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Adipose expression of adipocytokines in women with polycystic ovary syndrome.

Abstract

OBJECTIVE

To investigate the role of adipocytokines in the pathophysiology of polycystic ovary syndrome (PCOS) by analyzing the messenger RNA (mRNA) expression and plasma levels of adipocytokines.

DESIGN

Cross sectional study.

SETTING

Hospital.

PATIENT(S)

Thirty-six women with PCOS, 17 lean (LP) and 19 obese (OP), and 24 age- and weight-matched controls, 8 lean (LC) and 16 obese (OC).

INTERVENTION(S)

Subcutaneous adipose tissue and fasting plasma samples collected from 60 women, and insulin sensitivity evaluated by euglycemic hyperinsulinemic clamp and homeostatic model assessment insulin resistance index (HOMA-IR).

MAIN OUTCOME MEASURE(S)

mRNA expression of adiponectin, leptin, and interleukin-6 (IL-6) in adipose tissue, and plasma levels of leptin, adiponectin, resistin, visfatin, and tumor necrosis factor α (TNF-α).

RESULT(S)

The baseline data on body mass index (BMI), age, androgen levels, and insulin sensitivity was published previously. We found no independent effect of PCOS on the adipose expression of leptin, adiponectin, or IL-6 or on the plasma levels of adiponectin, leptin, resistin, visfatin, and TNF-α. Obesity was associated with increased mRNA expression of leptin, lower expression of adiponectin, and increased plasma levels of leptin.

CONCLUSION(S)

Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and marginally elevated expression of IL-6, but PCOS does not appear to have an independent effect on the adipose expression of leptin, adiponectin, and IL-6 or the circulating adipocytokines.

CLINICAL TRIAL REGISTRATION NUMBER

NCT00975832.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynaecology, Copenhagen University, Hvidovre, Denmark. pernillefsvendsen@hotmail.com

    , , , ,

    Source

    Fertility and sterility 98:1 2012 Jul pg 235-41

    MeSH

    Adipokines
    Adiponectin
    Adipose Tissue
    Adult
    Case-Control Studies
    Cross-Sectional Studies
    Cytokines
    Female
    Gene Expression
    Humans
    Interleukin-6
    Leptin
    Nicotinamide Phosphoribosyltransferase
    Obesity
    Polycystic Ovary Syndrome
    RNA, Messenger
    Resistin
    Thinness
    Tumor Necrosis Factor-alpha

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22607892

    Citation

    Svendsen, Pernille Fog, et al. "Adipose Expression of Adipocytokines in Women With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 98, no. 1, 2012, pp. 235-41.
    Svendsen PF, Christiansen M, Hedley PL, et al. Adipose expression of adipocytokines in women with polycystic ovary syndrome. Fertil Steril. 2012;98(1):235-41.
    Svendsen, P. F., Christiansen, M., Hedley, P. L., Nilas, L., Pedersen, S. B., & Madsbad, S. (2012). Adipose expression of adipocytokines in women with polycystic ovary syndrome. Fertility and Sterility, 98(1), pp. 235-41. doi:10.1016/j.fertnstert.2012.03.056.
    Svendsen PF, et al. Adipose Expression of Adipocytokines in Women With Polycystic Ovary Syndrome. Fertil Steril. 2012;98(1):235-41. PubMed PMID: 22607892.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adipose expression of adipocytokines in women with polycystic ovary syndrome. AU - Svendsen,Pernille Fog, AU - Christiansen,Michael, AU - Hedley,Paula Louise, AU - Nilas,Lisbeth, AU - Pedersen,Steen Bønløkke, AU - Madsbad,Sten, Y1 - 2012/05/16/ PY - 2011/09/18/received PY - 2012/03/26/revised PY - 2012/03/30/accepted PY - 2012/5/22/entrez PY - 2012/5/23/pubmed PY - 2012/9/6/medline SP - 235 EP - 41 JF - Fertility and sterility JO - Fertil. Steril. VL - 98 IS - 1 N2 - OBJECTIVE: To investigate the role of adipocytokines in the pathophysiology of polycystic ovary syndrome (PCOS) by analyzing the messenger RNA (mRNA) expression and plasma levels of adipocytokines. DESIGN: Cross sectional study. SETTING: Hospital. PATIENT(S): Thirty-six women with PCOS, 17 lean (LP) and 19 obese (OP), and 24 age- and weight-matched controls, 8 lean (LC) and 16 obese (OC). INTERVENTION(S): Subcutaneous adipose tissue and fasting plasma samples collected from 60 women, and insulin sensitivity evaluated by euglycemic hyperinsulinemic clamp and homeostatic model assessment insulin resistance index (HOMA-IR). MAIN OUTCOME MEASURE(S): mRNA expression of adiponectin, leptin, and interleukin-6 (IL-6) in adipose tissue, and plasma levels of leptin, adiponectin, resistin, visfatin, and tumor necrosis factor α (TNF-α). RESULT(S): The baseline data on body mass index (BMI), age, androgen levels, and insulin sensitivity was published previously. We found no independent effect of PCOS on the adipose expression of leptin, adiponectin, or IL-6 or on the plasma levels of adiponectin, leptin, resistin, visfatin, and TNF-α. Obesity was associated with increased mRNA expression of leptin, lower expression of adiponectin, and increased plasma levels of leptin. CONCLUSION(S): Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and marginally elevated expression of IL-6, but PCOS does not appear to have an independent effect on the adipose expression of leptin, adiponectin, and IL-6 or the circulating adipocytokines. CLINICAL TRIAL REGISTRATION NUMBER: NCT00975832. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/22607892/Adipose_expression_of_adipocytokines_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(12)00394-9 DB - PRIME DP - Unbound Medicine ER -