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Low-grade inflammation in young adults exposed to intrauterine hyperglycemia.
Diabetes Res Clin Pract 2012; 97(2):322-30DR

Abstract

AIM

To investigate associations between fetal exposure to intrauterine hyperglycemia and plasma concentrations of interleukin-6 (IL-6) and high sensitivity C-reactive protein (hs-CRP) in adult offspring.

METHOD

We studied 597 offspring, aged 18-27 years, from four different groups concerning exposure to intrauterine hyperglycemia and genetic predisposition to type 2 diabetes (offspring of women with: gestational diabetes mellitus (GDM), risk factors for GDM but normal glucose tolerance, type 1 diabetes and women from the background population, respectively). The participants were characterized by fasting plasma levels of IL-6 and hs-CRP, a 75 g oral glucose tolerance test and anthropometric measurements.

RESULTS

No association between intrauterine exposure to hyperglycemia and levels of IL-6 and hs-CRP in the offspring was found. In contrast maternal overweight (body mass index ≥ 25 kg/m(2)) was positively associated with levels of both IL-6 and hs-CRP (p for both=0.003). Offspring who had already developed overweight or conditions of abnormal glucose tolerance were characterized by higher levels of IL-6 and hs-CRP compared with the remaining offspring (all p<0.007).

CONCLUSION

Maternal overweight but not exposure to intrauterine hyperglycemia was associated with low-grade inflammation in adult offspring.

Authors+Show Affiliations

Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. louisekelstrup@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22622155

Citation

Kelstrup, Louise, et al. "Low-grade Inflammation in Young Adults Exposed to Intrauterine Hyperglycemia." Diabetes Research and Clinical Practice, vol. 97, no. 2, 2012, pp. 322-30.
Kelstrup L, Clausen TD, Mathiesen ER, et al. Low-grade inflammation in young adults exposed to intrauterine hyperglycemia. Diabetes Res Clin Pract. 2012;97(2):322-30.
Kelstrup, L., Clausen, T. D., Mathiesen, E. R., Hansen, T., & Damm, P. (2012). Low-grade inflammation in young adults exposed to intrauterine hyperglycemia. Diabetes Research and Clinical Practice, 97(2), pp. 322-30. doi:10.1016/j.diabres.2012.04.023.
Kelstrup L, et al. Low-grade Inflammation in Young Adults Exposed to Intrauterine Hyperglycemia. Diabetes Res Clin Pract. 2012;97(2):322-30. PubMed PMID: 22622155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-grade inflammation in young adults exposed to intrauterine hyperglycemia. AU - Kelstrup,Louise, AU - Clausen,Tine Dalsgaard, AU - Mathiesen,Elisabeth R, AU - Hansen,Torben, AU - Damm,Peter, Y1 - 2012/05/21/ PY - 2011/08/15/received PY - 2011/11/07/revised PY - 2012/04/26/accepted PY - 2012/5/25/entrez PY - 2012/5/25/pubmed PY - 2012/12/19/medline SP - 322 EP - 30 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 97 IS - 2 N2 - AIM: To investigate associations between fetal exposure to intrauterine hyperglycemia and plasma concentrations of interleukin-6 (IL-6) and high sensitivity C-reactive protein (hs-CRP) in adult offspring. METHOD: We studied 597 offspring, aged 18-27 years, from four different groups concerning exposure to intrauterine hyperglycemia and genetic predisposition to type 2 diabetes (offspring of women with: gestational diabetes mellitus (GDM), risk factors for GDM but normal glucose tolerance, type 1 diabetes and women from the background population, respectively). The participants were characterized by fasting plasma levels of IL-6 and hs-CRP, a 75 g oral glucose tolerance test and anthropometric measurements. RESULTS: No association between intrauterine exposure to hyperglycemia and levels of IL-6 and hs-CRP in the offspring was found. In contrast maternal overweight (body mass index ≥ 25 kg/m(2)) was positively associated with levels of both IL-6 and hs-CRP (p for both=0.003). Offspring who had already developed overweight or conditions of abnormal glucose tolerance were characterized by higher levels of IL-6 and hs-CRP compared with the remaining offspring (all p<0.007). CONCLUSION: Maternal overweight but not exposure to intrauterine hyperglycemia was associated with low-grade inflammation in adult offspring. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/22622155/Low_grade_inflammation_in_young_adults_exposed_to_intrauterine_hyperglycemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(12)00157-X DB - PRIME DP - Unbound Medicine ER -