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Clinical significance of serum growth-regulated oncogene alpha (GROalpha) in patients with gynecological cancer.
PURPOSE OF INVESTIGATIONTo assess the clinical relevance of serum growth-regulated oncogene alpha (GROalpha) levels in gynecological cancer, we investigated its concentration in distinguishing patients with cervical cancer, endometrial cancer, ovarian cancer, benign ovarian tumor and control.
METHODSPreoperative serum GROalpha levels were measured in women with cervical cancer (n=46), endometrial cancer (n=39), ovarian cancer (n=124), benign ovarian tumors (n=52), and normal controls (n=38) using an enzyme-linked immunosorbent assay.
RESULTSStatistical analyses showed that the serum GROalpha concentration was significantly elevated in the cervical cancer, endometrial cancer and ovarian cancer patients compared with controls. Using GROalpha levels, the receiver operating characteristic (ROC) of cervical cancer (AUC approximately 0.775), endometrial cancer (AUC approximately 0.799), ovarian cancer (AUC approximately 0.749) and benign ovarian tumors (AUC approximately 0.568) vs. controls were identified.
CONCLUSIONOur findings suggest that serum GROalpha measurement as a molecular marker might contribute to detection and diagnosis of gynecological cancer.
Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medicine, Japan., , , ,
European journal of gynaecological oncology 33:2 2012 pg 138-41
MeSHAdenocarcinoma, Clear Cell
Area Under Curve
Enzyme-Linked Immunosorbent Assay
Tumor Markers, Biological
Uterine Cervical Neoplasms
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't