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Risk, characteristics, and prognosis of breast cancer after Hodgkin's lymphoma.
Oncologist 2012; 17(6):783-91O

Abstract

PURPOSE

To assess breast cancer (BC) risk after Hodgkin's lymphoma (HL) and compare characteristics, risk of second BC, and prognosis of patients with these BCs with patients with first primary BC.

PATIENTS AND METHODS

We considered all 9,620 women with HL recorded in the Surveillance, Epidemiology and End Results dataset in 1973-2007. We calculated age-period standardized incidence ratios of BC. We compared patient, tumor, and treatment characteristics, risk of second BC, and prognosis between patients with BC after HL (n = 316) and patients with other BCs occurring during the same period (n = 450,413) using logistic regression and Cox models adjusted for confounders.

RESULTS

HL patients had a 2.4-fold higher risk for developing BC (95% confidence interval [CI], 2.2-2.7) than the general population. Age at HL diagnosis and radiation therapy influenced this risk. Compared with first primary BCs, BCs after HL were diagnosed at a younger age, at an earlier stage, were less frequently hormone receptor positive, were located more frequently in external quadrants, and were less frequently treated using radiotherapy. These patients had a higher risk (adjusted hazard ratio [HR], 2.85; 95% CI, 1.79-4.53) for developing a second BC and had a higher BC mortality risk (adjusted HR, 1.36; 95% CI, 1.05-1.76). The higher mortality risk was only partly explained by the higher occurrence rate of a second BC.

CONCLUSION

HL survivors have a higher risk for developing BC, their BCs are more aggressive, they have a higher risk for a second BC occurrence, and they have a poorer prognosis. Guidelines of care should be adapted to decrease the impact of BC in these high-risk patients.

Authors+Show Affiliations

Geneva Cancer Registry, 55 Boulevard de la Cluse, Geneva, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22588325

Citation

Veit-Rubin, Nikolaus, et al. "Risk, Characteristics, and Prognosis of Breast Cancer After Hodgkin's Lymphoma." The Oncologist, vol. 17, no. 6, 2012, pp. 783-91.
Veit-Rubin N, Rapiti E, Usel M, et al. Risk, characteristics, and prognosis of breast cancer after Hodgkin's lymphoma. Oncologist. 2012;17(6):783-91.
Veit-Rubin, N., Rapiti, E., Usel, M., Benhamou, S., Vinh-Hung, V., Vlastos, G., & Bouchardy, C. (2012). Risk, characteristics, and prognosis of breast cancer after Hodgkin's lymphoma. The Oncologist, 17(6), pp. 783-91. doi:10.1634/theoncologist.2011-0451.
Veit-Rubin N, et al. Risk, Characteristics, and Prognosis of Breast Cancer After Hodgkin's Lymphoma. Oncologist. 2012;17(6):783-91. PubMed PMID: 22588325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk, characteristics, and prognosis of breast cancer after Hodgkin's lymphoma. AU - Veit-Rubin,Nikolaus, AU - Rapiti,Elisabetta, AU - Usel,Massimo, AU - Benhamou,Simone, AU - Vinh-Hung,Vincent, AU - Vlastos,Georges, AU - Bouchardy,Christine, Y1 - 2012/05/15/ PY - 2012/5/17/entrez PY - 2012/5/17/pubmed PY - 2012/11/13/medline SP - 783 EP - 91 JF - The oncologist JO - Oncologist VL - 17 IS - 6 N2 - PURPOSE: To assess breast cancer (BC) risk after Hodgkin's lymphoma (HL) and compare characteristics, risk of second BC, and prognosis of patients with these BCs with patients with first primary BC. PATIENTS AND METHODS: We considered all 9,620 women with HL recorded in the Surveillance, Epidemiology and End Results dataset in 1973-2007. We calculated age-period standardized incidence ratios of BC. We compared patient, tumor, and treatment characteristics, risk of second BC, and prognosis between patients with BC after HL (n = 316) and patients with other BCs occurring during the same period (n = 450,413) using logistic regression and Cox models adjusted for confounders. RESULTS: HL patients had a 2.4-fold higher risk for developing BC (95% confidence interval [CI], 2.2-2.7) than the general population. Age at HL diagnosis and radiation therapy influenced this risk. Compared with first primary BCs, BCs after HL were diagnosed at a younger age, at an earlier stage, were less frequently hormone receptor positive, were located more frequently in external quadrants, and were less frequently treated using radiotherapy. These patients had a higher risk (adjusted hazard ratio [HR], 2.85; 95% CI, 1.79-4.53) for developing a second BC and had a higher BC mortality risk (adjusted HR, 1.36; 95% CI, 1.05-1.76). The higher mortality risk was only partly explained by the higher occurrence rate of a second BC. CONCLUSION: HL survivors have a higher risk for developing BC, their BCs are more aggressive, they have a higher risk for a second BC occurrence, and they have a poorer prognosis. Guidelines of care should be adapted to decrease the impact of BC in these high-risk patients. SN - 1549-490X UR - https://www.unboundmedicine.com/medline/citation/22588325/Risk_characteristics_and_prognosis_of_breast_cancer_after_Hodgkin's_lymphoma_ L2 - http://theoncologist.alphamedpress.org/cgi/pmidlookup?view=long&pmid=22588325 DB - PRIME DP - Unbound Medicine ER -