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Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicle.
J Agric Food Chem. 2012 Jul 25; 60(29):7137-41.JA

Abstract

A new microemulsions system of curcumin (CUR-MEs) was successfully developed to improve the solubility and bioavailability of curcumin. Several formulations of the microemulsions system were prepared and evaluated using different ratios of oils, surfactants, and co-surfactants (S&CoS). The optimal formulation, which consists of Capryol 90 (oil), Cremophor RH40 (surfactant), and Transcutol P aqueous solution (co-surfactant), could enhance the solubility of curcumin up to 32.5 mg/mL. The pharmacokinetic study of microemulsions was performed in rats compared to the corresponding suspension. The stability of microemulsions after dilution was excellence. Microemulsions have significantly increased the C(max) and area under the curve (AUC) in comparison to that in suspension (p < 0.05). The relative bioavailability of curcumin in microemulsions was 22.6-fold higher than that in suspension. The results indicated that the CUR-MEs could be used as an effective formulation for enhancing the oral bioavailability of curcumin.

Authors+Show Affiliations

College of Pharmacy, and Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, People's Republic of China. hbupharm@126.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22587560

Citation

Hu, Liandong, et al. "Preparation and Enhancement of Oral Bioavailability of Curcumin Using Microemulsions Vehicle." Journal of Agricultural and Food Chemistry, vol. 60, no. 29, 2012, pp. 7137-41.
Hu L, Jia Y, Niu F, et al. Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicle. J Agric Food Chem. 2012;60(29):7137-41.
Hu, L., Jia, Y., Niu, F., Jia, Z., Yang, X., & Jiao, K. (2012). Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicle. Journal of Agricultural and Food Chemistry, 60(29), 7137-41. https://doi.org/10.1021/jf204078t
Hu L, et al. Preparation and Enhancement of Oral Bioavailability of Curcumin Using Microemulsions Vehicle. J Agric Food Chem. 2012 Jul 25;60(29):7137-41. PubMed PMID: 22587560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicle. AU - Hu,Liandong, AU - Jia,Yanhong, AU - Niu,Feng, AU - Jia,Zheng, AU - Yang,Xun, AU - Jiao,Kuiliang, Y1 - 2012/07/10/ PY - 2012/5/17/entrez PY - 2012/5/17/pubmed PY - 2012/12/10/medline SP - 7137 EP - 41 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 60 IS - 29 N2 - A new microemulsions system of curcumin (CUR-MEs) was successfully developed to improve the solubility and bioavailability of curcumin. Several formulations of the microemulsions system were prepared and evaluated using different ratios of oils, surfactants, and co-surfactants (S&CoS). The optimal formulation, which consists of Capryol 90 (oil), Cremophor RH40 (surfactant), and Transcutol P aqueous solution (co-surfactant), could enhance the solubility of curcumin up to 32.5 mg/mL. The pharmacokinetic study of microemulsions was performed in rats compared to the corresponding suspension. The stability of microemulsions after dilution was excellence. Microemulsions have significantly increased the C(max) and area under the curve (AUC) in comparison to that in suspension (p < 0.05). The relative bioavailability of curcumin in microemulsions was 22.6-fold higher than that in suspension. The results indicated that the CUR-MEs could be used as an effective formulation for enhancing the oral bioavailability of curcumin. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/22587560/Preparation_and_enhancement_of_oral_bioavailability_of_curcumin_using_microemulsions_vehicle_ L2 - https://doi.org/10.1021/jf204078t DB - PRIME DP - Unbound Medicine ER -