Tags

Type your tag names separated by a space and hit enter

Frequency of low bone mineral density in Saudi patients with inflammatory bowel disease.
Saudi J Gastroenterol. 2012 May-Jun; 18(3):201-7.SJ

Abstract

BACKGROUND/AIMS

Metabolic bone disease is common in patients with inflammatory bowel disease (IBD). Our aim was to determine the frequency of bone loss among Saudi patients with IBD and possible contributing risk factors.

SETTINGS AND DESIGN

We retrospectively reviewed Saudi patients with IBD, between 18 and 70 years of age, who had bone mass density (BMD) determined by dual-energy X-ray absorptiometry scanning at one of three hospitals in the Kingdom of Saudi Arabia from 2001 to 2008.

PATIENTS AND METHODS

Case notes and BMDs results were carefully reviewed for demographic and clinical data. Low bone mass, osteopenia, and osteoporosis were defined according to the WHO guidelines.

STATISTICAL ANALYSIS USED

Predictive factors for BMD were analyzed using group comparisons and stepwise regression analyses.

RESULTS

Ninety-five patients were included; 46% had Crohn's disease (CD) and 54% had ulcerative colitis (UC). The average age was 30.9±11.6 years. Using T-scores, the frequency of osteopenia was 44.2%, and the frequency of osteoporosis was 30.5% at both lumbar spine and proximal femur. Only 25.3% of patients exhibited a BMD within the normal range. Our results revealed a positive correlation between the Z-score in both the lumbar spine and the proximal femur and body mass index (BMI) (P=0.042 and P=0.018, respectively). On regression analysis BMI, age, and calcium supplementation were found to be the most important independent predictors of BMD.

CONCLUSIONS

Saudi patients with IBD are at an increased risk of low BMD and the frequency of decreased BMD in Saudi patients with CD and UC were similar. BMI and age were the most important independent predictors of low BMD.

Authors+Show Affiliations

Division of Gastroenterology, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia. mismail.md@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22626800

Citation

Ismail, Mona H., et al. "Frequency of Low Bone Mineral Density in Saudi Patients With Inflammatory Bowel Disease." Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, vol. 18, no. 3, 2012, pp. 201-7.
Ismail MH, Al-Elq AH, Al-Jarodi ME, et al. Frequency of low bone mineral density in Saudi patients with inflammatory bowel disease. Saudi J Gastroenterol. 2012;18(3):201-7.
Ismail, M. H., Al-Elq, A. H., Al-Jarodi, M. E., Azzam, N. A., Aljebreen, A. M., Al-Momen, S. A., Bseiso, B. F., Al-Mulhim, F. A., & Alquorain, A. (2012). Frequency of low bone mineral density in Saudi patients with inflammatory bowel disease. Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 18(3), 201-7. https://doi.org/10.4103/1319-3767.96458
Ismail MH, et al. Frequency of Low Bone Mineral Density in Saudi Patients With Inflammatory Bowel Disease. Saudi J Gastroenterol. 2012 May-Jun;18(3):201-7. PubMed PMID: 22626800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of low bone mineral density in Saudi patients with inflammatory bowel disease. AU - Ismail,Mona H, AU - Al-Elq,Abdulmohsen H, AU - Al-Jarodi,Mahdi E, AU - Azzam,Nahla A, AU - Aljebreen,Abdulrahman M, AU - Al-Momen,Sami A, AU - Bseiso,Bahaa F, AU - Al-Mulhim,Fatma A, AU - Alquorain,Abdulaziz, PY - 2012/5/26/entrez PY - 2012/5/26/pubmed PY - 2012/10/25/medline SP - 201 EP - 7 JF - Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association JO - Saudi J Gastroenterol VL - 18 IS - 3 N2 - BACKGROUND/AIMS: Metabolic bone disease is common in patients with inflammatory bowel disease (IBD). Our aim was to determine the frequency of bone loss among Saudi patients with IBD and possible contributing risk factors. SETTINGS AND DESIGN: We retrospectively reviewed Saudi patients with IBD, between 18 and 70 years of age, who had bone mass density (BMD) determined by dual-energy X-ray absorptiometry scanning at one of three hospitals in the Kingdom of Saudi Arabia from 2001 to 2008. PATIENTS AND METHODS: Case notes and BMDs results were carefully reviewed for demographic and clinical data. Low bone mass, osteopenia, and osteoporosis were defined according to the WHO guidelines. STATISTICAL ANALYSIS USED: Predictive factors for BMD were analyzed using group comparisons and stepwise regression analyses. RESULTS: Ninety-five patients were included; 46% had Crohn's disease (CD) and 54% had ulcerative colitis (UC). The average age was 30.9±11.6 years. Using T-scores, the frequency of osteopenia was 44.2%, and the frequency of osteoporosis was 30.5% at both lumbar spine and proximal femur. Only 25.3% of patients exhibited a BMD within the normal range. Our results revealed a positive correlation between the Z-score in both the lumbar spine and the proximal femur and body mass index (BMI) (P=0.042 and P=0.018, respectively). On regression analysis BMI, age, and calcium supplementation were found to be the most important independent predictors of BMD. CONCLUSIONS: Saudi patients with IBD are at an increased risk of low BMD and the frequency of decreased BMD in Saudi patients with CD and UC were similar. BMI and age were the most important independent predictors of low BMD. SN - 1998-4049 UR - https://www.unboundmedicine.com/medline/citation/22626800/Frequency_of_low_bone_mineral_density_in_Saudi_patients_with_inflammatory_bowel_disease_ L2 - http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2012;volume=18;issue=3;spage=201;epage=207;aulast=Ismail DB - PRIME DP - Unbound Medicine ER -