available
de Carvalho JE
No affiliation info available

MeSH

AnnonaceaeAntineoplastic Agents, PhytogenicCell LineChromatography, GasHumansInhibitory Concentration 50Mass SpectrometryOils, VolatileTrypanocidal Agents

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22583044

Citation

Costa, Emmanoel Vilaça, et al. "Chemical Composition of the Essential Oils of Annona Pickelii and Annona Salzmannii (Annonaceae), and Their Antitumour and Trypanocidal Activities." Natural Product Research, vol. 27, no. 11, 2013, pp. 997-1001.
Costa EV, Dutra LM, Salvador MJ, et al. Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities. Nat Prod Res. 2013;27(11):997-1001.
Costa, E. V., Dutra, L. M., Salvador, M. J., Ribeiro, L. H., Gadelha, F. R., & de Carvalho, J. E. (2013). Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities. Natural Product Research, 27(11), 997-1001. https://doi.org/10.1080/14786419.2012.686913
Costa EV, et al. Chemical Composition of the Essential Oils of Annona Pickelii and Annona Salzmannii (Annonaceae), and Their Antitumour and Trypanocidal Activities. Nat Prod Res. 2013;27(11):997-1001. PubMed PMID: 22583044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities. AU - Costa,Emmanoel Vilaça, AU - Dutra,Lívia Macedo, AU - Salvador,Marcos José, AU - Ribeiro,Luis Henrique Gonzaga, AU - Gadelha,Fernanda Ramos, AU - de Carvalho,João Ernesto, Y1 - 2012/05/15/ PY - 2012/5/16/entrez PY - 2012/5/16/pubmed PY - 2014/1/16/medline SP - 997 EP - 1001 JF - Natural product research JO - Nat Prod Res VL - 27 IS - 11 N2 - The essential oils from the leaves of Annona pickelii and Annona salzmannii (Annonaceae) were obtained by hydrodistillation using a Clevenger apparatus, and analysed by GC-MS and GC-FID. A total of 21 compounds were identified in the essential oil of A. pickelii and 23 in that of A. salzmannii; sesquiterpenes predominated in both essential oils. Bicyclogermacrene (38.0%), (E)-caryophyllene (27.8%), α-copaene (6.9%) and α-humulene (4.0%) were the main components of A. pickelii, while δ-cadinene (22.6%), (E)-caryophyllene (21.4%), α-copaene (13.3%), bicyclogermacrene (11.3%) and germacrene D (6.9%) were the main components of A. salzmannii. The biological activities of the essential oils against Trypanosoma cruzi epimastigote forms and cytotoxicity against tumour cell lines (antitumour) were investigated. The essential oils showed potent trypanocidal and antitumour activities with values of IC50 lower than 100 µg mL(-1). SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/22583044/Chemical_composition_of_the_essential_oils_of_Annona_pickelii_and_Annona_salzmannii__Annonaceae__and_their_antitumour_and_trypanocidal_activities_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2012.686913 DB - PRIME DP - Unbound Medicine ER -