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Dietary intervention focused on phosphate intake in hemodialysis patients with hyperphosphoremia.
Clin Nephrol. 2012 Jun; 77(6):476-83.CN

Abstract

BACKGROUND

Elevated serum phosphorus has been identified as a cardiovascular risk factor. This study aimed to assess the effectiveness of dietary intervention to reduce phosphorus intake and to improve the calcium-phosphorus metabolism in hemodialysis patients.

DESIGN

Patients were included in a 6-month, 2-group experimental study if their previous 3-month average serum phosphorus was over 5.5 mg/dl. Patients were allocated to intensive dietary intervention or usual dietary recommendations. The clinical end-points were the multivariate-adjusted change in serum phosphorus and the number of patients who achieved serum phosphorus levels of < 5.5 mg/dl and serum phosphorus levels of < 5 mg/dl.

RESULTS

80 dialysis patients completed the study, 41 in the experimental group and 39 in the control group. After 6 months, phosphorus intake (702 ± 168 vs. 872 ± 242 mg/24 h; p = 0.002) was lower in the experimental group than in the control group, with no inter-group differences in protein-caloric intake. Serum phosphorus decreased 1.67 mg/dl in the experimental group and 0.58 mg/dl in the control group (multivariate-adjusted difference 0.93 mg/ dl; 95% CI 0.34 - 1.52; p = 0.003). Serum phosphorus < 5.5 mg/dl and serum phosphorus < 5 mg/dl were attained more frequently in the experimental group (51 vs. 18%, p = 0.002 and 31.7 vs. 15.4%, p = 0.08 respectively).

CONCLUSIONS

Intensive dietary intervention focusing on phosphorus intake may be useful to reduce phosphorus retention and to improve calcium-phosphorus metabolism in hemodialysis patients.

Authors+Show Affiliations

Miguel Servet University, Clinic University, San Juan de Dios, Aragón, Spain. luis.lou@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

22595390

Citation

Lou, L M., et al. "Dietary Intervention Focused On Phosphate Intake in Hemodialysis Patients With Hyperphosphoremia." Clinical Nephrology, vol. 77, no. 6, 2012, pp. 476-83.
Lou LM, Caverni A, Gimeno JA, et al. Dietary intervention focused on phosphate intake in hemodialysis patients with hyperphosphoremia. Clin Nephrol. 2012;77(6):476-83.
Lou, L. M., Caverni, A., Gimeno, J. A., Moreno, R., Pérez, J., Alvarez, R., Campos, B., García, M., Gutiérrez, A., Bielsa, S., Castilla, J., Sanz, A., & Martin, F. (2012). Dietary intervention focused on phosphate intake in hemodialysis patients with hyperphosphoremia. Clinical Nephrology, 77(6), 476-83.
Lou LM, et al. Dietary Intervention Focused On Phosphate Intake in Hemodialysis Patients With Hyperphosphoremia. Clin Nephrol. 2012;77(6):476-83. PubMed PMID: 22595390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intervention focused on phosphate intake in hemodialysis patients with hyperphosphoremia. AU - Lou,L M, AU - Caverni,A, AU - Gimeno,J A, AU - Moreno,R, AU - Pérez,J, AU - Alvarez,R, AU - Campos,B, AU - García,M, AU - Gutiérrez,A, AU - Bielsa,S, AU - Castilla,J, AU - Sanz,A, AU - Martin,F, AU - ,, PY - 2012/5/19/entrez PY - 2012/5/19/pubmed PY - 2012/8/8/medline SP - 476 EP - 83 JF - Clinical nephrology JO - Clin Nephrol VL - 77 IS - 6 N2 - BACKGROUND: Elevated serum phosphorus has been identified as a cardiovascular risk factor. This study aimed to assess the effectiveness of dietary intervention to reduce phosphorus intake and to improve the calcium-phosphorus metabolism in hemodialysis patients. DESIGN: Patients were included in a 6-month, 2-group experimental study if their previous 3-month average serum phosphorus was over 5.5 mg/dl. Patients were allocated to intensive dietary intervention or usual dietary recommendations. The clinical end-points were the multivariate-adjusted change in serum phosphorus and the number of patients who achieved serum phosphorus levels of < 5.5 mg/dl and serum phosphorus levels of < 5 mg/dl. RESULTS: 80 dialysis patients completed the study, 41 in the experimental group and 39 in the control group. After 6 months, phosphorus intake (702 ± 168 vs. 872 ± 242 mg/24 h; p = 0.002) was lower in the experimental group than in the control group, with no inter-group differences in protein-caloric intake. Serum phosphorus decreased 1.67 mg/dl in the experimental group and 0.58 mg/dl in the control group (multivariate-adjusted difference 0.93 mg/ dl; 95% CI 0.34 - 1.52; p = 0.003). Serum phosphorus < 5.5 mg/dl and serum phosphorus < 5 mg/dl were attained more frequently in the experimental group (51 vs. 18%, p = 0.002 and 31.7 vs. 15.4%, p = 0.08 respectively). CONCLUSIONS: Intensive dietary intervention focusing on phosphorus intake may be useful to reduce phosphorus retention and to improve calcium-phosphorus metabolism in hemodialysis patients. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/22595390/Dietary_intervention_focused_on_phosphate_intake_in_hemodialysis_patients_with_hyperphosphoremia_ L2 - http://www.dustri.com/nc/journals-in-english.html?artId=9306 DB - PRIME DP - Unbound Medicine ER -