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α-Lactalbumin and casein-glycomacropeptide do not affect iron absorption from formula in healthy term infants.
J Nutr. 2012 Jul; 142(7):1226-31.JN

Abstract

Iron absorption from infant formula is relatively low. α-Lactalbumin and casein-glycomacropeptide have been suggested to enhance mineral absorption. We therefore assessed the effect of α-lactalbumin and casein-glycomacropeptide on iron absorption from infant formula in healthy term infants. Thirty-one infants were randomly assigned to receive 1 of 3 formulas (4 mg iron/L, 13.1 g protein/L) from 4-8 wk to 6 mo of age: commercially available whey-predominant standard infant formula (standard formula), α-lactalbumin-enriched infant formula (α-LAC), or α-lactalbumin-enriched/casein-glycomacropeptide-reduced infant formula (α-LAC/RGMP). Nine breast-fed infants served as a reference. At 5.5 mo of age, (58)Fe was administered to all infants in a meal. Blood samples were collected 14 d later for iron absorption and iron status indices. Iron deficiency was defined as depleted iron stores, iron-deficient erythropoiesis, or iron deficiency anemia. Iron absorption (mean ± SD) was 10.3 ± 7.0% from standard formula, 8.6 ± 3.8% from α-LAC, 9.2 ± 6.5% from α-LAC/RGMP, and 12.9 ± 6.5% from breast milk, with no difference between the formula groups (P = 0.79) or all groups (P = 0.44). In the formula-fed infants only, iron absorption was negatively correlated with serum ferritin (r = -0.49; P = 0.005) and was higher (P = 0.023) in iron-deficient infants (16.4 ± 12.4%) compared with those with adequate iron status (8.6 ± 4.4%). Our findings indicate that α-lactalbumin and casein-glycomacropeptide do not affect iron absorption from infant formula in infants. Low serum ferritin concentrations are correlated with increased iron absorption from infant formula.

Authors+Show Affiliations

Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia. ewa.szymlekgay@deakin.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22623383

Citation

Szymlek-Gay, Ewa A., et al. "Α-Lactalbumin and Casein-glycomacropeptide Do Not Affect Iron Absorption From Formula in Healthy Term Infants." The Journal of Nutrition, vol. 142, no. 7, 2012, pp. 1226-31.
Szymlek-Gay EA, Lönnerdal B, Abrams SA, et al. Α-Lactalbumin and casein-glycomacropeptide do not affect iron absorption from formula in healthy term infants. J Nutr. 2012;142(7):1226-31.
Szymlek-Gay, E. A., Lönnerdal, B., Abrams, S. A., Kvistgaard, A. S., Domellöf, M., & Hernell, O. (2012). Α-Lactalbumin and casein-glycomacropeptide do not affect iron absorption from formula in healthy term infants. The Journal of Nutrition, 142(7), 1226-31. https://doi.org/10.3945/jn.111.153890
Szymlek-Gay EA, et al. Α-Lactalbumin and Casein-glycomacropeptide Do Not Affect Iron Absorption From Formula in Healthy Term Infants. J Nutr. 2012;142(7):1226-31. PubMed PMID: 22623383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - α-Lactalbumin and casein-glycomacropeptide do not affect iron absorption from formula in healthy term infants. AU - Szymlek-Gay,Ewa A, AU - Lönnerdal,Bo, AU - Abrams,Steven A, AU - Kvistgaard,Anne S, AU - Domellöf,Magnus, AU - Hernell,Olle, Y1 - 2012/05/23/ PY - 2012/5/25/entrez PY - 2012/5/25/pubmed PY - 2012/8/31/medline SP - 1226 EP - 31 JF - The Journal of nutrition JO - J Nutr VL - 142 IS - 7 N2 - Iron absorption from infant formula is relatively low. α-Lactalbumin and casein-glycomacropeptide have been suggested to enhance mineral absorption. We therefore assessed the effect of α-lactalbumin and casein-glycomacropeptide on iron absorption from infant formula in healthy term infants. Thirty-one infants were randomly assigned to receive 1 of 3 formulas (4 mg iron/L, 13.1 g protein/L) from 4-8 wk to 6 mo of age: commercially available whey-predominant standard infant formula (standard formula), α-lactalbumin-enriched infant formula (α-LAC), or α-lactalbumin-enriched/casein-glycomacropeptide-reduced infant formula (α-LAC/RGMP). Nine breast-fed infants served as a reference. At 5.5 mo of age, (58)Fe was administered to all infants in a meal. Blood samples were collected 14 d later for iron absorption and iron status indices. Iron deficiency was defined as depleted iron stores, iron-deficient erythropoiesis, or iron deficiency anemia. Iron absorption (mean ± SD) was 10.3 ± 7.0% from standard formula, 8.6 ± 3.8% from α-LAC, 9.2 ± 6.5% from α-LAC/RGMP, and 12.9 ± 6.5% from breast milk, with no difference between the formula groups (P = 0.79) or all groups (P = 0.44). In the formula-fed infants only, iron absorption was negatively correlated with serum ferritin (r = -0.49; P = 0.005) and was higher (P = 0.023) in iron-deficient infants (16.4 ± 12.4%) compared with those with adequate iron status (8.6 ± 4.4%). Our findings indicate that α-lactalbumin and casein-glycomacropeptide do not affect iron absorption from infant formula in infants. Low serum ferritin concentrations are correlated with increased iron absorption from infant formula. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22623383/α_Lactalbumin_and_casein_glycomacropeptide_do_not_affect_iron_absorption_from_formula_in_healthy_term_infants_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.111.153890 DB - PRIME DP - Unbound Medicine ER -