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Enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(II) complex.
Org Biomol Chem. 2012 Jun 28; 10(24):4731-8.OB

Abstract

The glucosamine derived glucoBOX-Cu(II) complex was found to be a unique catalytic system for enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-1-oxides. A large number of 3-alkylated indole derivatives were prepared using 5 mol% glucoBOX-Cu(II) complex in excellent yields with high enantioselectivity up to 99% ee.

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Publisher Full Text (DOI)

Authors+Show Affiliations

George J
Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Andhra Pradesh, India.
Reddy BV
No affiliation info available

MeSH

AlkylationCatalysisCopperIndolesLigandsMolecular StructureOxazolesOxidesPyridinesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22585295

Citation

George, Jimil, and B V Subba Reddy. "Enantioselective Friedel-Crafts Alkylation of Indoles With 2-enoylpyridine-N-oxides Catalyzed By glucoBOX-Cu(II) Complex." Organic & Biomolecular Chemistry, vol. 10, no. 24, 2012, pp. 4731-8.
George J, Reddy BV. Enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(II) complex. Org Biomol Chem. 2012;10(24):4731-8.
George, J., & Reddy, B. V. (2012). Enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(II) complex. Organic & Biomolecular Chemistry, 10(24), 4731-8. https://doi.org/10.1039/c2ob25315a
George J, Reddy BV. Enantioselective Friedel-Crafts Alkylation of Indoles With 2-enoylpyridine-N-oxides Catalyzed By glucoBOX-Cu(II) Complex. Org Biomol Chem. 2012 Jun 28;10(24):4731-8. PubMed PMID: 22585295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(II) complex. AU - George,Jimil, AU - Reddy,B V Subba, Y1 - 2012/05/15/ PY - 2012/5/16/entrez PY - 2012/5/16/pubmed PY - 2012/9/18/medline SP - 4731 EP - 8 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 10 IS - 24 N2 - The glucosamine derived glucoBOX-Cu(II) complex was found to be a unique catalytic system for enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-1-oxides. A large number of 3-alkylated indole derivatives were prepared using 5 mol% glucoBOX-Cu(II) complex in excellent yields with high enantioselectivity up to 99% ee. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/22585295/Enantioselective_Friedel_Crafts_alkylation_of_indoles_with_2_enoylpyridine_N_oxides_catalyzed_by_glucoBOX_Cu_II__complex_ L2 - https://doi.org/10.1039/c2ob25315a DB - PRIME DP - Unbound Medicine ER -