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Pre-diagnostic alcohol consumption and breast cancer recurrence and mortality: results from a prospective cohort with a wide range of variation in alcohol intake.
Int J Cancer 2013; 132(3):686-94IJ

Abstract

The association between pre-diagnostic alcohol consumption and breast cancer recurrence and breast cancer specific mortality was investigated in 1,052 women diagnosed with early breast cancer in a prospective cohort of 29,875 women. Known clinical, lifestyle and socioeconomic risk factors were evaluated and adjusted for in multivariate analysis. We found a modest but significant association between pre-diagnostic alcohol consumption and breast cancer recurrence with a median follow-up of six years after date of diagnosis, both when using baseline measures of alcohol intake (HR, 1.65; 95% CI, 1.02-2.67; >2 units/day vs. ≤1 unit/day) and cumulated alcohol intake (HR, 2.02; 95% CI, 1.06-3.85; >40 drinking years vs. 0<drinking years≤10). Results for breast cancer specific mortality were also suggestive of a higher risk but were not statistically significant. In addition to being a risk factor for breast cancer, a high pre-diagnostic alcohol intake also seems to have an effect on the course of the disease. We could not relate the finding to a specific tumor presentation.

Authors+Show Affiliations

Unit of Diet, Genes, and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. marhol@cancer.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22623182

Citation

Holm, Marianne, et al. "Pre-diagnostic Alcohol Consumption and Breast Cancer Recurrence and Mortality: Results From a Prospective Cohort With a Wide Range of Variation in Alcohol Intake." International Journal of Cancer, vol. 132, no. 3, 2013, pp. 686-94.
Holm M, Olsen A, Christensen J, et al. Pre-diagnostic alcohol consumption and breast cancer recurrence and mortality: results from a prospective cohort with a wide range of variation in alcohol intake. Int J Cancer. 2013;132(3):686-94.
Holm, M., Olsen, A., Christensen, J., Kroman, N. T., Bidstrup, P. E., Johansen, C., ... Tjønneland, A. (2013). Pre-diagnostic alcohol consumption and breast cancer recurrence and mortality: results from a prospective cohort with a wide range of variation in alcohol intake. International Journal of Cancer, 132(3), pp. 686-94. doi:10.1002/ijc.27652.
Holm M, et al. Pre-diagnostic Alcohol Consumption and Breast Cancer Recurrence and Mortality: Results From a Prospective Cohort With a Wide Range of Variation in Alcohol Intake. Int J Cancer. 2013 Feb 1;132(3):686-94. PubMed PMID: 22623182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-diagnostic alcohol consumption and breast cancer recurrence and mortality: results from a prospective cohort with a wide range of variation in alcohol intake. AU - Holm,Marianne, AU - Olsen,Anja, AU - Christensen,Jane, AU - Kroman,Niels T, AU - Bidstrup,Pernille E, AU - Johansen,Christoffer, AU - Overvad,Kim, AU - Tjønneland,Anne, Y1 - 2012/06/20/ PY - 2011/12/19/received PY - 2012/05/10/accepted PY - 2012/5/25/entrez PY - 2012/5/25/pubmed PY - 2013/1/30/medline SP - 686 EP - 94 JF - International journal of cancer JO - Int. J. Cancer VL - 132 IS - 3 N2 - The association between pre-diagnostic alcohol consumption and breast cancer recurrence and breast cancer specific mortality was investigated in 1,052 women diagnosed with early breast cancer in a prospective cohort of 29,875 women. Known clinical, lifestyle and socioeconomic risk factors were evaluated and adjusted for in multivariate analysis. We found a modest but significant association between pre-diagnostic alcohol consumption and breast cancer recurrence with a median follow-up of six years after date of diagnosis, both when using baseline measures of alcohol intake (HR, 1.65; 95% CI, 1.02-2.67; >2 units/day vs. ≤1 unit/day) and cumulated alcohol intake (HR, 2.02; 95% CI, 1.06-3.85; >40 drinking years vs. 0<drinking years≤10). Results for breast cancer specific mortality were also suggestive of a higher risk but were not statistically significant. In addition to being a risk factor for breast cancer, a high pre-diagnostic alcohol intake also seems to have an effect on the course of the disease. We could not relate the finding to a specific tumor presentation. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22623182/Pre_diagnostic_alcohol_consumption_and_breast_cancer_recurrence_and_mortality:_results_from_a_prospective_cohort_with_a_wide_range_of_variation_in_alcohol_intake_ L2 - https://doi.org/10.1002/ijc.27652 DB - PRIME DP - Unbound Medicine ER -