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Geranyl flavonoid derivatives from the fresh leaves of Artocarpus communis and their anti-inflammatory activity.
Planta Med. 2012 Jun; 78(10):995-1001.PM

Abstract

Breadfruit (Artocarpus communis) is a widely distributed crop in tropical and subtropical regions of the world. It is used in Southeast Asia and India to treat several inflammatory disorders. The aim of this study was to investigate the presence of anti-inflammatory flavonoids in A. communis leaves. Three new geranyl flavonoids, arcommunol C (1), arcommunol D (3), and 5'-geranyl-3,4,2',4'-tetrahydroxychalcone (5), together with four known compounds, prostratol (2), arcommunol E (4), 3'-geranyl-3,4,2',4'-tetrahydroxydihydrochalcone (6), and 3'-geranyl-3,4,2',4'-tetrahydroxychalcone (7), were isolated from the leaves of A. communis. Compound 4 was isolated for the first time from natural sources. The anti-inflammatory activity of the isolated compounds (1-7) was evaluated by determining their inhibitory activity on the production of proinflammatory mediators in lipopolysaccharide (LPS)-activated RAW 264.7 murine macrophage cells. Compounds 2, 3, and 4 suppressed the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC50 values of 8.13 ± 0.17, 18.45 ± 2.15, and 22.74 ± 1.74 µM, respectively. Furthermore, 2 decreased lipopolysaccharide (LPS)-mediated induction of protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells. It was also found that 2 suppressed LPS-induced phosphorylation of JNK and p38 mitogen-activated protein kinase (MAPK) signaling.

Authors+Show Affiliations

School of Nutrition, Chung Shan Medical University and Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22618373

Citation

Hsu, Chin-Lin, et al. "Geranyl Flavonoid Derivatives From the Fresh Leaves of Artocarpus Communis and Their Anti-inflammatory Activity." Planta Medica, vol. 78, no. 10, 2012, pp. 995-1001.
Hsu CL, Chang FR, Tseng PY, et al. Geranyl flavonoid derivatives from the fresh leaves of Artocarpus communis and their anti-inflammatory activity. Planta Med. 2012;78(10):995-1001.
Hsu, C. L., Chang, F. R., Tseng, P. Y., Chen, Y. F., El-Shazly, M., Du, Y. C., & Fang, S. C. (2012). Geranyl flavonoid derivatives from the fresh leaves of Artocarpus communis and their anti-inflammatory activity. Planta Medica, 78(10), 995-1001. https://doi.org/10.1055/s-0031-1298580
Hsu CL, et al. Geranyl Flavonoid Derivatives From the Fresh Leaves of Artocarpus Communis and Their Anti-inflammatory Activity. Planta Med. 2012;78(10):995-1001. PubMed PMID: 22618373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Geranyl flavonoid derivatives from the fresh leaves of Artocarpus communis and their anti-inflammatory activity. AU - Hsu,Chin-Lin, AU - Chang,Fang-Rong, AU - Tseng,Pei-Yu, AU - Chen,Yi-Fen, AU - El-Shazly,Mohamed, AU - Du,Ying-Chi, AU - Fang,Song-Chwan, Y1 - 2012/05/22/ PY - 2012/5/24/entrez PY - 2012/5/24/pubmed PY - 2012/11/1/medline SP - 995 EP - 1001 JF - Planta medica JO - Planta Med VL - 78 IS - 10 N2 - Breadfruit (Artocarpus communis) is a widely distributed crop in tropical and subtropical regions of the world. It is used in Southeast Asia and India to treat several inflammatory disorders. The aim of this study was to investigate the presence of anti-inflammatory flavonoids in A. communis leaves. Three new geranyl flavonoids, arcommunol C (1), arcommunol D (3), and 5'-geranyl-3,4,2',4'-tetrahydroxychalcone (5), together with four known compounds, prostratol (2), arcommunol E (4), 3'-geranyl-3,4,2',4'-tetrahydroxydihydrochalcone (6), and 3'-geranyl-3,4,2',4'-tetrahydroxychalcone (7), were isolated from the leaves of A. communis. Compound 4 was isolated for the first time from natural sources. The anti-inflammatory activity of the isolated compounds (1-7) was evaluated by determining their inhibitory activity on the production of proinflammatory mediators in lipopolysaccharide (LPS)-activated RAW 264.7 murine macrophage cells. Compounds 2, 3, and 4 suppressed the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC50 values of 8.13 ± 0.17, 18.45 ± 2.15, and 22.74 ± 1.74 µM, respectively. Furthermore, 2 decreased lipopolysaccharide (LPS)-mediated induction of protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells. It was also found that 2 suppressed LPS-induced phosphorylation of JNK and p38 mitogen-activated protein kinase (MAPK) signaling. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/22618373/Geranyl_flavonoid_derivatives_from_the_fresh_leaves_of_Artocarpus_communis_and_their_anti_inflammatory_activity_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1298580 DB - PRIME DP - Unbound Medicine ER -