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Effect of potent ethyl acetate fraction of Stereospermum suaveolens extract in streptozotocin-induced diabetic rats.
ScientificWorldJournal. 2012; 2012:413196.S

Abstract

To evaluate the antihyperglycemic effect of ethyl acetate fraction of ethanol extract of Stereospermum suaveolens in streptozotocin-(STZ-) induced diabetic rats by acute and subacute models. In this paper, various fractions of ethanol extract of Stereospermum suaveolens were prepared and their effects on blood glucose levels in STZ-induced diabetic rats were studied after a single oral administration (200 mg/kg). Administration of the ethyl acetate fraction at 200 mg/kg once daily for 14 days to STZ-induced diabetic rats was also carried out. The parameters such as the fasting blood glucose, hepatic glycogen content, and pancreatic antioxidant levels were monitored. In the acute study, the ethyl acetate fraction is the most potent in reducing the fasting serum glucose levels of the STZ-induced diabetic rats. The 14-day repeated oral administration of the ethyl acetate fraction significantly reduced the fasting blood glucose and pancreatic TBARS level and significantly increased the liver glycogen, pancreatic superoxide dismutase, and catalase activities as well as reduced glutathione levels. The histopathological studies during the subacute treatment have been shown to ameliorate the STZ-induced histological damage of pancreas. This paper concludes that the ethyl acetate fraction from ethanol extract of Stereospermum suaveolens possesses potent antihyperglycemic and antioxidant properties, thereby substantiating the use of plant in the indigenous system of medicine.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathi Nagara, Mandya, Karnataka-571 422, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22593683

Citation

Balasubramanian, T, et al. "Effect of Potent Ethyl Acetate Fraction of Stereospermum Suaveolens Extract in Streptozotocin-induced Diabetic Rats." TheScientificWorldJournal, vol. 2012, 2012, p. 413196.
Balasubramanian T, Chatterjee TK, Senthilkumar GP, et al. Effect of potent ethyl acetate fraction of Stereospermum suaveolens extract in streptozotocin-induced diabetic rats. ScientificWorldJournal. 2012;2012:413196.
Balasubramanian, T., Chatterjee, T. K., Senthilkumar, G. P., & Mani, T. (2012). Effect of potent ethyl acetate fraction of Stereospermum suaveolens extract in streptozotocin-induced diabetic rats. TheScientificWorldJournal, 2012, 413196. https://doi.org/10.1100/2012/413196
Balasubramanian T, et al. Effect of Potent Ethyl Acetate Fraction of Stereospermum Suaveolens Extract in Streptozotocin-induced Diabetic Rats. ScientificWorldJournal. 2012;2012:413196. PubMed PMID: 22593683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of potent ethyl acetate fraction of Stereospermum suaveolens extract in streptozotocin-induced diabetic rats. AU - Balasubramanian,T, AU - Chatterjee,Tapan Kumar, AU - Senthilkumar,G P, AU - Mani,Tamizh, Y1 - 2012/04/19/ PY - 2011/10/21/received PY - 2011/12/28/accepted PY - 2012/5/18/entrez PY - 2012/5/18/pubmed PY - 2012/10/10/medline SP - 413196 EP - 413196 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 2012 N2 - To evaluate the antihyperglycemic effect of ethyl acetate fraction of ethanol extract of Stereospermum suaveolens in streptozotocin-(STZ-) induced diabetic rats by acute and subacute models. In this paper, various fractions of ethanol extract of Stereospermum suaveolens were prepared and their effects on blood glucose levels in STZ-induced diabetic rats were studied after a single oral administration (200 mg/kg). Administration of the ethyl acetate fraction at 200 mg/kg once daily for 14 days to STZ-induced diabetic rats was also carried out. The parameters such as the fasting blood glucose, hepatic glycogen content, and pancreatic antioxidant levels were monitored. In the acute study, the ethyl acetate fraction is the most potent in reducing the fasting serum glucose levels of the STZ-induced diabetic rats. The 14-day repeated oral administration of the ethyl acetate fraction significantly reduced the fasting blood glucose and pancreatic TBARS level and significantly increased the liver glycogen, pancreatic superoxide dismutase, and catalase activities as well as reduced glutathione levels. The histopathological studies during the subacute treatment have been shown to ameliorate the STZ-induced histological damage of pancreas. This paper concludes that the ethyl acetate fraction from ethanol extract of Stereospermum suaveolens possesses potent antihyperglycemic and antioxidant properties, thereby substantiating the use of plant in the indigenous system of medicine. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/22593683/Effect_of_potent_ethyl_acetate_fraction_of_Stereospermum_suaveolens_extract_in_streptozotocin_induced_diabetic_rats_ L2 - https://doi.org/10.1100/2012/413196 DB - PRIME DP - Unbound Medicine ER -