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Investigation of essential trace and toxic elements in biological samples (blood, serum and scalp hair) of liver cirrhotic/cancer female patients before and after mineral supplementation.
Clin Nutr 2012; 31(6):967-73CN

Abstract

BACKGROUND & AIMS

The aim of present study was to compare the levels of essential trace and toxic elements in biological samples (blood, serum and scalp hair) of female liver cirrhotic/cancer patients (n = 132), of two age groups (20-45 years) and (46-60 years), before and after sixty days treatment with mineral supplementation. For comparison purpose, same biological samples were also collected from healthy female subjects (n = 75) of same age groups.

METHODS

The biological samples were oxidized by 65% HNO(3): 30% H(2)O(2) (2:1) in microwave oven. The digests of all biological samples were analyzed for arsenic (As), cadmium (Cd), selenium (Se) and zinc (Zn) by electrothermal atomic absorption spectrometry.

RESULTS

The levels of Se and Zn were lower in liver cirrhotic/cancer patients as compared to healthy individuals (p < 0.001). The patients of liver cirrhosis/cancer have two folds higher As and Cd levels in biological samples as related to age matched referents. Moreover, negative correlation was observed between essential and toxic elements.

CONCLUSIONS

The pathogenesis of liver cirrhosis/cancer has been associated with changes in the balance of certain essential trace and toxic elements. It was observed that the status of Se and Zn in addition to some biochemical parameters was improved in biological samples of both groups of patients after sixty days treatment with mineral supplementation.

Authors+Show Affiliations

National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan. nidafatima6@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22607713

Citation

Kolachi, Nida Fatima, et al. "Investigation of Essential Trace and Toxic Elements in Biological Samples (blood, Serum and Scalp Hair) of Liver Cirrhotic/cancer Female Patients Before and After Mineral Supplementation." Clinical Nutrition (Edinburgh, Scotland), vol. 31, no. 6, 2012, pp. 967-73.
Kolachi NF, Kazi TG, Afridi HI, et al. Investigation of essential trace and toxic elements in biological samples (blood, serum and scalp hair) of liver cirrhotic/cancer female patients before and after mineral supplementation. Clin Nutr. 2012;31(6):967-73.
Kolachi, N. F., Kazi, T. G., Afridi, H. I., Kazi, N. G., & Khan, S. (2012). Investigation of essential trace and toxic elements in biological samples (blood, serum and scalp hair) of liver cirrhotic/cancer female patients before and after mineral supplementation. Clinical Nutrition (Edinburgh, Scotland), 31(6), pp. 967-73. doi:10.1016/j.clnu.2012.04.015.
Kolachi NF, et al. Investigation of Essential Trace and Toxic Elements in Biological Samples (blood, Serum and Scalp Hair) of Liver Cirrhotic/cancer Female Patients Before and After Mineral Supplementation. Clin Nutr. 2012;31(6):967-73. PubMed PMID: 22607713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of essential trace and toxic elements in biological samples (blood, serum and scalp hair) of liver cirrhotic/cancer female patients before and after mineral supplementation. AU - Kolachi,Nida Fatima, AU - Kazi,Tasneem Gul, AU - Afridi,Hassan Imran, AU - Kazi,Naveed Gul, AU - Khan,Sumaira, Y1 - 2012/05/17/ PY - 2011/10/14/received PY - 2012/04/19/revised PY - 2012/04/24/accepted PY - 2012/5/22/entrez PY - 2012/5/23/pubmed PY - 2013/5/10/medline SP - 967 EP - 73 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 31 IS - 6 N2 - BACKGROUND & AIMS: The aim of present study was to compare the levels of essential trace and toxic elements in biological samples (blood, serum and scalp hair) of female liver cirrhotic/cancer patients (n = 132), of two age groups (20-45 years) and (46-60 years), before and after sixty days treatment with mineral supplementation. For comparison purpose, same biological samples were also collected from healthy female subjects (n = 75) of same age groups. METHODS: The biological samples were oxidized by 65% HNO(3): 30% H(2)O(2) (2:1) in microwave oven. The digests of all biological samples were analyzed for arsenic (As), cadmium (Cd), selenium (Se) and zinc (Zn) by electrothermal atomic absorption spectrometry. RESULTS: The levels of Se and Zn were lower in liver cirrhotic/cancer patients as compared to healthy individuals (p < 0.001). The patients of liver cirrhosis/cancer have two folds higher As and Cd levels in biological samples as related to age matched referents. Moreover, negative correlation was observed between essential and toxic elements. CONCLUSIONS: The pathogenesis of liver cirrhosis/cancer has been associated with changes in the balance of certain essential trace and toxic elements. It was observed that the status of Se and Zn in addition to some biochemical parameters was improved in biological samples of both groups of patients after sixty days treatment with mineral supplementation. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/22607713/Investigation_of_essential_trace_and_toxic_elements_in_biological_samples__blood_serum_and_scalp_hair__of_liver_cirrhotic/cancer_female_patients_before_and_after_mineral_supplementation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(12)00087-8 DB - PRIME DP - Unbound Medicine ER -