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A cohort study of serum bilirubin levels and incident non-alcoholic fatty liver disease in middle aged Korean workers.
PLoS One. 2012; 7(5):e37241.Plos

Abstract

BACKGROUND

Serum bilirubin may have potent antioxidant and cytoprotective effects. Serum bilirubin levels are inversely associated with several cardiovascular and metabolic endpoints, but their association with nonalcoholic fatty liver disease (NAFLD) has not been investigated except for a single cross-sectional study in a pediatric population. We assessed the prospective association between serum bilirubin concentrations (total, direct, and indirect) and the risk for NAFLD.

METHODS AND FINDINGS

We performed a cohort study in 5,900 Korean men, 30 to 59 years of age, with no evidence of liver disease and no major risk factors for liver disease at baseline. Study participants were followed in annual or biennial health examinations between 2002 and 2009. The presence of fatty liver was determined at each visit by ultrasonography. We observed 1,938 incident cases of NAFLD during 28,101.8 person-years of follow-up. Increasing levels of serum direct bilirubin were progressively associated with a decreasing incidence of NAFLD. In age-adjusted models, the hazard ratio for NAFLD comparing the highest to the lowest quartile of serum direct bilirubin levels was 0.61 (95% CI 0.54-0.68). The association persisted after adjusting for multiple metabolic parameters (hazard ratio comparing the highest to the lowest quartile 0.86, 95% CI 0.76-0.98; P trend = 0.039). Neither serum total nor indirect bilirubin levels were significantly associated with the incidence of NAFLD.

CONCLUSIONS

In this large prospective study, higher serum direct bilirubin levels were significantly associated with a lower risk of developing NAFLD, even adjusting for a variety of metabolic parameters. Further research is needed to elucidate the mechanisms underlying this association and to establish the role of serum direct bilirubin as a marker for NAFLD risk.

Authors+Show Affiliations

Department of Occupational Medicine, Kangbuk Samsung Hospital and Sungkyunkwan University School of Medicine, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22615952

Citation

Chang, Yoosoo, et al. "A Cohort Study of Serum Bilirubin Levels and Incident Non-alcoholic Fatty Liver Disease in Middle Aged Korean Workers." PloS One, vol. 7, no. 5, 2012, pp. e37241.
Chang Y, Ryu S, Zhang Y, et al. A cohort study of serum bilirubin levels and incident non-alcoholic fatty liver disease in middle aged Korean workers. PLoS One. 2012;7(5):e37241.
Chang, Y., Ryu, S., Zhang, Y., Son, H. J., Kim, J. Y., Cho, J., & Guallar, E. (2012). A cohort study of serum bilirubin levels and incident non-alcoholic fatty liver disease in middle aged Korean workers. PloS One, 7(5), e37241. https://doi.org/10.1371/journal.pone.0037241
Chang Y, et al. A Cohort Study of Serum Bilirubin Levels and Incident Non-alcoholic Fatty Liver Disease in Middle Aged Korean Workers. PLoS One. 2012;7(5):e37241. PubMed PMID: 22615952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cohort study of serum bilirubin levels and incident non-alcoholic fatty liver disease in middle aged Korean workers. AU - Chang,Yoosoo, AU - Ryu,Seungho, AU - Zhang,Yiyi, AU - Son,Hee Jung, AU - Kim,Jang-Young, AU - Cho,Juhee, AU - Guallar,Eliseo, Y1 - 2012/05/15/ PY - 2011/12/26/received PY - 2012/04/18/accepted PY - 2012/5/23/entrez PY - 2012/5/23/pubmed PY - 2012/9/21/medline SP - e37241 EP - e37241 JF - PloS one JO - PLoS One VL - 7 IS - 5 N2 - BACKGROUND: Serum bilirubin may have potent antioxidant and cytoprotective effects. Serum bilirubin levels are inversely associated with several cardiovascular and metabolic endpoints, but their association with nonalcoholic fatty liver disease (NAFLD) has not been investigated except for a single cross-sectional study in a pediatric population. We assessed the prospective association between serum bilirubin concentrations (total, direct, and indirect) and the risk for NAFLD. METHODS AND FINDINGS: We performed a cohort study in 5,900 Korean men, 30 to 59 years of age, with no evidence of liver disease and no major risk factors for liver disease at baseline. Study participants were followed in annual or biennial health examinations between 2002 and 2009. The presence of fatty liver was determined at each visit by ultrasonography. We observed 1,938 incident cases of NAFLD during 28,101.8 person-years of follow-up. Increasing levels of serum direct bilirubin were progressively associated with a decreasing incidence of NAFLD. In age-adjusted models, the hazard ratio for NAFLD comparing the highest to the lowest quartile of serum direct bilirubin levels was 0.61 (95% CI 0.54-0.68). The association persisted after adjusting for multiple metabolic parameters (hazard ratio comparing the highest to the lowest quartile 0.86, 95% CI 0.76-0.98; P trend = 0.039). Neither serum total nor indirect bilirubin levels were significantly associated with the incidence of NAFLD. CONCLUSIONS: In this large prospective study, higher serum direct bilirubin levels were significantly associated with a lower risk of developing NAFLD, even adjusting for a variety of metabolic parameters. Further research is needed to elucidate the mechanisms underlying this association and to establish the role of serum direct bilirubin as a marker for NAFLD risk. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22615952/A_cohort_study_of_serum_bilirubin_levels_and_incident_non_alcoholic_fatty_liver_disease_in_middle_aged_Korean_workers_ L2 - https://dx.plos.org/10.1371/journal.pone.0037241 DB - PRIME DP - Unbound Medicine ER -