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Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome.
J Pediatr Surg. 2012 May; 47(5):931-7.JP

Abstract

AIM

The aim of this study is to report 5-year outcomes in patients who have received serial transverse enteroplasty (STEP) using clinical and biochemical assessments of intestinal function.

METHODS

Thirty-one STEP procedures have been performed at our institution. Twelve patients who received STEP before January 2005 were analyzed. Clinical and biochemical outcomes were performed pre-STEP and post-STEP on an annual basis. Paired t tests were used to compare post-STEP outcomes to pre-STEP values (P < .05 was significant).

MAIN RESULTS

There were 12 patients (3 females; median age, 5.5 months). Serial transverse enteroplasty resulted in mean increase in length of dilated bowel segment of 89% ± 26% and increase in total small bowel length of 46% ± 40%. Two patients received liver-intestinal transplants post-STEP (at 4 and 5 months), and 2 patients died of liver failure at 3 and 8 months. The remaining 8 of 12 patients all show stable intestinal absorptive capacity (data not shown). Of 8 patients, 7 were weaned off parenteral nutrition by 4 years. No patient has required repeat STEP or bowel tapering. Two patients developed staple line leak, and 1 patient developed gastrointestinal bleed from staple line ulcers.

CONCLUSION

This report represents the largest series of STEP patients followed up beyond 5 years. Long-term clinical, biochemical, and radiologic outcomes appear to be robust.

Authors+Show Affiliations

Division of General Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

22595576

Citation

Oliveira, Carol, et al. "Five-year Outcomes After Serial Transverse Enteroplasty in Children With Short Bowel Syndrome." Journal of Pediatric Surgery, vol. 47, no. 5, 2012, pp. 931-7.
Oliveira C, de Silva N, Wales PW. Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome. J Pediatr Surg. 2012;47(5):931-7.
Oliveira, C., de Silva, N., & Wales, P. W. (2012). Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome. Journal of Pediatric Surgery, 47(5), 931-7. https://doi.org/10.1016/j.jpedsurg.2012.01.049
Oliveira C, de Silva N, Wales PW. Five-year Outcomes After Serial Transverse Enteroplasty in Children With Short Bowel Syndrome. J Pediatr Surg. 2012;47(5):931-7. PubMed PMID: 22595576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome. AU - Oliveira,Carol, AU - de Silva,Nicole, AU - Wales,Paul W, PY - 2012/01/16/received PY - 2012/01/26/accepted PY - 2012/5/19/entrez PY - 2012/5/19/pubmed PY - 2012/9/25/medline SP - 931 EP - 7 JF - Journal of pediatric surgery JO - J Pediatr Surg VL - 47 IS - 5 N2 - AIM: The aim of this study is to report 5-year outcomes in patients who have received serial transverse enteroplasty (STEP) using clinical and biochemical assessments of intestinal function. METHODS: Thirty-one STEP procedures have been performed at our institution. Twelve patients who received STEP before January 2005 were analyzed. Clinical and biochemical outcomes were performed pre-STEP and post-STEP on an annual basis. Paired t tests were used to compare post-STEP outcomes to pre-STEP values (P < .05 was significant). MAIN RESULTS: There were 12 patients (3 females; median age, 5.5 months). Serial transverse enteroplasty resulted in mean increase in length of dilated bowel segment of 89% ± 26% and increase in total small bowel length of 46% ± 40%. Two patients received liver-intestinal transplants post-STEP (at 4 and 5 months), and 2 patients died of liver failure at 3 and 8 months. The remaining 8 of 12 patients all show stable intestinal absorptive capacity (data not shown). Of 8 patients, 7 were weaned off parenteral nutrition by 4 years. No patient has required repeat STEP or bowel tapering. Two patients developed staple line leak, and 1 patient developed gastrointestinal bleed from staple line ulcers. CONCLUSION: This report represents the largest series of STEP patients followed up beyond 5 years. Long-term clinical, biochemical, and radiologic outcomes appear to be robust. SN - 1531-5037 UR - https://www.unboundmedicine.com/medline/citation/22595576/Five_year_outcomes_after_serial_transverse_enteroplasty_in_children_with_short_bowel_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3468(12)00118-2 DB - PRIME DP - Unbound Medicine ER -