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Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study.
Eur J Clin Nutr 2012; 66(8):950-6EJ

Abstract

BACKGROUND/OBJECTIVES

Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study.

SUBJECTS/METHODS

Participants were 306,331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall.

RESULTS

After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07).

CONCLUSION

A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.

Authors+Show Affiliations

Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. francesca.crowe@ceu.ox.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22617277

Citation

Crowe, F L., et al. "Dietary Fibre Intake and Ischaemic Heart Disease Mortality: the European Prospective Investigation Into Cancer and Nutrition-Heart Study." European Journal of Clinical Nutrition, vol. 66, no. 8, 2012, pp. 950-6.
Crowe FL, Key TJ, Appleby PN, et al. Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study. Eur J Clin Nutr. 2012;66(8):950-6.
Crowe, F. L., Key, T. J., Appleby, P. N., Overvad, K., Schmidt, E. B., Egeberg, R., ... Riboli, E. (2012). Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study. European Journal of Clinical Nutrition, 66(8), pp. 950-6. doi:10.1038/ejcn.2012.51.
Crowe FL, et al. Dietary Fibre Intake and Ischaemic Heart Disease Mortality: the European Prospective Investigation Into Cancer and Nutrition-Heart Study. Eur J Clin Nutr. 2012;66(8):950-6. PubMed PMID: 22617277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study. AU - Crowe,F L, AU - Key,T J, AU - Appleby,P N, AU - Overvad,K, AU - Schmidt,E B, AU - Egeberg,R, AU - Tjønneland,A, AU - Kaaks,R, AU - Teucher,B, AU - Boeing,H, AU - Weikert,C, AU - Trichopoulou,A, AU - Ouranos,V, AU - Valanou,E, AU - Masala,G, AU - Sieri,S, AU - Panico,S, AU - Tumino,R, AU - Matullo,G, AU - Bueno-de-Mesquita,H B, AU - Boer,J M A, AU - Beulens,J W J, AU - van der Schouw,Y T, AU - Quirós,J R, AU - Buckland,G, AU - Sánchez,M-J, AU - Dorronsoro,M, AU - Huerta,J M, AU - Moreno-Iribas,C, AU - Hedblad,B, AU - Jansson,J H, AU - Wennberg,P, AU - Khaw,K-T, AU - Wareham,N, AU - Ferrari,P, AU - Illner,A-K, AU - Chuang,S-C, AU - Norat,T, AU - Danesh,J, AU - Riboli,E, Y1 - 2012/05/23/ PY - 2012/5/24/entrez PY - 2012/5/24/pubmed PY - 2012/12/12/medline SP - 950 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 8 N2 - BACKGROUND/OBJECTIVES: Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study. SUBJECTS/METHODS: Participants were 306,331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall. RESULTS: After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07). CONCLUSION: A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/22617277/Dietary_fibre_intake_and_ischaemic_heart_disease_mortality:_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_Heart_study_ L2 - http://dx.doi.org/10.1038/ejcn.2012.51 DB - PRIME DP - Unbound Medicine ER -