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Vasectomy and the risk of prostate cancer.
Am J Epidemiol 1990; 132(6):1051-5; discussion 1062-5AJ

Abstract

An unexpected association between history of vasectomy and increased risk of prostate cancer emerged when multiple comparisons were carried out in data collected from 1976-1988 in a US hospital-based case-control study of many diseases and exposures. The association was assessed in detail in these data, in a comparison of 220 men with first episodes of prostate cancer with 571 noncancer controls and 960 cancer controls. The age-adjusted relative risk of prostate cancer was 5.3 (95% confidence interval 2.7-10) when noncancer controls were used and 3.5 (95 percent confidence interval 2.1-6.0) when cancer controls were used. The magnitude of the relative risk estimate appeared to be unrelated to the length of the interval after vasectomy. Allowance for several factors did not alter the estimates, but we did not have information on testosterone level or sexual activity, which may have been confounding factors. The association was stronger among men most likely to have been under more intensive medical surveillance; selective detection of asymptomatic cancer in such men would have led to an excess of cases. Further studies are needed to rule out chance, bias from medical surveillance, and uncontrolled confounding as explanations for the finding.

Authors+Show Affiliations

Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline 02146.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2260536

Citation

Rosenberg, L, et al. "Vasectomy and the Risk of Prostate Cancer." American Journal of Epidemiology, vol. 132, no. 6, 1990, pp. 1051-5; discussion 1062-5.
Rosenberg L, Palmer JR, Zauber AG, et al. Vasectomy and the risk of prostate cancer. Am J Epidemiol. 1990;132(6):1051-5; discussion 1062-5.
Rosenberg, L., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Stolley, P. D., & Shapiro, S. (1990). Vasectomy and the risk of prostate cancer. American Journal of Epidemiology, 132(6), pp. 1051-5; discussion 1062-5.
Rosenberg L, et al. Vasectomy and the Risk of Prostate Cancer. Am J Epidemiol. 1990;132(6):1051-5; discussion 1062-5. PubMed PMID: 2260536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy and the risk of prostate cancer. AU - Rosenberg,L, AU - Palmer,J R, AU - Zauber,A G, AU - Warshauer,M E, AU - Stolley,P D, AU - Shapiro,S, PY - 1990/12/1/pubmed PY - 1990/12/1/medline PY - 1990/12/1/entrez KW - Androgens KW - Biology KW - Cancer KW - Case Control Studies KW - Control Groups KW - Data Analysis KW - Data Collection KW - Demographic Factors KW - Diseases KW - Endocrine System KW - Epidemiologic Methods KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Hormones KW - Incidence KW - Male Sterilization KW - Measurement KW - Neoplasms KW - Physiology KW - Population KW - Prostate--changes KW - Research Methodology KW - Risk Factors KW - Sterilization, Sexual KW - Studies KW - Testosterone--analysis KW - Urogenital System KW - Vasectomy SP - 1051-5; discussion 1062-5 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 132 IS - 6 N2 - An unexpected association between history of vasectomy and increased risk of prostate cancer emerged when multiple comparisons were carried out in data collected from 1976-1988 in a US hospital-based case-control study of many diseases and exposures. The association was assessed in detail in these data, in a comparison of 220 men with first episodes of prostate cancer with 571 noncancer controls and 960 cancer controls. The age-adjusted relative risk of prostate cancer was 5.3 (95% confidence interval 2.7-10) when noncancer controls were used and 3.5 (95 percent confidence interval 2.1-6.0) when cancer controls were used. The magnitude of the relative risk estimate appeared to be unrelated to the length of the interval after vasectomy. Allowance for several factors did not alter the estimates, but we did not have information on testosterone level or sexual activity, which may have been confounding factors. The association was stronger among men most likely to have been under more intensive medical surveillance; selective detection of asymptomatic cancer in such men would have led to an excess of cases. Further studies are needed to rule out chance, bias from medical surveillance, and uncontrolled confounding as explanations for the finding. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/2260536/Vasectomy_and_the_risk_of_prostate_cancer_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a115746 DB - PRIME DP - Unbound Medicine ER -