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Contaminant hepatotoxins as culprits for kava hepatotoxicity--fact or fiction?
Phytother Res. 2013 Mar; 27(3):472-4.PR

Abstract

The culprit of kava hepatotoxicity will continue to remain a mystery in humans, if the underlying reaction is of idiosyncratic, unpredictable, and dose-independent nature due potentially to some metabolic aberration in a few individuals emerging from kava use. In addition, kava hepatotoxicity is presently not reproducible experimentally in preclinical models, as demonstrated by studies showing whole kava extracts are not hepatotoxic. This led us to propose our 'working hypothesis' that contaminant hepatotoxins including moulds might have caused rare kava hepatotoxicity in humans. Further studies are now warranted to proof or disproof our working hypothesis, because kava hepatotoxicity possibly based on contaminant hepatotoxins could be a preventable disease. In the meantime, however, for minimizing toxicity risk in kava users, a pragmatic approach should focus on the medicinal use of an aqueous extract derived from peeled rhizomes and roots of a non-mouldy noble kava cultivar, limited to maximum 250-mg kavalactones daily for acute or intermittent use.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22585547

Citation

Teschke, Rolf, et al. "Contaminant Hepatotoxins as Culprits for Kava Hepatotoxicity--fact or Fiction?" Phytotherapy Research : PTR, vol. 27, no. 3, 2013, pp. 472-4.
Teschke R, Sarris J, Lebot V. Contaminant hepatotoxins as culprits for kava hepatotoxicity--fact or fiction? Phytother Res. 2013;27(3):472-4.
Teschke, R., Sarris, J., & Lebot, V. (2013). Contaminant hepatotoxins as culprits for kava hepatotoxicity--fact or fiction? Phytotherapy Research : PTR, 27(3), 472-4. https://doi.org/10.1002/ptr.4729
Teschke R, Sarris J, Lebot V. Contaminant Hepatotoxins as Culprits for Kava Hepatotoxicity--fact or Fiction. Phytother Res. 2013;27(3):472-4. PubMed PMID: 22585547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contaminant hepatotoxins as culprits for kava hepatotoxicity--fact or fiction? AU - Teschke,Rolf, AU - Sarris,Jerome, AU - Lebot,Vincent, Y1 - 2012/05/14/ PY - 2012/04/11/received PY - 2012/04/17/accepted PY - 2012/5/16/entrez PY - 2012/5/16/pubmed PY - 2013/6/29/medline SP - 472 EP - 4 JF - Phytotherapy research : PTR JO - Phytother Res VL - 27 IS - 3 N2 - The culprit of kava hepatotoxicity will continue to remain a mystery in humans, if the underlying reaction is of idiosyncratic, unpredictable, and dose-independent nature due potentially to some metabolic aberration in a few individuals emerging from kava use. In addition, kava hepatotoxicity is presently not reproducible experimentally in preclinical models, as demonstrated by studies showing whole kava extracts are not hepatotoxic. This led us to propose our 'working hypothesis' that contaminant hepatotoxins including moulds might have caused rare kava hepatotoxicity in humans. Further studies are now warranted to proof or disproof our working hypothesis, because kava hepatotoxicity possibly based on contaminant hepatotoxins could be a preventable disease. In the meantime, however, for minimizing toxicity risk in kava users, a pragmatic approach should focus on the medicinal use of an aqueous extract derived from peeled rhizomes and roots of a non-mouldy noble kava cultivar, limited to maximum 250-mg kavalactones daily for acute or intermittent use. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22585547/Contaminant_hepatotoxins_as_culprits_for_kava_hepatotoxicity__fact_or_fiction L2 - https://doi.org/10.1002/ptr.4729 DB - PRIME DP - Unbound Medicine ER -