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Vasectomy and prostate cancer risk.
Am J Epidemiol 1990; 132(6):1056-61; discussion 1062-5AJ

Abstract

To assess the hypothesis that a history of vasectomy is a risk factor in the etiology of prostate cancer, the authors conducted a case-control study at Roswell Park Memorial Institute, Buffalo, NY, between 1982 and 1988. From epidemiologic data routinely collected from entering patients, information on vasectomy history and other data were obtained for 614 patients with prostate cancer and 2,588 comparable control subjects with cancer at another site. Age-specific and age-adjusted relative risks were calculated. Increased risk (relative risk = 1.7, 95% confidence interval 1.1-2.6) was found for reporting vasectomy at any age. Age-adjusted relative risk of 2.2 (95% confidence interval 1.0-4.6) was observed for men who reported vasectomy 13-18 years before diagnosis. A significant trend in the association of years since vasectomy and risk also was observed. Cases and controls were found to be nearly identical with respect to education, income, race, marital history, and number of children. A difference in smoking histories of cases and controls was found not to confound the observed associations. These data may suggest the importance of further epidemiologic and biologic research on vasectomy as a risk factor for prostate cancer.

Authors+Show Affiliations

Dept. of Epidemiology, Roswell Park Memorial Inst., Buffalo, NY 14263.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2260537

Citation

Mettlin, C, et al. "Vasectomy and Prostate Cancer Risk." American Journal of Epidemiology, vol. 132, no. 6, 1990, pp. 1056-61; discussion 1062-5.
Mettlin C, Natarajan N, Huben R. Vasectomy and prostate cancer risk. Am J Epidemiol. 1990;132(6):1056-61; discussion 1062-5.
Mettlin, C., Natarajan, N., & Huben, R. (1990). Vasectomy and prostate cancer risk. American Journal of Epidemiology, 132(6), pp. 1056-61; discussion 1062-5.
Mettlin C, Natarajan N, Huben R. Vasectomy and Prostate Cancer Risk. Am J Epidemiol. 1990;132(6):1056-61; discussion 1062-5. PubMed PMID: 2260537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy and prostate cancer risk. AU - Mettlin,C, AU - Natarajan,N, AU - Huben,R, PY - 1990/12/1/pubmed PY - 1990/12/1/medline PY - 1990/12/1/entrez KW - Americas KW - Bias KW - Biology KW - Cancer KW - Case Control Studies KW - Control Groups KW - Data Analysis KW - Data Collection KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Epidemiologic Methods KW - Error Sources KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Male Sterilization KW - Measurement KW - Neoplasms KW - New York KW - North America KW - Northern America KW - Physiology KW - Population KW - Prostate KW - Reliability KW - Research Methodology KW - Risk Factors KW - Sterilization, Sexual KW - Studies KW - United States KW - Urogenital System KW - Vasectomy--side effects SP - 1056-61; discussion 1062-5 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 132 IS - 6 N2 - To assess the hypothesis that a history of vasectomy is a risk factor in the etiology of prostate cancer, the authors conducted a case-control study at Roswell Park Memorial Institute, Buffalo, NY, between 1982 and 1988. From epidemiologic data routinely collected from entering patients, information on vasectomy history and other data were obtained for 614 patients with prostate cancer and 2,588 comparable control subjects with cancer at another site. Age-specific and age-adjusted relative risks were calculated. Increased risk (relative risk = 1.7, 95% confidence interval 1.1-2.6) was found for reporting vasectomy at any age. Age-adjusted relative risk of 2.2 (95% confidence interval 1.0-4.6) was observed for men who reported vasectomy 13-18 years before diagnosis. A significant trend in the association of years since vasectomy and risk also was observed. Cases and controls were found to be nearly identical with respect to education, income, race, marital history, and number of children. A difference in smoking histories of cases and controls was found not to confound the observed associations. These data may suggest the importance of further epidemiologic and biologic research on vasectomy as a risk factor for prostate cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/2260537/Vasectomy_and_prostate_cancer_risk_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a115747 DB - PRIME DP - Unbound Medicine ER -