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Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
J Nat Prod. 2012 Jun 22; 75(6):1145-59.JN

Abstract

Twenty-six new diterpenoid alkaloids, 1-26 (1-4: hetisan-type C(20)-diterpenoid alkaloids; 5-26: aconitane C(19)-diterpenoid alkaloids), and two known analogues, hypaconitine 27 and benzoylmesaconine 28, have been isolated from a water extract of the lateral root of Aconitum carmichaelii. Compounds 7 and 8 are rare examples of conformational isomers obtained from the same material. The conformation and conformational transformation of ring A in the C(19)-diterpenoid alkaloids are discussed on the basis of NMR data analysis in combination with single-crystal X-ray crystallography of 6 and 27 by anomalous scattering of Cu Kα radiation. In preliminary analgesic and toxicity assays, the isomer with ring A in the chair conformation (8 or 27) was found to be more active than that with ring A in the boat conformation (7 or 27a). In addition, 15, 16, and 19 showed neuroprotective activity.

Authors+Show Affiliations

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22607495

Citation

Jiang, Bingya, et al. "Diterpenoid Alkaloids From the Lateral Root of Aconitum Carmichaelii." Journal of Natural Products, vol. 75, no. 6, 2012, pp. 1145-59.
Jiang B, Lin S, Zhu C, et al. Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii. J Nat Prod. 2012;75(6):1145-59.
Jiang, B., Lin, S., Zhu, C., Wang, S., Wang, Y., Chen, M., Zhang, J., Hu, J., Chen, N., Yang, Y., & Shi, J. (2012). Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii. Journal of Natural Products, 75(6), 1145-59. https://doi.org/10.1021/np300225t
Jiang B, et al. Diterpenoid Alkaloids From the Lateral Root of Aconitum Carmichaelii. J Nat Prod. 2012 Jun 22;75(6):1145-59. PubMed PMID: 22607495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii. AU - Jiang,Bingya, AU - Lin,Sheng, AU - Zhu,Chenggen, AU - Wang,Sujuan, AU - Wang,Yanan, AU - Chen,Minghua, AU - Zhang,Jianjun, AU - Hu,Jinfeng, AU - Chen,Naihong, AU - Yang,Yongchun, AU - Shi,Jiangong, Y1 - 2012/05/18/ PY - 2012/5/22/entrez PY - 2012/5/23/pubmed PY - 2012/9/22/medline SP - 1145 EP - 59 JF - Journal of natural products JO - J Nat Prod VL - 75 IS - 6 N2 - Twenty-six new diterpenoid alkaloids, 1-26 (1-4: hetisan-type C(20)-diterpenoid alkaloids; 5-26: aconitane C(19)-diterpenoid alkaloids), and two known analogues, hypaconitine 27 and benzoylmesaconine 28, have been isolated from a water extract of the lateral root of Aconitum carmichaelii. Compounds 7 and 8 are rare examples of conformational isomers obtained from the same material. The conformation and conformational transformation of ring A in the C(19)-diterpenoid alkaloids are discussed on the basis of NMR data analysis in combination with single-crystal X-ray crystallography of 6 and 27 by anomalous scattering of Cu Kα radiation. In preliminary analgesic and toxicity assays, the isomer with ring A in the chair conformation (8 or 27) was found to be more active than that with ring A in the boat conformation (7 or 27a). In addition, 15, 16, and 19 showed neuroprotective activity. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/22607495/Diterpenoid_alkaloids_from_the_lateral_root_of_Aconitum_carmichaelii_ L2 - https://doi.org/10.1021/np300225t DB - PRIME DP - Unbound Medicine ER -