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[Catatonia and neuroleptic malignant syndrome: two disorders on a same spectrum? Three case reports].
Riv Psichiatr. 2012 Mar-Apr; 47(2):178-85.RP

Abstract

AIM

The authors present the cases of three bipolar patients who developed Neuroleptic Malignant Syndrome (NMS) after antipsychotic treatment, both typical and atypical, focusing on relationship between NMS and catatonia.

METHODS

In all three cases, administration of antipsychotics has been stopped at once, when fever and autonomic disturbances occurred. A supportive therapy (including rehydration, electrolyte restoration and blood pressure aids, together with antipyretics, antibiotics and anticoagulants) was prescribed in order to stabilize general conditions. Every patient started then Electroconvulsive Therapy (ECT) in combination with benzodiazepines.

RESULTS

High risk of complications and lethal outcome, associated with NMS, were successfully reduced by the tempestive adoption of a supportive care, while combination between ECT and BDZ was effective in resolution of clinical picture. DISCUSSIONS; These cases may provide further evidences about hypothesis of catatonia and NMS as disorders on the same spectrum. In one patient, NMS occurred overlapping with a previous catatonic state, while two others exhibited catatonic features after resolution of NMS. However, catatonic symptoms arose or worsened with administration of antipsychotics, supporting hypothesis of neuroleptic-induced catatonia as a step of progressive development of NMS. Our experience also confirms efficacy and safety of ECT in combination with BDZ as treatment of NMS and residual catatonia.

Authors+Show Affiliations

Dipartimento di Psichiatria, Azienda Ospedaliero-Universitaria Pisana.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ita

PubMed ID

22622253

Citation

Luchini, Federica, et al. "[Catatonia and Neuroleptic Malignant Syndrome: Two Disorders On a Same Spectrum? Three Case Reports]." Rivista Di Psichiatria, vol. 47, no. 2, 2012, pp. 178-85.
Luchini F, Lattanzi L, Bartolommei N, et al. [Catatonia and neuroleptic malignant syndrome: two disorders on a same spectrum? Three case reports]. Riv Psichiatr. 2012;47(2):178-85.
Luchini, F., Lattanzi, L., Bartolommei, N., Cosentino, L., Casamassima, F., Litta, A., Mauri, M., & Cassano, G. B. (2012). [Catatonia and neuroleptic malignant syndrome: two disorders on a same spectrum? Three case reports]. Rivista Di Psichiatria, 47(2), 178-85. https://doi.org/10.1708/1069.11721
Luchini F, et al. [Catatonia and Neuroleptic Malignant Syndrome: Two Disorders On a Same Spectrum? Three Case Reports]. Riv Psichiatr. 2012 Mar-Apr;47(2):178-85. PubMed PMID: 22622253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Catatonia and neuroleptic malignant syndrome: two disorders on a same spectrum? Three case reports]. AU - Luchini,Federica, AU - Lattanzi,Lorenzo, AU - Bartolommei,Natalia, AU - Cosentino,Luca, AU - Casamassima,Francesco, AU - Litta,Antonella, AU - Mauri,Mauro, AU - Cassano,Giovanni Battista, PY - 2012/5/25/entrez PY - 2012/5/25/pubmed PY - 2012/11/1/medline SP - 178 EP - 85 JF - Rivista di psichiatria JO - Riv Psichiatr VL - 47 IS - 2 N2 - AIM: The authors present the cases of three bipolar patients who developed Neuroleptic Malignant Syndrome (NMS) after antipsychotic treatment, both typical and atypical, focusing on relationship between NMS and catatonia. METHODS: In all three cases, administration of antipsychotics has been stopped at once, when fever and autonomic disturbances occurred. A supportive therapy (including rehydration, electrolyte restoration and blood pressure aids, together with antipyretics, antibiotics and anticoagulants) was prescribed in order to stabilize general conditions. Every patient started then Electroconvulsive Therapy (ECT) in combination with benzodiazepines. RESULTS: High risk of complications and lethal outcome, associated with NMS, were successfully reduced by the tempestive adoption of a supportive care, while combination between ECT and BDZ was effective in resolution of clinical picture. DISCUSSIONS; These cases may provide further evidences about hypothesis of catatonia and NMS as disorders on the same spectrum. In one patient, NMS occurred overlapping with a previous catatonic state, while two others exhibited catatonic features after resolution of NMS. However, catatonic symptoms arose or worsened with administration of antipsychotics, supporting hypothesis of neuroleptic-induced catatonia as a step of progressive development of NMS. Our experience also confirms efficacy and safety of ECT in combination with BDZ as treatment of NMS and residual catatonia. SN - 0035-6484 UR - https://www.unboundmedicine.com/medline/citation/22622253/[Catatonia_and_neuroleptic_malignant_syndrome:_two_disorders_on_a_same_spectrum_Three_case_reports]_ L2 - https://doi.org/10.1708/1069.11721 DB - PRIME DP - Unbound Medicine ER -