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FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies.
PLoS One. 2012; 7(5):e37780.Plos

Abstract

BACKGROUND

Elevated cholesterol levels in children can be a risk factor for cardiovascular diseases in later life. In adults, it has been shown that blood lipid levels are strongly influenced by polymorphisms in the fatty acid desaturase (FADS) gene cluster in addition to nutritional and other exogenous and endogenous determinants. Our aim was to investigate whether lipid levels are determined by the FADS genotype already in children and whether this association interacts with dietary intake of n-3 fatty acids.

METHODS

The analysis was based on data of 2006 children from two German prospective birth cohort studies. Total cholesterol, HDL, LDL and triglycerides were measured at 10 years of age. Six single nucleotide polymorphisms (SNPs) of the FADS gene cluster were genotyped. Dietary n-3 fatty acid intake was assessed by food frequency questionnaire. Linear regression modeling was used to assess the association between lipid levels, n-3 fatty acid intake and FADS genotype.

RESULTS

Individuals carrying the homozygous minor allele had lower levels of total cholesterol [means ratio (MR) ranging from 0.96 (p = 0.0093) to 0.98 (p = 0.2949), depending on SNPs] and LDL [MR between 0.94 (p = 0.0179) and 0.97 (p = 0.2963)] compared to homozygous major allele carriers. Carriers of the heterozygous allele showed lower HDL levels [β between -0.04 (p = 0.0074) to -0.01 (p = 0.3318)] and higher triglyceride levels [MR ranging from 1.06 (p = 0.0065) to 1.07 (p = 0.0028)] compared to homozygous major allele carriers. A higher n-3 PUFA intake was associated with higher concentrations of total cholesterol, LDL, HDL and lower triglyceride levels, but these associations did not interact with the FADS1 FADS2 genotype.

CONCLUSION

Total cholesterol, HDL, LDL and triglyceride concentrations may be influenced by the FADS1 FADS2 genotype already in 10 year old children. Genetically determined blood lipid levels during childhood might differentially predispose individuals to the development of cardiovascular diseases later in life.

Authors+Show Affiliations

Institute of Epidemiology I, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22629455

Citation

Standl, Marie, et al. "FADS1 FADS2 Gene Cluster, PUFA Intake and Blood Lipids in Children: Results From the GINIplus and LISAplus Studies." PloS One, vol. 7, no. 5, 2012, pp. e37780.
Standl M, Lattka E, Stach B, et al. FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies. PLoS ONE. 2012;7(5):e37780.
Standl, M., Lattka, E., Stach, B., Koletzko, S., Bauer, C. P., von Berg, A., Berdel, D., Krämer, U., Schaaf, B., Röder, S., Herbarth, O., Buyken, A., Drogies, T., Thiery, J., Koletzko, B., & Heinrich, J. (2012). FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies. PloS One, 7(5), e37780. https://doi.org/10.1371/journal.pone.0037780
Standl M, et al. FADS1 FADS2 Gene Cluster, PUFA Intake and Blood Lipids in Children: Results From the GINIplus and LISAplus Studies. PLoS ONE. 2012;7(5):e37780. PubMed PMID: 22629455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies. AU - Standl,Marie, AU - Lattka,Eva, AU - Stach,Barbara, AU - Koletzko,Sibylle, AU - Bauer,Carl-Peter, AU - von Berg,Andrea, AU - Berdel,Dietrich, AU - Krämer,Ursula, AU - Schaaf,Beate, AU - Röder,Stefan, AU - Herbarth,Olf, AU - Buyken,Anette, AU - Drogies,Tim, AU - Thiery,Joachim, AU - Koletzko,Berthold, AU - Heinrich,Joachim, AU - ,, AU - ,, Y1 - 2012/05/21/ PY - 2011/11/17/received PY - 2012/04/27/accepted PY - 2012/5/26/entrez PY - 2012/5/26/pubmed PY - 2012/12/18/medline SP - e37780 EP - e37780 JF - PloS one JO - PLoS ONE VL - 7 IS - 5 N2 - BACKGROUND: Elevated cholesterol levels in children can be a risk factor for cardiovascular diseases in later life. In adults, it has been shown that blood lipid levels are strongly influenced by polymorphisms in the fatty acid desaturase (FADS) gene cluster in addition to nutritional and other exogenous and endogenous determinants. Our aim was to investigate whether lipid levels are determined by the FADS genotype already in children and whether this association interacts with dietary intake of n-3 fatty acids. METHODS: The analysis was based on data of 2006 children from two German prospective birth cohort studies. Total cholesterol, HDL, LDL and triglycerides were measured at 10 years of age. Six single nucleotide polymorphisms (SNPs) of the FADS gene cluster were genotyped. Dietary n-3 fatty acid intake was assessed by food frequency questionnaire. Linear regression modeling was used to assess the association between lipid levels, n-3 fatty acid intake and FADS genotype. RESULTS: Individuals carrying the homozygous minor allele had lower levels of total cholesterol [means ratio (MR) ranging from 0.96 (p = 0.0093) to 0.98 (p = 0.2949), depending on SNPs] and LDL [MR between 0.94 (p = 0.0179) and 0.97 (p = 0.2963)] compared to homozygous major allele carriers. Carriers of the heterozygous allele showed lower HDL levels [β between -0.04 (p = 0.0074) to -0.01 (p = 0.3318)] and higher triglyceride levels [MR ranging from 1.06 (p = 0.0065) to 1.07 (p = 0.0028)] compared to homozygous major allele carriers. A higher n-3 PUFA intake was associated with higher concentrations of total cholesterol, LDL, HDL and lower triglyceride levels, but these associations did not interact with the FADS1 FADS2 genotype. CONCLUSION: Total cholesterol, HDL, LDL and triglyceride concentrations may be influenced by the FADS1 FADS2 genotype already in 10 year old children. Genetically determined blood lipid levels during childhood might differentially predispose individuals to the development of cardiovascular diseases later in life. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22629455/FADS1_FADS2_gene_cluster_PUFA_intake_and_blood_lipids_in_children:_results_from_the_GINIplus_and_LISAplus_studies_ L2 - http://dx.plos.org/10.1371/journal.pone.0037780 DB - PRIME DP - Unbound Medicine ER -