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Role of vitamin d in Parkinson's disease.
ISRN Neurol 2012; 2012:134289IN

Abstract

Parkinson's disease (PD) is the second most common form of neurodegeneration in the elderly population. Clinically, it is characterized by tremor, rigidity, slowness of movement, and postural imbalance. A significant association between low serum vitamin D and PD has been demonstrated, suggesting that elevated vitamin D levels might provide protection against PD. Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene (PARP-1), neurotrophic factor (NTF), and Sp1 transcription factor. Vitamin D has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), nerve growth factor (NGF), matrix metalloproteinases (MMPs), prostaglandins (PGs) and cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS). A growing body of evidence suggests that vitamin D supplementation may be beneficial for PD patients. Among the different forms of vitamin D, calcitriol (1,25-dihydroxyvitamin D(3)) is best indicated for PD, because it is a highly active vitamin D(3) metabolite with an appropriate receptor in the central nervous system (CNS).

Authors+Show Affiliations

Vietnamese American Medical Research Foundation, Westminster, CA 92683, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22619734

Citation

L Ng, Khanh, and Lan Nguyễn. "Role of Vitamin D in Parkinson's Disease." ISRN Neurology, vol. 2012, 2012, p. 134289.
L Ng K, Nguyễn L. Role of vitamin d in Parkinson's disease. ISRN Neurol. 2012;2012:134289.
L Ng, K., & Nguyễn, L. (2012). Role of vitamin d in Parkinson's disease. ISRN Neurology, 2012, p. 134289. doi:10.5402/2012/134289.
L Ng K, Nguyễn L. Role of Vitamin D in Parkinson's Disease. ISRN Neurol. 2012;2012:134289. PubMed PMID: 22619734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of vitamin d in Parkinson's disease. AU - L Ng,Khanh, AU - Nguyễn,Lan, Y1 - 2012/03/07/ PY - 2011/10/18/received PY - 2011/11/29/accepted PY - 2012/5/24/entrez PY - 2012/5/24/pubmed PY - 2012/5/24/medline SP - 134289 EP - 134289 JF - ISRN neurology JO - ISRN Neurol VL - 2012 N2 - Parkinson's disease (PD) is the second most common form of neurodegeneration in the elderly population. Clinically, it is characterized by tremor, rigidity, slowness of movement, and postural imbalance. A significant association between low serum vitamin D and PD has been demonstrated, suggesting that elevated vitamin D levels might provide protection against PD. Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene (PARP-1), neurotrophic factor (NTF), and Sp1 transcription factor. Vitamin D has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), nerve growth factor (NGF), matrix metalloproteinases (MMPs), prostaglandins (PGs) and cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS). A growing body of evidence suggests that vitamin D supplementation may be beneficial for PD patients. Among the different forms of vitamin D, calcitriol (1,25-dihydroxyvitamin D(3)) is best indicated for PD, because it is a highly active vitamin D(3) metabolite with an appropriate receptor in the central nervous system (CNS). SN - 2090-5513 UR - https://www.unboundmedicine.com/medline/citation/22619734/Role_of_vitamin_d_in_Parkinson's_disease_ L2 - https://dx.doi.org/10.5402/2012/134289 DB - PRIME DP - Unbound Medicine ER -