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Puberunine and puberudine, two new C18-diterpenoid alkaloids from Aconitum barbatum var. puberulum.
Org Lett. 2012 Jun 01; 14(11):2758-61.OL

Abstract

Two C(18)-diterpenoid alkaloids, puberunine (1) and puberudine (2), together with four other new alkaloids, including the first examples having β-oriented substitution at C-3 and a rare chloro-substituent were isolated from Aconitum barbatum var. puberulum. Their structures were elucidated by spectroscopic methods. Puberunine and puberudine, which possess a unique rearranged E ring and an opened A ring, respectively, represent new subtypes of the C(18)-diterpenoid alkaloids. A plausible biosynthetic pathway of 1 and 2 was proposed.

Authors+Show Affiliations

College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22616819

Citation

Mu, Zhen-Qiang, et al. "Puberunine and Puberudine, Two New C18-diterpenoid Alkaloids From Aconitum Barbatum Var. Puberulum." Organic Letters, vol. 14, no. 11, 2012, pp. 2758-61.
Mu ZQ, Gao H, Huang ZY, et al. Puberunine and puberudine, two new C18-diterpenoid alkaloids from Aconitum barbatum var. puberulum. Org Lett. 2012;14(11):2758-61.
Mu, Z. Q., Gao, H., Huang, Z. Y., Feng, X. L., & Yao, X. S. (2012). Puberunine and puberudine, two new C18-diterpenoid alkaloids from Aconitum barbatum var. puberulum. Organic Letters, 14(11), 2758-61. https://doi.org/10.1021/ol3008217
Mu ZQ, et al. Puberunine and Puberudine, Two New C18-diterpenoid Alkaloids From Aconitum Barbatum Var. Puberulum. Org Lett. 2012 Jun 1;14(11):2758-61. PubMed PMID: 22616819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Puberunine and puberudine, two new C18-diterpenoid alkaloids from Aconitum barbatum var. puberulum. AU - Mu,Zhen-Qiang, AU - Gao,Hao, AU - Huang,Zhi-Yun, AU - Feng,Xiao-Lin, AU - Yao,Xin-Sheng, Y1 - 2012/05/22/ PY - 2012/5/24/entrez PY - 2012/5/24/pubmed PY - 2012/9/6/medline SP - 2758 EP - 61 JF - Organic letters JO - Org Lett VL - 14 IS - 11 N2 - Two C(18)-diterpenoid alkaloids, puberunine (1) and puberudine (2), together with four other new alkaloids, including the first examples having β-oriented substitution at C-3 and a rare chloro-substituent were isolated from Aconitum barbatum var. puberulum. Their structures were elucidated by spectroscopic methods. Puberunine and puberudine, which possess a unique rearranged E ring and an opened A ring, respectively, represent new subtypes of the C(18)-diterpenoid alkaloids. A plausible biosynthetic pathway of 1 and 2 was proposed. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/22616819/Puberunine_and_puberudine_two_new_C18_diterpenoid_alkaloids_from_Aconitum_barbatum_var__puberulum_ L2 - https://doi.org/10.1021/ol3008217 DB - PRIME DP - Unbound Medicine ER -