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Anti-inflammatory sesquiterpene lactones from Lychnophora trichocarpha Spreng. (Brazilian Arnica).
Phytother Res. 2013 Mar; 27(3):384-9.PR

Abstract

The aerial parts of Lychnophora trichocarpha Spreng. (Asteraceae) are used macerated in water or ethanol to treat inflammation, pain, rheumatism, contusions, bruises and insect bites in Brazilian traditional medicine. In this study, anti-inflammatory activity of ethanol extract from aerial parts of L. trichocarpha and its ethyl acetate fraction was investigated. Sesquiterpene lactones, lychnopholide (Lyc) and eremantholide C (EreC), isolated of ethyl acetate fraction, were also assayed for in vitro and in vivo anti-inflammatory activity. Topical treatment with ointments containing ethanol extract, its ethyl acetate fraction and sesquiterpene lactones significantly reduced carrageenan-induced mice paw oedema. In vitro assays demonstrated that Lyc inhibited interferon -γ/lipopolysaccharide -stimulated nitric oxide (NO) production in J774A.1 macrophages and increased production of IL-10 anti-inflammatory cytokine. The reduction of tumor necrosis factor-α (TNF-α) production by EreC was accompanied by an increased production of IL-10 in a concentration-dependent manner in J774A.1 macrophages. The anti-inflammatory effect of Lyc seems to involve the inhibition of production of NO and increased production of IL-10. The mechanism of the effect of EreC on the reduction of carrageenan-induced paw oedema may be attributed to inhibition of production of TNF-α and stimulation of IL-10 production. The results corroborate the use of ethanol extract from Lychnophora trichocarpha in folk medicine for anti-inflammatory action and indicate that the topical route is suitable for use.

Authors+Show Affiliations

Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22619042

Citation

Ferrari, Fernanda C., et al. "Anti-inflammatory Sesquiterpene Lactones From Lychnophora Trichocarpha Spreng. (Brazilian Arnica)." Phytotherapy Research : PTR, vol. 27, no. 3, 2013, pp. 384-9.
Ferrari FC, Ferreira LC, Souza MR, et al. Anti-inflammatory sesquiterpene lactones from Lychnophora trichocarpha Spreng. (Brazilian Arnica). Phytother Res. 2013;27(3):384-9.
Ferrari, F. C., Ferreira, L. C., Souza, M. R., Grabe-Guimarães, A., Paula, C. A., Rezende, S. A., & Saúde-Guimarães, D. A. (2013). Anti-inflammatory sesquiterpene lactones from Lychnophora trichocarpha Spreng. (Brazilian Arnica). Phytotherapy Research : PTR, 27(3), 384-9. https://doi.org/10.1002/ptr.4736
Ferrari FC, et al. Anti-inflammatory Sesquiterpene Lactones From Lychnophora Trichocarpha Spreng. (Brazilian Arnica). Phytother Res. 2013;27(3):384-9. PubMed PMID: 22619042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory sesquiterpene lactones from Lychnophora trichocarpha Spreng. (Brazilian Arnica). AU - Ferrari,Fernanda C, AU - Ferreira,Leidiane C, AU - Souza,Maíra R, AU - Grabe-Guimarães,Andrea, AU - Paula,Carmen A, AU - Rezende,Simone A, AU - Saúde-Guimarães,Dênia A, Y1 - 2012/05/23/ PY - 2012/03/04/received PY - 2012/04/16/revised PY - 2012/04/22/accepted PY - 2012/5/24/entrez PY - 2012/5/24/pubmed PY - 2013/6/29/medline SP - 384 EP - 9 JF - Phytotherapy research : PTR JO - Phytother Res VL - 27 IS - 3 N2 - The aerial parts of Lychnophora trichocarpha Spreng. (Asteraceae) are used macerated in water or ethanol to treat inflammation, pain, rheumatism, contusions, bruises and insect bites in Brazilian traditional medicine. In this study, anti-inflammatory activity of ethanol extract from aerial parts of L. trichocarpha and its ethyl acetate fraction was investigated. Sesquiterpene lactones, lychnopholide (Lyc) and eremantholide C (EreC), isolated of ethyl acetate fraction, were also assayed for in vitro and in vivo anti-inflammatory activity. Topical treatment with ointments containing ethanol extract, its ethyl acetate fraction and sesquiterpene lactones significantly reduced carrageenan-induced mice paw oedema. In vitro assays demonstrated that Lyc inhibited interferon -γ/lipopolysaccharide -stimulated nitric oxide (NO) production in J774A.1 macrophages and increased production of IL-10 anti-inflammatory cytokine. The reduction of tumor necrosis factor-α (TNF-α) production by EreC was accompanied by an increased production of IL-10 in a concentration-dependent manner in J774A.1 macrophages. The anti-inflammatory effect of Lyc seems to involve the inhibition of production of NO and increased production of IL-10. The mechanism of the effect of EreC on the reduction of carrageenan-induced paw oedema may be attributed to inhibition of production of TNF-α and stimulation of IL-10 production. The results corroborate the use of ethanol extract from Lychnophora trichocarpha in folk medicine for anti-inflammatory action and indicate that the topical route is suitable for use. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22619042/Anti_inflammatory_sesquiterpene_lactones_from_Lychnophora_trichocarpha_Spreng___Brazilian_Arnica__ L2 - https://doi.org/10.1002/ptr.4736 DB - PRIME DP - Unbound Medicine ER -