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The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for Streptococcus pneumoniae carriage in children.
Pediatr Infect Dis J 2012; 31(9):e163-8PI

Abstract

BACKGROUND

The aim of the study was to investigate whether the 7-valent pneumococcal conjugate vaccine (PCV7) alters common risk factors of nasopharyngeal carriage by Streptococcus pneumoniae in children.

METHODS

From July 2005 through December 2010, we performed a cross-sectional study investigating risk factors associated with pneumococcal carriage in children. Parents of participating children completed questionnaires including whether or not the children received PCV7 vaccination.

RESULTS

Among 9705 children, 20.2% of them received at least 1 dose of the PCV7 vaccine. Multivariate logistic regression models identified older age, having 1 sibling in a family, history of acute otitis media and household exposure to smoking as independent risk factors for pneumococcal carriage in the unvaccinated group, but not associated with pneumococcal carriage in the vaccinated group. The number of siblings ≥2 in a family, history of upper respiratory tract infection and child-care attendance were strong factors associated with pneumococcal carriage in children, regardless of vaccination. In vaccinated group, breast-feeding was associated with increased nonvaccine type pneumococcal carriage, mainly in children with upper respiratory tract infection.

CONCLUSIONS

PCV7 decreased the association between pneumococcal carriage and older age, 1 sibling in a family, history of acute otitis media and household exposure to smoking, but increased the association between pneumococcal carriage and breast-feeding.

Authors+Show Affiliations

Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22592521

Citation

Hsieh, Yu-Chia, et al. "The Impact of the Heptavalent Pneumococcal Conjugate Vaccine On Risk Factors for Streptococcus Pneumoniae Carriage in Children." The Pediatric Infectious Disease Journal, vol. 31, no. 9, 2012, pp. e163-8.
Hsieh YC, Chiu CH, Chang KY, et al. The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for Streptococcus pneumoniae carriage in children. Pediatr Infect Dis J. 2012;31(9):e163-8.
Hsieh, Y. C., Chiu, C. H., Chang, K. Y., Huang, Y. C., Chen, C. J., Kuo, C. Y., ... Lin, T. Y. (2012). The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for Streptococcus pneumoniae carriage in children. The Pediatric Infectious Disease Journal, 31(9), pp. e163-8.
Hsieh YC, et al. The Impact of the Heptavalent Pneumococcal Conjugate Vaccine On Risk Factors for Streptococcus Pneumoniae Carriage in Children. Pediatr Infect Dis J. 2012;31(9):e163-8. PubMed PMID: 22592521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for Streptococcus pneumoniae carriage in children. AU - Hsieh,Yu-Chia, AU - Chiu,Cheng-Hsun, AU - Chang,Kuang-Yi, AU - Huang,Yhu-Chering, AU - Chen,Chih-Jung, AU - Kuo,Chen-Yen, AU - Chen,Po-Yen, AU - Hwang,Kao-Pin, AU - Lin,Tzou-Yien, PY - 2012/5/18/entrez PY - 2012/5/18/pubmed PY - 2013/1/23/medline SP - e163 EP - 8 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 31 IS - 9 N2 - BACKGROUND: The aim of the study was to investigate whether the 7-valent pneumococcal conjugate vaccine (PCV7) alters common risk factors of nasopharyngeal carriage by Streptococcus pneumoniae in children. METHODS: From July 2005 through December 2010, we performed a cross-sectional study investigating risk factors associated with pneumococcal carriage in children. Parents of participating children completed questionnaires including whether or not the children received PCV7 vaccination. RESULTS: Among 9705 children, 20.2% of them received at least 1 dose of the PCV7 vaccine. Multivariate logistic regression models identified older age, having 1 sibling in a family, history of acute otitis media and household exposure to smoking as independent risk factors for pneumococcal carriage in the unvaccinated group, but not associated with pneumococcal carriage in the vaccinated group. The number of siblings ≥2 in a family, history of upper respiratory tract infection and child-care attendance were strong factors associated with pneumococcal carriage in children, regardless of vaccination. In vaccinated group, breast-feeding was associated with increased nonvaccine type pneumococcal carriage, mainly in children with upper respiratory tract infection. CONCLUSIONS: PCV7 decreased the association between pneumococcal carriage and older age, 1 sibling in a family, history of acute otitis media and household exposure to smoking, but increased the association between pneumococcal carriage and breast-feeding. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/22592521/The_impact_of_the_heptavalent_pneumococcal_conjugate_vaccine_on_risk_factors_for_Streptococcus_pneumoniae_carriage_in_children_ L2 - http://Insights.ovid.com/pubmed?pmid=22592521 DB - PRIME DP - Unbound Medicine ER -