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Epstein-Barr virus cause of multiple sclerosis.
Curr Opin Rheumatol 2012; 24(4):424-8CO

Abstract

PURPOSE OF REVIEW

The cause of multiple sclerosis (MS) has eluded medical science for over a century. Pierre Marie speculated that MS is an infectious disease and this paradigm has had a prominent place in the discussion. A number of candidate pathogens have been proposed, but most have not survived scrutiny. In this review, we summarize the evidence that MS is caused by Epstein-Barr virus (EBV), which has been a prominent candidate for several decades. Although there is much suggestive evidence that EBV is involved in the pathogenesis of MS, the precise effect of EBV is still unclear.

RECENT FINDINGS

EBV is more common in MS patients than in controls. A history of infectious mononucleosis, and high baseline EBV antibody titers are risk factors for MS. More controversial are findings of changes in the reactivity of the T-cell repertoire, presence of EBV antibodies in the cerebrospinal fluid, and presence of EBV in meningeal lymphoid follicles and perivenular infiltrates in the white matter.

SUMMARY

The contribution of EBV to the cause of MS is not yet established, but a relationship is clearly present.

Authors+Show Affiliations

Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA. atselis@med.wayne.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22617821

Citation

Tselis, Alex. "Epstein-Barr Virus Cause of Multiple Sclerosis." Current Opinion in Rheumatology, vol. 24, no. 4, 2012, pp. 424-8.
Tselis A. Epstein-Barr virus cause of multiple sclerosis. Curr Opin Rheumatol. 2012;24(4):424-8.
Tselis, A. (2012). Epstein-Barr virus cause of multiple sclerosis. Current Opinion in Rheumatology, 24(4), pp. 424-8. doi:10.1097/BOR.0b013e3283542cf8.
Tselis A. Epstein-Barr Virus Cause of Multiple Sclerosis. Curr Opin Rheumatol. 2012;24(4):424-8. PubMed PMID: 22617821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epstein-Barr virus cause of multiple sclerosis. A1 - Tselis,Alex, PY - 2012/5/24/entrez PY - 2012/5/24/pubmed PY - 2012/9/7/medline SP - 424 EP - 8 JF - Current opinion in rheumatology JO - Curr Opin Rheumatol VL - 24 IS - 4 N2 - PURPOSE OF REVIEW: The cause of multiple sclerosis (MS) has eluded medical science for over a century. Pierre Marie speculated that MS is an infectious disease and this paradigm has had a prominent place in the discussion. A number of candidate pathogens have been proposed, but most have not survived scrutiny. In this review, we summarize the evidence that MS is caused by Epstein-Barr virus (EBV), which has been a prominent candidate for several decades. Although there is much suggestive evidence that EBV is involved in the pathogenesis of MS, the precise effect of EBV is still unclear. RECENT FINDINGS: EBV is more common in MS patients than in controls. A history of infectious mononucleosis, and high baseline EBV antibody titers are risk factors for MS. More controversial are findings of changes in the reactivity of the T-cell repertoire, presence of EBV antibodies in the cerebrospinal fluid, and presence of EBV in meningeal lymphoid follicles and perivenular infiltrates in the white matter. SUMMARY: The contribution of EBV to the cause of MS is not yet established, but a relationship is clearly present. SN - 1531-6963 UR - https://www.unboundmedicine.com/medline/citation/22617821/Epstein_Barr_virus_cause_of_multiple_sclerosis_ L2 - http://Insights.ovid.com/pubmed?pmid=22617821 DB - PRIME DP - Unbound Medicine ER -