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Optic disc torsion direction predicts the location of glaucomatous damage in normal-tension glaucoma patients with myopia.
Ophthalmology 2012; 119(9):1844-51O

Abstract

OBJECTIVE

To characterize optic disc tilt and torsion in normal-tension glaucoma (NTG) patients with myopia and to evaluate the relationship between optic disc tilt and torsion with the location of visual field (VF) defect.

DESIGN

Retrospective, case-control design.

PARTICIPANTS

Two hundred twenty-five NTG patients.

METHODS

Patients were divided into a myopic NTG group (spherical equivalent more than -2.00 diopters [D] or axial length more than 24.0 mm; n = 166) and nonmyopic NTG group (spherical equivalent less than -0.50 D or axial length less than 24.0 mm; n = 59). Disc tilt, which was identified by the tilt ratio, disc torsion, and area of peripapillary atrophy (PPA), was measured from disc photographs. Patients were divided further into superior and inferior defect groups according to the location of the VF defect in the pattern deviation map. Logistic regression analysis was used to determine the relationship between ocular factors, including tilt ratio, torsion degree, and the VF defect location.

MAIN OUTCOME MEASURES

Tilt ratio, torsion degree, PPA area, and location of VF defect.

RESULTS

Among 225 NTG eyes, 166 (73.8%) were myopic eyes. The myopic NTG group was significantly younger (42.85 years) than the nonmyopic NTG group (60.73 years). Disc tilt (45.8%) and torsion (75.9%) were significantly more prevalent in the myopic NTG group than in the nonmyopic NTG group. Although just short of statistical significance (P = 0.057), PPA area was larger in the myopic NTG group. The VF defect location was significantly different between the 2 groups, with superior defects more prevalent in the myopic NTG group (69.9%; P<0.001). Torsion degree was significantly different in the superior defect group (18.45°) compared with the inferior defect group (-3.81°; P = 0.001). Torsion degree was the only factor related to VF defect location in both univariate (P = 0.001) and multivariate (P = 0.014) logistic regression analyses.

CONCLUSIONS

Korean NTG patients had a high prevalence of myopia and young age. Optic disc tilt and torsion were highly prevalent in Korean NTG patients with myopia. The direction of the optic disc torsion may predict the location of damage.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22595297

Citation

Park, Hae-Young L., et al. "Optic Disc Torsion Direction Predicts the Location of Glaucomatous Damage in Normal-tension Glaucoma Patients With Myopia." Ophthalmology, vol. 119, no. 9, 2012, pp. 1844-51.
Park HY, Lee K, Park CK. Optic disc torsion direction predicts the location of glaucomatous damage in normal-tension glaucoma patients with myopia. Ophthalmology. 2012;119(9):1844-51.
Park, H. Y., Lee, K., & Park, C. K. (2012). Optic disc torsion direction predicts the location of glaucomatous damage in normal-tension glaucoma patients with myopia. Ophthalmology, 119(9), pp. 1844-51. doi:10.1016/j.ophtha.2012.03.006.
Park HY, Lee K, Park CK. Optic Disc Torsion Direction Predicts the Location of Glaucomatous Damage in Normal-tension Glaucoma Patients With Myopia. Ophthalmology. 2012;119(9):1844-51. PubMed PMID: 22595297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optic disc torsion direction predicts the location of glaucomatous damage in normal-tension glaucoma patients with myopia. AU - Park,Hae-Young L, AU - Lee,Kook, AU - Park,Chan Kee, Y1 - 2012/05/15/ PY - 2011/10/26/received PY - 2012/03/06/revised PY - 2012/03/06/accepted PY - 2012/5/19/entrez PY - 2012/5/19/pubmed PY - 2012/12/10/medline SP - 1844 EP - 51 JF - Ophthalmology JO - Ophthalmology VL - 119 IS - 9 N2 - OBJECTIVE: To characterize optic disc tilt and torsion in normal-tension glaucoma (NTG) patients with myopia and to evaluate the relationship between optic disc tilt and torsion with the location of visual field (VF) defect. DESIGN: Retrospective, case-control design. PARTICIPANTS: Two hundred twenty-five NTG patients. METHODS: Patients were divided into a myopic NTG group (spherical equivalent more than -2.00 diopters [D] or axial length more than 24.0 mm; n = 166) and nonmyopic NTG group (spherical equivalent less than -0.50 D or axial length less than 24.0 mm; n = 59). Disc tilt, which was identified by the tilt ratio, disc torsion, and area of peripapillary atrophy (PPA), was measured from disc photographs. Patients were divided further into superior and inferior defect groups according to the location of the VF defect in the pattern deviation map. Logistic regression analysis was used to determine the relationship between ocular factors, including tilt ratio, torsion degree, and the VF defect location. MAIN OUTCOME MEASURES: Tilt ratio, torsion degree, PPA area, and location of VF defect. RESULTS: Among 225 NTG eyes, 166 (73.8%) were myopic eyes. The myopic NTG group was significantly younger (42.85 years) than the nonmyopic NTG group (60.73 years). Disc tilt (45.8%) and torsion (75.9%) were significantly more prevalent in the myopic NTG group than in the nonmyopic NTG group. Although just short of statistical significance (P = 0.057), PPA area was larger in the myopic NTG group. The VF defect location was significantly different between the 2 groups, with superior defects more prevalent in the myopic NTG group (69.9%; P<0.001). Torsion degree was significantly different in the superior defect group (18.45°) compared with the inferior defect group (-3.81°; P = 0.001). Torsion degree was the only factor related to VF defect location in both univariate (P = 0.001) and multivariate (P = 0.014) logistic regression analyses. CONCLUSIONS: Korean NTG patients had a high prevalence of myopia and young age. Optic disc tilt and torsion were highly prevalent in Korean NTG patients with myopia. The direction of the optic disc torsion may predict the location of damage. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/22595297/Optic_disc_torsion_direction_predicts_the_location_of_glaucomatous_damage_in_normal_tension_glaucoma_patients_with_myopia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(12)00231-X DB - PRIME DP - Unbound Medicine ER -