Tags

Type your tag names separated by a space and hit enter

Ergocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults.
J Nutr. 2012 Jul; 142(7):1246-52.JN

Abstract

Few foods contain ergocalciferol or cholecalciferol. Treatment of mushrooms with UV light increases ergocalciferol content and could provide a dietary source of vitamin D. We evaluated the impact of consuming UV-treated white button mushrooms (Agaricus bisporus) on the vitamin D status of healthy adults. Thirty-eight volunteers were randomized to 4 treatments consumed with a standard meal for 6 wk: the control (C) group received untreated mushrooms providing 0.85 μg/d ergocalciferol (n = 10); groups M1 and M2 received UV-treated mushrooms providing 8.8 (n = 10) and 17.1 μg/d (n = 9), respectively; and the supplement (S) group received purified ergocalciferol plus untreated mushrooms, providing a total of 28.2 μg/d (n = 9). Serum total 25-hydroxyvitamin D [25(OH)D] and 25-hydroxyergocalciferol [25(OH)D2] were 83 ± 38 and 2.4 ± 2.0 nmol/L, respectively, at baseline (mean ± SD). At wk 6, 25(OH)D2 had increased and was higher in all treatment groups than in the C group, whereas 25-hydroxycholecalciferol [25(OH)D3] had decreased and was lower in the M2 and S groups than in the C group. Increases in 25(OH)D2 for groups C, M1, M2, and S were 1.2 ± 5.2, 13.8 ± 7.3, 12.7 ± 3.7, and 32.8 ± 3.3 nmol/L and decreases in 25(OH)D3 were -3.9 ± 16.3, -10.4 ± 6.4, -20.6 ± 14.6, and -29.5 ± 15.9 nmol/L, respectively. Concentrations did not change in group C. In summary, ergocalciferol was absorbed and metabolized to 25(OH)D2 but did not affect vitamin D status, because 25(OH)D3 decreased proportionally.

Authors+Show Affiliations

USDA-Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, CA, USA. charles.stephensen@ars.usda.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22623385

Citation

Stephensen, Charles B., et al. "Ergocalciferol From Mushrooms or Supplements Consumed With a Standard Meal Increases 25-hydroxyergocalciferol but Decreases 25-hydroxycholecalciferol in the Serum of Healthy Adults." The Journal of Nutrition, vol. 142, no. 7, 2012, pp. 1246-52.
Stephensen CB, Zerofsky M, Burnett DJ, et al. Ergocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults. J Nutr. 2012;142(7):1246-52.
Stephensen, C. B., Zerofsky, M., Burnett, D. J., Lin, Y. P., Hammock, B. D., Hall, L. M., & McHugh, T. (2012). Ergocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults. The Journal of Nutrition, 142(7), 1246-52. https://doi.org/10.3945/jn.112.159764
Stephensen CB, et al. Ergocalciferol From Mushrooms or Supplements Consumed With a Standard Meal Increases 25-hydroxyergocalciferol but Decreases 25-hydroxycholecalciferol in the Serum of Healthy Adults. J Nutr. 2012;142(7):1246-52. PubMed PMID: 22623385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ergocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults. AU - Stephensen,Charles B, AU - Zerofsky,Melissa, AU - Burnett,Dustin J, AU - Lin,Yan-Ping, AU - Hammock,Bruce D, AU - Hall,Laura M, AU - McHugh,Tara, Y1 - 2012/05/23/ PY - 2012/5/25/entrez PY - 2012/5/25/pubmed PY - 2012/8/31/medline SP - 1246 EP - 52 JF - The Journal of nutrition JO - J Nutr VL - 142 IS - 7 N2 - Few foods contain ergocalciferol or cholecalciferol. Treatment of mushrooms with UV light increases ergocalciferol content and could provide a dietary source of vitamin D. We evaluated the impact of consuming UV-treated white button mushrooms (Agaricus bisporus) on the vitamin D status of healthy adults. Thirty-eight volunteers were randomized to 4 treatments consumed with a standard meal for 6 wk: the control (C) group received untreated mushrooms providing 0.85 μg/d ergocalciferol (n = 10); groups M1 and M2 received UV-treated mushrooms providing 8.8 (n = 10) and 17.1 μg/d (n = 9), respectively; and the supplement (S) group received purified ergocalciferol plus untreated mushrooms, providing a total of 28.2 μg/d (n = 9). Serum total 25-hydroxyvitamin D [25(OH)D] and 25-hydroxyergocalciferol [25(OH)D2] were 83 ± 38 and 2.4 ± 2.0 nmol/L, respectively, at baseline (mean ± SD). At wk 6, 25(OH)D2 had increased and was higher in all treatment groups than in the C group, whereas 25-hydroxycholecalciferol [25(OH)D3] had decreased and was lower in the M2 and S groups than in the C group. Increases in 25(OH)D2 for groups C, M1, M2, and S were 1.2 ± 5.2, 13.8 ± 7.3, 12.7 ± 3.7, and 32.8 ± 3.3 nmol/L and decreases in 25(OH)D3 were -3.9 ± 16.3, -10.4 ± 6.4, -20.6 ± 14.6, and -29.5 ± 15.9 nmol/L, respectively. Concentrations did not change in group C. In summary, ergocalciferol was absorbed and metabolized to 25(OH)D2 but did not affect vitamin D status, because 25(OH)D3 decreased proportionally. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22623385/Ergocalciferol_from_mushrooms_or_supplements_consumed_with_a_standard_meal_increases_25_hydroxyergocalciferol_but_decreases_25_hydroxycholecalciferol_in_the_serum_of_healthy_adults_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.159764 DB - PRIME DP - Unbound Medicine ER -