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Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women.
J Nutr Biochem. 2012 Dec; 23(12):1725-31.JN

Abstract

Increased plasma total antioxidant capacity (TAC) has been associated with a high consumption of fruits and vegetables. However, limited information is available on whether plasma TAC reflects the dietary intake of antioxidants and the levels of individual antioxidants in plasma. By using three different assays, the study aimed to determine if plasma TAC can effectively predict dietary intake of antioxidants and plasma antioxidant status. Forty overweight and apparently healthy postmenopausal women were recruited. Seven-day food records and 12-h fasting blood samples were collected for dietary and plasma antioxidant assessments. Plasma TAC was determined by vitamin C equivalent antioxidant capacity (VCEAC), ferric-reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) assays. TAC values determined by VCEAC were highly correlated with FRAP (r=0.79, P<.01) and moderately correlated with ORAC (r=0.34, P<.05). Pearson correlation analyses showed that plasma TAC values by VCEAC and ORAC had positive correlation with plasma uric acid (r=0.56 for VCEAC; r=0.49 for ORAC) and total phenolics (r=0.63 for VCEAC; r=0.36 for ORAC). However, TAC measured by FRAP was correlated only with uric acid (r=0.69). After multivariate adjustment, plasma TAC determined by VCEAC was positively associated with dietary intakes of γ-tocopherol (P<.001), β-carotene (P<.05), anthocyanidins (P<.05), flavones (P<.05), proanthocyanidins (P<.01) and TAC (P<.05), as well as with plasma total phenolics (P<.05), α-tocopherol (P<.001), β-cryptoxanthin (P<.05) and uric acid (P<.05). The findings indicate that plasma TAC measured by VCEAC reflects both dietary and plasma antioxidants and represents more closely the plasma antioxidant levels than ORAC and FRAP.

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Publisher Full Text

Authors+Show Affiliations

Wang Y
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USA.
Yang M
No affiliation info available
Lee SG
No affiliation info available
Davis CG
No affiliation info available
Kenny A
No affiliation info available
Koo SI
No affiliation info available
Chun OK
No affiliation info available

MeSH

AdultAgedAnthocyaninsAntioxidantsBlood Chemical AnalysisCross-Sectional StudiesCryptoxanthinsDietDietary SupplementsFemaleFlavonesHumansMiddle AgedMultivariate AnalysisObesityOverweightPostmenopauseUric AcidXanthophyllsbeta Carotenegamma-Tocopherol

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22617460

Citation

Wang, Ying, et al. "Plasma Total Antioxidant Capacity Is Associated With Dietary Intake and Plasma Level of Antioxidants in Postmenopausal Women." The Journal of Nutritional Biochemistry, vol. 23, no. 12, 2012, pp. 1725-31.
Wang Y, Yang M, Lee SG, et al. Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women. J Nutr Biochem. 2012;23(12):1725-31.
Wang, Y., Yang, M., Lee, S. G., Davis, C. G., Kenny, A., Koo, S. I., & Chun, O. K. (2012). Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women. The Journal of Nutritional Biochemistry, 23(12), 1725-31. https://doi.org/10.1016/j.jnutbio.2011.12.004
Wang Y, et al. Plasma Total Antioxidant Capacity Is Associated With Dietary Intake and Plasma Level of Antioxidants in Postmenopausal Women. J Nutr Biochem. 2012;23(12):1725-31. PubMed PMID: 22617460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women. AU - Wang,Ying, AU - Yang,Meng, AU - Lee,Sang-Gil, AU - Davis,Catherine G, AU - Kenny,Anne, AU - Koo,Sung I, AU - Chun,Ock K, Y1 - 2012/05/21/ PY - 2011/08/13/received PY - 2011/11/07/revised PY - 2011/12/19/accepted PY - 2012/5/24/entrez PY - 2012/5/24/pubmed PY - 2013/5/1/medline SP - 1725 EP - 31 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 23 IS - 12 N2 - Increased plasma total antioxidant capacity (TAC) has been associated with a high consumption of fruits and vegetables. However, limited information is available on whether plasma TAC reflects the dietary intake of antioxidants and the levels of individual antioxidants in plasma. By using three different assays, the study aimed to determine if plasma TAC can effectively predict dietary intake of antioxidants and plasma antioxidant status. Forty overweight and apparently healthy postmenopausal women were recruited. Seven-day food records and 12-h fasting blood samples were collected for dietary and plasma antioxidant assessments. Plasma TAC was determined by vitamin C equivalent antioxidant capacity (VCEAC), ferric-reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) assays. TAC values determined by VCEAC were highly correlated with FRAP (r=0.79, P<.01) and moderately correlated with ORAC (r=0.34, P<.05). Pearson correlation analyses showed that plasma TAC values by VCEAC and ORAC had positive correlation with plasma uric acid (r=0.56 for VCEAC; r=0.49 for ORAC) and total phenolics (r=0.63 for VCEAC; r=0.36 for ORAC). However, TAC measured by FRAP was correlated only with uric acid (r=0.69). After multivariate adjustment, plasma TAC determined by VCEAC was positively associated with dietary intakes of γ-tocopherol (P<.001), β-carotene (P<.05), anthocyanidins (P<.05), flavones (P<.05), proanthocyanidins (P<.01) and TAC (P<.05), as well as with plasma total phenolics (P<.05), α-tocopherol (P<.001), β-cryptoxanthin (P<.05) and uric acid (P<.05). The findings indicate that plasma TAC measured by VCEAC reflects both dietary and plasma antioxidants and represents more closely the plasma antioxidant levels than ORAC and FRAP. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/22617460/Plasma_total_antioxidant_capacity_is_associated_with_dietary_intake_and_plasma_level_of_antioxidants_in_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(12)00019-8 DB - PRIME DP - Unbound Medicine ER -