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Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett.
Molecules. 2012 May 21; 17(5):6071-82.M

Abstract

One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid.

Authors+Show Affiliations

Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22614861

Citation

Hashim, Najihah Mohd, et al. "Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Xanthones Isolated From Artocarpus Obtusus F.M. Jarrett." Molecules (Basel, Switzerland), vol. 17, no. 5, 2012, pp. 6071-82.
Hashim NM, Rahmani M, Ee GC, et al. Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett. Molecules. 2012;17(5):6071-82.
Hashim, N. M., Rahmani, M., Ee, G. C., Sukari, M. A., Yahayu, M., Amin, M. A., Ali, A. M., & Go, R. (2012). Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett. Molecules (Basel, Switzerland), 17(5), 6071-82. https://doi.org/10.3390/molecules17056071
Hashim NM, et al. Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Xanthones Isolated From Artocarpus Obtusus F.M. Jarrett. Molecules. 2012 May 21;17(5):6071-82. PubMed PMID: 22614861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett. AU - Hashim,Najihah Mohd, AU - Rahmani,Mawardi, AU - Ee,Gwendoline Cheng Lian, AU - Sukari,Mohd Aspollah, AU - Yahayu,Maizatulakmal, AU - Amin,Muhamad Aizat Mohd, AU - Ali,Abd Manaf, AU - Go,Rusea, Y1 - 2012/05/21/ PY - 2012/03/05/received PY - 2012/04/17/revised PY - 2012/04/20/accepted PY - 2012/5/23/entrez PY - 2012/5/23/pubmed PY - 2012/9/22/medline SP - 6071 EP - 82 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 17 IS - 5 N2 - One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/22614861/Antioxidant_antimicrobial_and_tyrosinase_inhibitory_activities_of_xanthones_isolated_from_Artocarpus_obtusus_F_M__Jarrett_ L2 - https://www.mdpi.com/resolver?pii=molecules17056071 DB - PRIME DP - Unbound Medicine ER -