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[Efficacy and safety of low-dose matrix-type transdermal fentanyl applied for opioid initiation].
Gan To Kagaku Ryoho. 2012 May; 39(5):765-8.GT

Abstract

Minimum-size matrix-type transdermal fentanyl(TDF)(Durotep®MTPatch 2.1mg), with a dose equivalent to half of a minimum-size conventional-type TDF(Durotep Patch 2.5mg), was newly produced. Now, the use of minimum-size matrix-type TDF at the early stage of opioid initiation has become possible. For several reasons, we sometimes encounter clinical cases where clinicians are inclined to use the minimum-size matrix-type TDF first without prior use of other opioids. In order to evaluate the efficacy and safety of minimum-size matrix-type TDF, we analyzed 49 patients, retrospectively for whom minimum-size matrix-type TDF was initiated. We used the Wong-Baker faces pain rating scale to assess the effect of matrix-type TDF. The rate of effective and ineffective cases were 55% and 37%, respectively, and 8% of cases could not be evaluated. The frequency of side effects such as nausea, somnolence, sense of fatigue and constipation was 20%, 16%, 4% and 2%, respectively. However, respiration depression was not documented at all. The score of the palliative prognostic index was significantly higher in ineffective cases compared with effective cases. Patients who were judged ineffective tended to have poor prognoses. One of the reasons matrix-type TDF was thought to be ineffective in such patients was that a rapid increase of the dose according to dynamic changes of symptoms was difficult. These findings suggest that we can use a matrix-type TDF as opioid initiation relatively safely, but in cases with poor prognoses, we should use it under appropriate and sufficient rescue setting only when other opioids cannot be prescribed.

Authors+Show Affiliations

Palliative Care Team, Tottori Red Cross Hospital.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

22584328

Citation

Yamaguchi, Yumi, et al. "[Efficacy and Safety of Low-dose Matrix-type Transdermal Fentanyl Applied for Opioid Initiation]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 39, no. 5, 2012, pp. 765-8.
Yamaguchi Y, Kagawa Y, Yoneta E, et al. [Efficacy and safety of low-dose matrix-type transdermal fentanyl applied for opioid initiation]. Gan To Kagaku Ryoho. 2012;39(5):765-8.
Yamaguchi, Y., Kagawa, Y., Yoneta, E., & Kunimori, K. (2012). [Efficacy and safety of low-dose matrix-type transdermal fentanyl applied for opioid initiation]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 39(5), 765-8.
Yamaguchi Y, et al. [Efficacy and Safety of Low-dose Matrix-type Transdermal Fentanyl Applied for Opioid Initiation]. Gan To Kagaku Ryoho. 2012;39(5):765-8. PubMed PMID: 22584328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Efficacy and safety of low-dose matrix-type transdermal fentanyl applied for opioid initiation]. AU - Yamaguchi,Yumi, AU - Kagawa,Yoko, AU - Yoneta,Eiko, AU - Kunimori,Kimiaki, PY - 2012/5/16/entrez PY - 2012/5/16/pubmed PY - 2012/6/20/medline SP - 765 EP - 8 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 39 IS - 5 N2 - Minimum-size matrix-type transdermal fentanyl(TDF)(Durotep®MTPatch 2.1mg), with a dose equivalent to half of a minimum-size conventional-type TDF(Durotep Patch 2.5mg), was newly produced. Now, the use of minimum-size matrix-type TDF at the early stage of opioid initiation has become possible. For several reasons, we sometimes encounter clinical cases where clinicians are inclined to use the minimum-size matrix-type TDF first without prior use of other opioids. In order to evaluate the efficacy and safety of minimum-size matrix-type TDF, we analyzed 49 patients, retrospectively for whom minimum-size matrix-type TDF was initiated. We used the Wong-Baker faces pain rating scale to assess the effect of matrix-type TDF. The rate of effective and ineffective cases were 55% and 37%, respectively, and 8% of cases could not be evaluated. The frequency of side effects such as nausea, somnolence, sense of fatigue and constipation was 20%, 16%, 4% and 2%, respectively. However, respiration depression was not documented at all. The score of the palliative prognostic index was significantly higher in ineffective cases compared with effective cases. Patients who were judged ineffective tended to have poor prognoses. One of the reasons matrix-type TDF was thought to be ineffective in such patients was that a rapid increase of the dose according to dynamic changes of symptoms was difficult. These findings suggest that we can use a matrix-type TDF as opioid initiation relatively safely, but in cases with poor prognoses, we should use it under appropriate and sufficient rescue setting only when other opioids cannot be prescribed. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/22584328/[Efficacy_and_safety_of_low_dose_matrix_type_transdermal_fentanyl_applied_for_opioid_initiation]_ L2 - http://www.pieronline.jp/openurl?issn=0385-0684&volume=39&issue=5&spage=765 DB - PRIME DP - Unbound Medicine ER -