Tags

Type your tag names separated by a space and hit enter

Impulse oscillometry may be of value in detecting early manifestations of COPD.
Respir Med. 2012 Aug; 106(8):1116-23.RM

Abstract

BACKGROUND

Spirometry is used to diagnose chronic obstructive pulmonary disease (COPD). The Impulse oscillometry system (IOS) allows determination of respiratory impedance indices, which might be of potential value in early COPD, although previous experience is limited. We examined pulmonary resistance and reactance measured by IOS in subjects with or without self-reported chronic bronchitis or emphysema or COPD (Q+ or Q-) and subjects with or without COPD diagnosed according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria (G+ or G-).

METHODS

From a previous population-based study 450 subjects were examined with spirometry and IOS and answered a questionnaire on respiratory symptoms and diseases.

RESULTS

Seventy-seven subjects were Q+, of whom 34 also were G+. Q+/G- subjects (n = 43) reported respiratory symptoms more frequently (35-40% vs 8-14%) but had higher FEV(1) (100% vs 87%) than Q-/G+ subjects (n = 90), p < 0.05 for both comparisons. Q+ subjects had higher pulmonary resistance and lower pulmonary reactance than Q- subjects (p < 0.01 for all comparisons). The same pattern was seen both in G+ subjects ((Q+/Q-) R5 0.39/0.32, R5-R20 0.10/0.07, X5 0.13/0.09, AX 0.55/0.27, p < 0.05 for all) and G- subjects ((Q+/Q-) R5 0.35/0.29, R5-R20 0.08/0.06, X5 0.10/0.08, AX 0.31/0.19 p < 0.05 for all) except for R20 (adjusted for gender and age).

CONCLUSIONS

Self-reported chronic bronchitis or emphysema or COPD was associated with higher pulmonary resistance and lower pulmonary reactance measured by IOS, both among subjects with and without COPD according to GOLD criteria. IOS may have the potential to detect pathology associated with COPD earlier than spirometry.

Authors+Show Affiliations

Clinical Physiology and Nuclear Medicine Unit, Department of Clinical Sciences, Malmö, Lund University, Sweden. sophia.frantz@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22613172

Citation

Frantz, S, et al. "Impulse Oscillometry May Be of Value in Detecting Early Manifestations of COPD." Respiratory Medicine, vol. 106, no. 8, 2012, pp. 1116-23.
Frantz S, Nihlén U, Dencker M, et al. Impulse oscillometry may be of value in detecting early manifestations of COPD. Respir Med. 2012;106(8):1116-23.
Frantz, S., Nihlén, U., Dencker, M., Engström, G., Löfdahl, C. G., & Wollmer, P. (2012). Impulse oscillometry may be of value in detecting early manifestations of COPD. Respiratory Medicine, 106(8), 1116-23. https://doi.org/10.1016/j.rmed.2012.04.010
Frantz S, et al. Impulse Oscillometry May Be of Value in Detecting Early Manifestations of COPD. Respir Med. 2012;106(8):1116-23. PubMed PMID: 22613172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impulse oscillometry may be of value in detecting early manifestations of COPD. AU - Frantz,S, AU - Nihlén,U, AU - Dencker,M, AU - Engström,G, AU - Löfdahl,C G, AU - Wollmer,P, Y1 - 2012/05/20/ PY - 2011/12/16/received PY - 2012/04/26/revised PY - 2012/04/30/accepted PY - 2012/5/23/entrez PY - 2012/5/23/pubmed PY - 2012/9/7/medline SP - 1116 EP - 23 JF - Respiratory medicine JO - Respir Med VL - 106 IS - 8 N2 - BACKGROUND: Spirometry is used to diagnose chronic obstructive pulmonary disease (COPD). The Impulse oscillometry system (IOS) allows determination of respiratory impedance indices, which might be of potential value in early COPD, although previous experience is limited. We examined pulmonary resistance and reactance measured by IOS in subjects with or without self-reported chronic bronchitis or emphysema or COPD (Q+ or Q-) and subjects with or without COPD diagnosed according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria (G+ or G-). METHODS: From a previous population-based study 450 subjects were examined with spirometry and IOS and answered a questionnaire on respiratory symptoms and diseases. RESULTS: Seventy-seven subjects were Q+, of whom 34 also were G+. Q+/G- subjects (n = 43) reported respiratory symptoms more frequently (35-40% vs 8-14%) but had higher FEV(1) (100% vs 87%) than Q-/G+ subjects (n = 90), p < 0.05 for both comparisons. Q+ subjects had higher pulmonary resistance and lower pulmonary reactance than Q- subjects (p < 0.01 for all comparisons). The same pattern was seen both in G+ subjects ((Q+/Q-) R5 0.39/0.32, R5-R20 0.10/0.07, X5 0.13/0.09, AX 0.55/0.27, p < 0.05 for all) and G- subjects ((Q+/Q-) R5 0.35/0.29, R5-R20 0.08/0.06, X5 0.10/0.08, AX 0.31/0.19 p < 0.05 for all) except for R20 (adjusted for gender and age). CONCLUSIONS: Self-reported chronic bronchitis or emphysema or COPD was associated with higher pulmonary resistance and lower pulmonary reactance measured by IOS, both among subjects with and without COPD according to GOLD criteria. IOS may have the potential to detect pathology associated with COPD earlier than spirometry. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/22613172/Impulse_oscillometry_may_be_of_value_in_detecting_early_manifestations_of_COPD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(12)00182-5 DB - PRIME DP - Unbound Medicine ER -