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Genetical factors--other than HLA-B27--in "HLA-B27-associated diseases".
Scand J Rheumatol Suppl. 1990; 87:122-6; discussion 126.SJ

Abstract

All studies among acute anterior uveitis (AAU) and ankylosing spondylitis (AS) agree on the importance of and high association with HLA-B27. However, the majority (greater than 95%) of the HLA-B27+ population will never develop such disease. There are two--generally accepted--important factors increasing the relative risk for developing AAU or AS. Firstly being HLA-B27 positive and secondly being a first degree relative of a patient with AAU or AS. The association with HLA-B27 is probably based on particular HLA-B27 properties, but not on a preferential association with one of the HLA-B27 subtypes. The subtypes are equally distributed among normal controls and AAU or AS patients. Family investigations among the relatives of AAU and AS patients predict the existence of other pathogenic factors in addition to HLA-B27. Strong though circumstantial evidence for a genetical origin of these factors was found in the families. It was also found in AAU and AS family investigations that associations with other polymorphic causal genes on chromosome 6 that are in linkage disequilibrium with HLA-B27 are highly improbable.

Authors+Show Affiliations

Derhaag PJ
Netherlands Ophthalmic Research Institute, Amsterdam.

MeSH

Acute DiseaseChromosomes, Human, Pair 6FamilyGene FrequencyGenes, MHC Class IGenetic Predisposition to DiseaseHLA-B27 AntigenHaplotypesHumansRisk FactorsSpondylitis, AnkylosingUveitis, Anterior

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

2259881

Citation

Derhaag, P J.. "Genetical Factors--other Than HLA-B27--in "HLA-B27-associated Diseases"." Scandinavian Journal of Rheumatology. Supplement, vol. 87, 1990, pp. 122-6; discussion 126.
Derhaag PJ. Genetical factors--other than HLA-B27--in "HLA-B27-associated diseases". Scand J Rheumatol Suppl. 1990;87:122-6; discussion 126.
Derhaag, P. J. (1990). Genetical factors--other than HLA-B27--in "HLA-B27-associated diseases". Scandinavian Journal of Rheumatology. Supplement, 87, 122-6; discussion 126.
Derhaag PJ. Genetical Factors--other Than HLA-B27--in "HLA-B27-associated Diseases". Scand J Rheumatol Suppl. 1990;87:122-6; discussion 126. PubMed PMID: 2259881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetical factors--other than HLA-B27--in "HLA-B27-associated diseases". A1 - Derhaag,P J, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 122-6; discussion 126 JF - Scandinavian journal of rheumatology. Supplement JO - Scand J Rheumatol Suppl VL - 87 N2 - All studies among acute anterior uveitis (AAU) and ankylosing spondylitis (AS) agree on the importance of and high association with HLA-B27. However, the majority (greater than 95%) of the HLA-B27+ population will never develop such disease. There are two--generally accepted--important factors increasing the relative risk for developing AAU or AS. Firstly being HLA-B27 positive and secondly being a first degree relative of a patient with AAU or AS. The association with HLA-B27 is probably based on particular HLA-B27 properties, but not on a preferential association with one of the HLA-B27 subtypes. The subtypes are equally distributed among normal controls and AAU or AS patients. Family investigations among the relatives of AAU and AS patients predict the existence of other pathogenic factors in addition to HLA-B27. Strong though circumstantial evidence for a genetical origin of these factors was found in the families. It was also found in AAU and AS family investigations that associations with other polymorphic causal genes on chromosome 6 that are in linkage disequilibrium with HLA-B27 are highly improbable. SN - 0301-3847 UR - https://www.unboundmedicine.com/medline/citation/2259881/Genetical_factors__other_than_HLA_B27__in_"HLA_B27_associated_diseases"_ DB - PRIME DP - Unbound Medicine ER -