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Corneal melting two weeks after pterygium excision with topical mitomycin C: successfully treated with lamellar keratoplasty and amnion membrane transplantation.
Case Rep Ophthalmol. 2012 Jan; 3(1):24-9.CR

Abstract

PURPOSE

To report the management of a case of corneal melting two weeks after pterygium excision with intraoperative topical mitomycin C (MMC).

METHODS

Case report.

RESULTS

A 57-year-old male was referred to our Department for therapy of rapidly progressive corneal melting two weeks after primary pterygium surgery with MMC (0.2 mg/ml) in September 2009. Initial treatment consisted of topical and systemic immunosuppression along with topical antibiotics. Eight days after presentation, the patient underwent successful lamellar keratoplasty and amnion membrane transplantation. Subconjunctival injection of triamcinolone (40 mg/ml) and topical bevacizumab were used to manage the increased fibrovascular activity around the site of the former pterygium.

CONCLUSION

Topical use of MMC during pterygium surgery may be related to serious postoperative complications such as progressive inflammatory corneal melting. The etiology may be multifactorial, which is related to MMC-induced inflammation and/or induced apoptosis. A therapeutic option is the described combination of systemic and local anti-inflammatory treatment along with lamellar keratoplasty and amniotic membrane transplantation. Adjunctive therapy may be needed if recurrence occurs.

Authors+Show Affiliations

Department of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports

Language

eng

PubMed ID

22615697

Citation

Menghini, Moreno, et al. "Corneal Melting Two Weeks After Pterygium Excision With Topical Mitomycin C: Successfully Treated With Lamellar Keratoplasty and Amnion Membrane Transplantation." Case Reports in Ophthalmology, vol. 3, no. 1, 2012, pp. 24-9.
Menghini M, Watson SL, Bosch MM. Corneal melting two weeks after pterygium excision with topical mitomycin C: successfully treated with lamellar keratoplasty and amnion membrane transplantation. Case Rep Ophthalmol. 2012;3(1):24-9.
Menghini, M., Watson, S. L., & Bosch, M. M. (2012). Corneal melting two weeks after pterygium excision with topical mitomycin C: successfully treated with lamellar keratoplasty and amnion membrane transplantation. Case Reports in Ophthalmology, 3(1), 24-9. https://doi.org/10.1159/000336452
Menghini M, Watson SL, Bosch MM. Corneal Melting Two Weeks After Pterygium Excision With Topical Mitomycin C: Successfully Treated With Lamellar Keratoplasty and Amnion Membrane Transplantation. Case Rep Ophthalmol. 2012;3(1):24-9. PubMed PMID: 22615697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corneal melting two weeks after pterygium excision with topical mitomycin C: successfully treated with lamellar keratoplasty and amnion membrane transplantation. AU - Menghini,Moreno, AU - Watson,Stephanie L, AU - Bosch,Martina M, Y1 - 2012/01/31/ PY - 2012/5/23/entrez PY - 2012/5/23/pubmed PY - 2012/5/23/medline KW - Amniotic membrane KW - Corneal melting KW - Lamellar keratoplasty KW - Mitomycin C KW - Pterygium SP - 24 EP - 9 JF - Case reports in ophthalmology JO - Case Rep Ophthalmol VL - 3 IS - 1 N2 - PURPOSE: To report the management of a case of corneal melting two weeks after pterygium excision with intraoperative topical mitomycin C (MMC). METHODS: Case report. RESULTS: A 57-year-old male was referred to our Department for therapy of rapidly progressive corneal melting two weeks after primary pterygium surgery with MMC (0.2 mg/ml) in September 2009. Initial treatment consisted of topical and systemic immunosuppression along with topical antibiotics. Eight days after presentation, the patient underwent successful lamellar keratoplasty and amnion membrane transplantation. Subconjunctival injection of triamcinolone (40 mg/ml) and topical bevacizumab were used to manage the increased fibrovascular activity around the site of the former pterygium. CONCLUSION: Topical use of MMC during pterygium surgery may be related to serious postoperative complications such as progressive inflammatory corneal melting. The etiology may be multifactorial, which is related to MMC-induced inflammation and/or induced apoptosis. A therapeutic option is the described combination of systemic and local anti-inflammatory treatment along with lamellar keratoplasty and amniotic membrane transplantation. Adjunctive therapy may be needed if recurrence occurs. SN - 1663-2699 UR - https://www.unboundmedicine.com/medline/citation/22615697/Corneal_melting_two_weeks_after_pterygium_excision_with_topical_mitomycin_C:_successfully_treated_with_lamellar_keratoplasty_and_amnion_membrane_transplantation L2 - https://www.karger.com?DOI=10.1159/000336452 DB - PRIME DP - Unbound Medicine ER -
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