Tags

Type your tag names separated by a space and hit enter

Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B.
J Nutr. 2012 Jul; 142(7):1286-90.JN

Abstract

Uncertainty remains regarding the efficacy of low intakes of ergocalciferol (vitamin D2 or D2) and cholecalciferol (vitamin D3 or D3) provided in food to increase serum 25-hydroxy-vitamin D (25-OH-D) metabolite concentrations when UV-B exposure is low. We recruited 40 healthy men and women into a double-blind, parallel design, randomized controlled trial. Participants received placebo or 1 of 4 experimental treatments (D2 or D3 at 5 or 10 μg/d) supplied as a malted milk drink for 4 wk during a period of minimal UV-B exposure in the UK. The primary outcome was a change in serum 25-OH-D2 and 25-OH-D3 concentrations measured by ultra-performance liquid chromatography tandem MS. The secondary outcomes were changes in concentrations of plasma parathyroid hormone and serum calcium (Ca(2+)). Baseline concentrations (geometric mean ± SD) of 25-OH-D2, 25-OH-D3, and total 25-OH-D were 3 ± 4, 32 ± 22, and 37 ± 22 nmol/L, respectively. Both D2- and D3-fortified drinks resulted in dose-dependent increases (P < 0.001) in their respective 25-OH metabolites that did not significantly differ in size. Increments from baseline compared with the placebo group following 5 and 10 μg/d of D2 were (mean ± SEM) 9.4 ± 2.5 and 17.8 ± 2.4 nmol/L for 25-OH-D2 and following 5 and 10 μg/d of D3 were 15.1 ± 4.7 and 22.9 ± 4.6 nmol/L for 25-OH-D3, respectively. There was no difference between D2 and D3 groups in the incremental AUC of their respective metabolites. These findings suggest that D2 and D3 are equipotent in increasing 25-OH-D in healthy men and women with negligible UV-B exposure.

Authors+Show Affiliations

Diabetes and Nutritional Sciences Division, School of Medicine, King's College, Waterloo Campus, London, UK. catherine.fisk@kcl.acNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22623396

Citation

Fisk, Catherine M., et al. "Fortified Malted Milk Drinks Containing Low-dose Ergocalciferol and Cholecalciferol Do Not Differ in Their Capacity to Raise Serum 25-hydroxyvitamin D Concentrations in Healthy Men and Women Not Exposed to UV-B." The Journal of Nutrition, vol. 142, no. 7, 2012, pp. 1286-90.
Fisk CM, Theobald HE, Sanders TA. Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B. J Nutr. 2012;142(7):1286-90.
Fisk, C. M., Theobald, H. E., & Sanders, T. A. (2012). Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B. The Journal of Nutrition, 142(7), 1286-90. https://doi.org/10.3945/jn.111.156166
Fisk CM, Theobald HE, Sanders TA. Fortified Malted Milk Drinks Containing Low-dose Ergocalciferol and Cholecalciferol Do Not Differ in Their Capacity to Raise Serum 25-hydroxyvitamin D Concentrations in Healthy Men and Women Not Exposed to UV-B. J Nutr. 2012;142(7):1286-90. PubMed PMID: 22623396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B. AU - Fisk,Catherine M, AU - Theobald,Hannah E, AU - Sanders,Thomas A B, Y1 - 2012/05/23/ PY - 2012/5/25/entrez PY - 2012/5/25/pubmed PY - 2012/8/31/medline SP - 1286 EP - 90 JF - The Journal of nutrition JO - J Nutr VL - 142 IS - 7 N2 - Uncertainty remains regarding the efficacy of low intakes of ergocalciferol (vitamin D2 or D2) and cholecalciferol (vitamin D3 or D3) provided in food to increase serum 25-hydroxy-vitamin D (25-OH-D) metabolite concentrations when UV-B exposure is low. We recruited 40 healthy men and women into a double-blind, parallel design, randomized controlled trial. Participants received placebo or 1 of 4 experimental treatments (D2 or D3 at 5 or 10 μg/d) supplied as a malted milk drink for 4 wk during a period of minimal UV-B exposure in the UK. The primary outcome was a change in serum 25-OH-D2 and 25-OH-D3 concentrations measured by ultra-performance liquid chromatography tandem MS. The secondary outcomes were changes in concentrations of plasma parathyroid hormone and serum calcium (Ca(2+)). Baseline concentrations (geometric mean ± SD) of 25-OH-D2, 25-OH-D3, and total 25-OH-D were 3 ± 4, 32 ± 22, and 37 ± 22 nmol/L, respectively. Both D2- and D3-fortified drinks resulted in dose-dependent increases (P < 0.001) in their respective 25-OH metabolites that did not significantly differ in size. Increments from baseline compared with the placebo group following 5 and 10 μg/d of D2 were (mean ± SEM) 9.4 ± 2.5 and 17.8 ± 2.4 nmol/L for 25-OH-D2 and following 5 and 10 μg/d of D3 were 15.1 ± 4.7 and 22.9 ± 4.6 nmol/L for 25-OH-D3, respectively. There was no difference between D2 and D3 groups in the incremental AUC of their respective metabolites. These findings suggest that D2 and D3 are equipotent in increasing 25-OH-D in healthy men and women with negligible UV-B exposure. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22623396/Fortified_malted_milk_drinks_containing_low_dose_ergocalciferol_and_cholecalciferol_do_not_differ_in_their_capacity_to_raise_serum_25_hydroxyvitamin_D_concentrations_in_healthy_men_and_women_not_exposed_to_UV_B_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.111.156166 DB - PRIME DP - Unbound Medicine ER -