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Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes.
Eur J Clin Nutr. 2012 Jul; 66(7):799-805.EJ

Abstract

BACKGROUND/OBJECTIVES

Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects.

SUBJECTS/METHODS

A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100 g of butter and 45 g of carbohydrate in combination with 45 g of whey isolate (iso-meal), whey hydrolysate (hydro-meal), α-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially.

RESULTS

We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso- and lac-meal in the chylomicron-rich fraction (P=0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro- and iso-meal produced a higher insulin response compared with the lac- and CGMP-meal (P<0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period.

CONCLUSIONS

A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response.

Authors+Show Affiliations

Department of Medicine and Endocrinology, MEA, Aarhus University Hospital, Tage-Hansens Gade 2, Aarhus, Denmark. lene.sundahl@ki.au.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22588635

Citation

Mortensen, L S., et al. "Effects of Different Fractions of Whey Protein On Postprandial Lipid and Hormone Responses in Type 2 Diabetes." European Journal of Clinical Nutrition, vol. 66, no. 7, 2012, pp. 799-805.
Mortensen LS, Holmer-Jensen J, Hartvigsen ML, et al. Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. Eur J Clin Nutr. 2012;66(7):799-805.
Mortensen, L. S., Holmer-Jensen, J., Hartvigsen, M. L., Jensen, V. K., Astrup, A., de Vrese, M., Holst, J. J., Thomsen, C., & Hermansen, K. (2012). Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. European Journal of Clinical Nutrition, 66(7), 799-805. https://doi.org/10.1038/ejcn.2012.48
Mortensen LS, et al. Effects of Different Fractions of Whey Protein On Postprandial Lipid and Hormone Responses in Type 2 Diabetes. Eur J Clin Nutr. 2012;66(7):799-805. PubMed PMID: 22588635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. AU - Mortensen,L S, AU - Holmer-Jensen,J, AU - Hartvigsen,M L, AU - Jensen,V K, AU - Astrup,A, AU - de Vrese,M, AU - Holst,J J, AU - Thomsen,C, AU - Hermansen,K, Y1 - 2012/05/16/ PY - 2012/5/17/entrez PY - 2012/5/17/pubmed PY - 2012/11/3/medline SP - 799 EP - 805 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 7 N2 - BACKGROUND/OBJECTIVES: Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects. SUBJECTS/METHODS: A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100 g of butter and 45 g of carbohydrate in combination with 45 g of whey isolate (iso-meal), whey hydrolysate (hydro-meal), α-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially. RESULTS: We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso- and lac-meal in the chylomicron-rich fraction (P=0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro- and iso-meal produced a higher insulin response compared with the lac- and CGMP-meal (P<0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period. CONCLUSIONS: A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/22588635/Effects_of_different_fractions_of_whey_protein_on_postprandial_lipid_and_hormone_responses_in_type_2_diabetes_ L2 - http://dx.doi.org/10.1038/ejcn.2012.48 DB - PRIME DP - Unbound Medicine ER -