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Alfuzosin for the treatment of storage symptoms suggestive of overactive bladder.
Expert Opin Pharmacother. 2012 Jun; 13(8):1143-51.EO

Abstract

INTRODUCTION

Antimuscarinics are the mainstay of overactive bladder (OAB) pharmacotherapy although other agents, such as α-adrenergic receptor antagonists, might also be effective. Alfuzosin has α1-adrenoreceptor antagonist activity and is available worldwide for the treatment of lower urinary tract symptoms resulting from benign prostate hyperplasia. Alfuzosin may relieve storage symptoms suggestive of OAB in patients with or without bladder outlet obstruction (BOO).

AREAS COVERED

This paper reviews the available literature on the use of alfuzosin in the treatment of storage symptoms suggestive of OAB. Additionally, the role of α-adrenoreceptor antagonists in the treatment of OAB is reviewed, based on pathophysiology.

EXPERT OPINION

Although alfuzosin is effective against storage symptoms, it does not improve them in all patients with OAB. It is likely that alternative types of therapy, such as antimuscrarinics, need to be co-administered to patients with residual storage symptoms after alfuzosin administration. Alfuzosin can decrease the risk of adverse events associated with antimuscarinics. The sequential use of alfuzosin and antimuscarinics appears to be an appropriate strategy for the treatment of storage symptoms suggestive of OAB related to BOO.

Authors+Show Affiliations

The Catholic University of Korea, School of Medicine, Bucheon St Mary's Hospital, Department of Urology, Seoul, Korea.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22594844

Citation

Cho, Kang Jun, and Joon Chul Kim. "Alfuzosin for the Treatment of Storage Symptoms Suggestive of Overactive Bladder." Expert Opinion On Pharmacotherapy, vol. 13, no. 8, 2012, pp. 1143-51.
Cho KJ, Kim JC. Alfuzosin for the treatment of storage symptoms suggestive of overactive bladder. Expert Opin Pharmacother. 2012;13(8):1143-51.
Cho, K. J., & Kim, J. C. (2012). Alfuzosin for the treatment of storage symptoms suggestive of overactive bladder. Expert Opinion On Pharmacotherapy, 13(8), 1143-51. https://doi.org/10.1517/14656566.2012.682149
Cho KJ, Kim JC. Alfuzosin for the Treatment of Storage Symptoms Suggestive of Overactive Bladder. Expert Opin Pharmacother. 2012;13(8):1143-51. PubMed PMID: 22594844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alfuzosin for the treatment of storage symptoms suggestive of overactive bladder. AU - Cho,Kang Jun, AU - Kim,Joon Chul, PY - 2012/5/19/entrez PY - 2012/5/19/pubmed PY - 2012/9/12/medline SP - 1143 EP - 51 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 13 IS - 8 N2 - INTRODUCTION: Antimuscarinics are the mainstay of overactive bladder (OAB) pharmacotherapy although other agents, such as α-adrenergic receptor antagonists, might also be effective. Alfuzosin has α1-adrenoreceptor antagonist activity and is available worldwide for the treatment of lower urinary tract symptoms resulting from benign prostate hyperplasia. Alfuzosin may relieve storage symptoms suggestive of OAB in patients with or without bladder outlet obstruction (BOO). AREAS COVERED: This paper reviews the available literature on the use of alfuzosin in the treatment of storage symptoms suggestive of OAB. Additionally, the role of α-adrenoreceptor antagonists in the treatment of OAB is reviewed, based on pathophysiology. EXPERT OPINION: Although alfuzosin is effective against storage symptoms, it does not improve them in all patients with OAB. It is likely that alternative types of therapy, such as antimuscrarinics, need to be co-administered to patients with residual storage symptoms after alfuzosin administration. Alfuzosin can decrease the risk of adverse events associated with antimuscarinics. The sequential use of alfuzosin and antimuscarinics appears to be an appropriate strategy for the treatment of storage symptoms suggestive of OAB related to BOO. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/22594844/Alfuzosin_for_the_treatment_of_storage_symptoms_suggestive_of_overactive_bladder_ L2 - https://www.tandfonline.com/doi/full/10.1517/14656566.2012.682149 DB - PRIME DP - Unbound Medicine ER -
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