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Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice.
CNS Neurosci Ther. 2012 Aug; 18(8):623-30.CN

Abstract

AIMS

Safranal (2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde, C(10) H(14) O) is an active ingredient in the saffron, which is used in traditional medicine. It has been reported to have sedative and anti-epileptic effects, but its hypnotic effects remain uncertain. The aim of this study was to evaluate effects of safranal on sleep-wake cycle.

METHODS

We established hypnotic-model mice treated with a low dose of pentobarbital 20 mg/kg, and administered different doses of safranal, vehicle, or diazepam. The change of sleep-wake cycle was assessed by sleep recording and c-Fos expression in the brain was analyzed by immunohistochemistry.

RESULTS

Safranal increased the duration of non-rapid eye movement (NREM) sleep, shortened NREM sleep latency, and enhanced the delta power activity of NREM sleep. Immunohistochemical evaluation revealed that safranal increased c-Fos expression in the ventrolateral preoptic nucleus (VLPO), one of the putative sleep centers, and decreased it in the arousal histaminergic tuberomammillary nuclei (TMN).

CONCLUSION

These findings indicate that safranal enhances NREM sleep in pentobarbital-treated mice. The hypnotic effects of safranal may be related to the activation of the sleep-promoting neurons in the VLPO and the simultaneous inhibition of the wakefulness-promoting neurons in the TMN, suggesting that safranal may be a hypnotic substance.

Authors+Show Affiliations

State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22632633

Citation

Liu, Zheng, et al. "Safranal Enhances Non-rapid Eye Movement Sleep in Pentobarbital-treated Mice." CNS Neuroscience & Therapeutics, vol. 18, no. 8, 2012, pp. 623-30.
Liu Z, Xu XH, Liu TY, et al. Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice. CNS Neurosci Ther. 2012;18(8):623-30.
Liu, Z., Xu, X. H., Liu, T. Y., Hong, Z. Y., Urade, Y., Huang, Z. L., & Qu, W. M. (2012). Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice. CNS Neuroscience & Therapeutics, 18(8), 623-30. https://doi.org/10.1111/j.1755-5949.2012.00334.x
Liu Z, et al. Safranal Enhances Non-rapid Eye Movement Sleep in Pentobarbital-treated Mice. CNS Neurosci Ther. 2012;18(8):623-30. PubMed PMID: 22632633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice. AU - Liu,Zheng, AU - Xu,Xin-Hong, AU - Liu,Tian-Ya, AU - Hong,Zong-Yuan, AU - Urade,Yoshihiro, AU - Huang,Zhi-Li, AU - Qu,Wei-Min, Y1 - 2012/05/28/ PY - 2012/5/29/entrez PY - 2012/5/29/pubmed PY - 2013/1/23/medline SP - 623 EP - 30 JF - CNS neuroscience & therapeutics JO - CNS Neurosci Ther VL - 18 IS - 8 N2 - AIMS: Safranal (2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde, C(10) H(14) O) is an active ingredient in the saffron, which is used in traditional medicine. It has been reported to have sedative and anti-epileptic effects, but its hypnotic effects remain uncertain. The aim of this study was to evaluate effects of safranal on sleep-wake cycle. METHODS: We established hypnotic-model mice treated with a low dose of pentobarbital 20 mg/kg, and administered different doses of safranal, vehicle, or diazepam. The change of sleep-wake cycle was assessed by sleep recording and c-Fos expression in the brain was analyzed by immunohistochemistry. RESULTS: Safranal increased the duration of non-rapid eye movement (NREM) sleep, shortened NREM sleep latency, and enhanced the delta power activity of NREM sleep. Immunohistochemical evaluation revealed that safranal increased c-Fos expression in the ventrolateral preoptic nucleus (VLPO), one of the putative sleep centers, and decreased it in the arousal histaminergic tuberomammillary nuclei (TMN). CONCLUSION: These findings indicate that safranal enhances NREM sleep in pentobarbital-treated mice. The hypnotic effects of safranal may be related to the activation of the sleep-promoting neurons in the VLPO and the simultaneous inhibition of the wakefulness-promoting neurons in the TMN, suggesting that safranal may be a hypnotic substance. SN - 1755-5949 UR - https://www.unboundmedicine.com/medline/citation/22632633/Safranal_enhances_non_rapid_eye_movement_sleep_in_pentobarbital_treated_mice_ L2 - https://doi.org/10.1111/j.1755-5949.2012.00334.x DB - PRIME DP - Unbound Medicine ER -