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HLA B27 subtype distribution among patients with ankylosing spondylitis in eastern Turkey.
Genet Test Mol Biomarkers. 2012 May; 16(5):456-8.GT

Abstract

Human leukocyte antigen (HLA) B27 has a strong association with ankylosing spondylitis (AS) and other spondyloarthropathies. More than 70 subtypes of HLA B27 have been described. The present study investigated B27 subtype distribution among B27-positive patients with AS classified according to the modified New York criteria and healthy controls. Sequence-specific primer polymerase chain reaction technique was used for B27 subtyping of 43 unrelated patients with AS and 39 volunteer bone marrow donors. Among patients with AS, the male-female ratio was 6.2 and the mean age was 30 years. No relationship was found between the B27 subtypes and clinical and laboratory findings in patients with AS (p>0.05). Similarly, the frequencies of B27 subtypes did not significantly differ between patients and controls. In this study, B*2746, B*2749, and B*2767 subtypes were detected for the first time. Among B27 subtypes, the most common B27 alleles found in the patients and the controls were B*2702 and B*2705. In addition, B*2702 subtype was found predominantly in both patients (48.8%) and controls (46.2%). In conclusion, in addition to commonly encountered B*2702 and B*2705 HLA subtypes, a B*2749 subtype in a patient with AS and B*2746 as well as B*2767 subtypes in controls were determined for the first time.

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Authors+Show Affiliations

Diyarbakir E
Faculty of Medicine, Department of Medical Biology, Ataturk University, Erzurum, Turkey.
Eyerci N
No affiliation info available
Melikoglu M
No affiliation info available
Topcu A
No affiliation info available
Pirim I
No affiliation info available

MeSH

AdultCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseHLA-B27 AntigenHumansMalePolymerase Chain ReactionSpondylitis, AnkylosingTurkeyYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22621386

Citation

Diyarbakir, Eda, et al. "HLA B27 Subtype Distribution Among Patients With Ankylosing Spondylitis in Eastern Turkey." Genetic Testing and Molecular Biomarkers, vol. 16, no. 5, 2012, pp. 456-8.
Diyarbakir E, Eyerci N, Melikoglu M, et al. HLA B27 subtype distribution among patients with ankylosing spondylitis in eastern Turkey. Genet Test Mol Biomarkers. 2012;16(5):456-8.
Diyarbakir, E., Eyerci, N., Melikoglu, M., Topcu, A., & Pirim, I. (2012). HLA B27 subtype distribution among patients with ankylosing spondylitis in eastern Turkey. Genetic Testing and Molecular Biomarkers, 16(5), 456-8. https://doi.org/10.1089/gtmb.2011.0183
Diyarbakir E, et al. HLA B27 Subtype Distribution Among Patients With Ankylosing Spondylitis in Eastern Turkey. Genet Test Mol Biomarkers. 2012;16(5):456-8. PubMed PMID: 22621386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA B27 subtype distribution among patients with ankylosing spondylitis in eastern Turkey. AU - Diyarbakir,Eda, AU - Eyerci,Nilnur, AU - Melikoglu,Meltem, AU - Topcu,Atilla, AU - Pirim,Ibrahim, Y1 - 2012/03/21/ PY - 2012/5/25/entrez PY - 2012/5/25/pubmed PY - 2012/10/12/medline SP - 456 EP - 8 JF - Genetic testing and molecular biomarkers JO - Genet Test Mol Biomarkers VL - 16 IS - 5 N2 - Human leukocyte antigen (HLA) B27 has a strong association with ankylosing spondylitis (AS) and other spondyloarthropathies. More than 70 subtypes of HLA B27 have been described. The present study investigated B27 subtype distribution among B27-positive patients with AS classified according to the modified New York criteria and healthy controls. Sequence-specific primer polymerase chain reaction technique was used for B27 subtyping of 43 unrelated patients with AS and 39 volunteer bone marrow donors. Among patients with AS, the male-female ratio was 6.2 and the mean age was 30 years. No relationship was found between the B27 subtypes and clinical and laboratory findings in patients with AS (p>0.05). Similarly, the frequencies of B27 subtypes did not significantly differ between patients and controls. In this study, B*2746, B*2749, and B*2767 subtypes were detected for the first time. Among B27 subtypes, the most common B27 alleles found in the patients and the controls were B*2702 and B*2705. In addition, B*2702 subtype was found predominantly in both patients (48.8%) and controls (46.2%). In conclusion, in addition to commonly encountered B*2702 and B*2705 HLA subtypes, a B*2749 subtype in a patient with AS and B*2746 as well as B*2767 subtypes in controls were determined for the first time. SN - 1945-0257 UR - https://www.unboundmedicine.com/medline/citation/22621386/HLA_B27_subtype_distribution_among_patients_with_ankylosing_spondylitis_in_eastern_Turkey_ L2 - https://www.liebertpub.com/doi/10.1089/gtmb.2011.0183?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -